医院绩效管理研究与探索

At first, the article introduces the history and present status of performance management in hospitals. Second, it lays out the basic theories of performance management, from three aspects of the concept, process and method. Specially, in home and abroad, there are two performance management methods always to be used. They are Key Performance Indicator ( KPI) and Balance Scorecard (BSC). Performance management was a process of plan, action, communication, evaluation and feedback in hospital staff or section’s behavior and result. Good performance management system could promote staff capacity and improve total performance in organization. In the last part, performance management is important for hospital. It could improve efficiency and service quality, which is the effectiveness for hospital’s managing. It is necessary to maintain the core competency by the performance management system of hospital.首先，介绍医院绩效管理研究的历史背景和现状。其次，总结绩效管理的理论基础，从绩效管理的概念、过程、方法三个方面进行了说明。特别是绩效管理方法，目前国内外广泛被研究和应用的主要有两种，分别是关键业绩指标法和平衡计分法。绩效管理体系是绩效计划、绩效执行、绩效沟通、绩效评估和医院员工或者组织行为绩效结果反馈的过程。完善的绩效管理体系能够促进员工能力发展、改进组织整体的绩效。最后绩效管理对提高医院的工作效率和服务质量有着重要的作用，成为医院运营的有效措施。通过构建有效的绩效管理体系，可建立医院核心竞争力，保持医院长久可持续发展的竞争优势

Tetra­aqua­diazido­cobalt(II) 4,4′-dicarboxyl­ato-1,1′-ethyl­enedi­pyridinium dihydrate

In the title compound, [Co(N3)2(H2O)4]·C14H12N2O4·2H2O, the metal complex mol­ecule is centrosymmetric, the Co(II) ion being six-coordinated by two azide N atoms and four aqua O atoms with a trans-octa­hedral geometry. The zwitterionic organic mol­ecule is also centrosymmetric. In the crystal, the components are associated into a two-dimensional network through O—H⋯O hydrogen bonds. Further O—H⋯O and O—H⋯N inter­actions give a three-dimensional structure. The free water molecule is disordered over two positions in a 0.787 (5):0.213 (5) ratio

Non-intact zona improves development of murine preimplantation embryos transfected by an adenovirus vector

The present study explored whether embryos could be transfected by the adenovirus-vector if the zona pellucida (ZP) was not completely removed. An adenovirus vector with green fluorescent protein (pAd-GFP) was used to transfect mouse non-intact zona zygotes (following partial removal of the ZP induced by pronase), zona-free and zona-intact embryos. Non-intact zona and zona-free embryos expressed GFP (confirmed with inverted fluorescence microscopy) after 48 h of culture. The transfection rate of non-intact zona group was up to 51% and the entire zona-free group was transfected. However, none of the zona-intact embryos was transfected. Regardless of whether non-intact zona embryos were transfected by pAd-GFP, their developmental rate (74.3 ± 2.4 and 69.2 ± 3.3% for non-transfected and transfected, respectively; mean ± SEM) was higher (P<0.05) than that of zona-free embryos without and with transfection (54.5 ± 4.3 and 46.7 ± 5.5%). Developmental potential of embryos was decreased for ZP-digestion (non-intact zona 71.8 ± 1.6%; zona-free 50.6 ± 2.2%, P<0.05) or pAd-GFP expression (non-transfected 64.4 ± 1.9%; transfected 56.0 ± 2.1%, P<0.05); therefore, ZP-digestion affected more intensely embryos development than pAd-GFP expression. In summary, non-intact zona murine embryos were readily transfected by the adenovirus-vector, and had much greater development potential than zona-free embryos. Although, the susceptibility of the ZP to digestion by pronase varied among embryos, on average, approximately 3.5 to 4.0 min of digestion resulted in partial removal of the ZP and promoted both transfection and satisfactory embryonic development. It is expected that this method could be used to increase the efficiency of generating transgenic animals.Keywords: Mouse, non-intact zona embryos, adenovirus vector with green fluorescent protein (pAd-GFP), embryos developmen

Association between platelet distribution width and serum uric acid in Chinese population

© 2019 International Union of Biochemistry and Molecular Biology Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This cross-sectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P < 0.05). This study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males. © 2019 BioFactors, 45(3):326–334, 2019

Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction

© 2019 Jingkai Zhang et al. Objective. Both hypertension and subclinical thyroid dysfunction (STD) have high prevalence and clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between hypertension and STD in Chinese. Methods. We recruited 13,380 ostensible healthy participants (8,237 men and 5,143 women). The associations between hypertension and STD were analyzed on a gender-based setting after dividing STD into subclinical hypothyroidism, subclinical hyperthyroidism and further subgrouped euthyroidism. Crude and adjusted odds ratios of STD for hypertension were analyzed by binary logistic regression. Results. An increasing trend of hypertension prevalence was found along with aging in both genders. Yet, higher male hypertension prevalence was found until 65 years, and then it intersected with female hypertension prevalence. Women had significantly higher propensity for STD than men. Yet, in elderly participants, this gender-specific difference became less obvious. We displayed detrimental effects for subclinical hypothyroidism in both genders after multiple-covariate adjustments, yet no such effects were shown for subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism were more likely to be associated with hypertension than males, and the corresponding odds ratios were 1.619 (

Concept for a Future Super Proton-Proton Collider

Following the discovery of the Higgs boson at LHC, new large colliders are being studied by the international high-energy community to explore Higgs physics in detail and new physics beyond the Standard Model. In China, a two-stage circular collider project CEPC-SPPC is proposed, with the first stage CEPC (Circular Electron Positron Collier, a so-called Higgs factory) focused on Higgs physics, and the second stage SPPC (Super Proton-Proton Collider) focused on new physics beyond the Standard Model. This paper discusses this second stage.Comment: 34 pages, 8 figures, 5 table

Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)

Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.Improving the Ability of Diagnosis and Treatment of Difficult Disease