N-Phenyl­anthranilic anhydride

The complete mol­ecule of the title compound, C26H20N2O3, is generated by crystallographic twofold symmetry, with the central O atom lying on the rotation axis. The conformation is stabilized by an intra­molecular N—H⋯O hydrogen bond. The dihedral angle between the inner and outer aromatic ring planes is 61.12 (5)°

3-Ethyl 5-methyl 4-(2,3-dichloro­phen­yl)-2,6-dimethyl­pyridine-3,5-dicarboxyl­ate

In the title compound, C18H17Cl2NO4, an oxidation product of felodipine, the dihedral angle between the benzene and pyridine rings is 75.3 (4)°. The crystal structure is stabilized by intermolecular C—H⋯O interactions

An amine-reactive tetraphenylethylene derivative for protein detection in SDS-PAGE

A new aggregation-induced emission (AIE) compound 1,2-bis[4-(isothiocyanatomethyl)phenyl]-1,2-diphenylethene (2) was synthesized for use in SDS-PAGE. The molecule is practically nonemissive in solution but becomes highly emissive after reacting with the amine groups of the proteins by either the prestaining or poststaining method. The sensitivity of 2 achieved in the prestaining method is the same as that of Coomassie brilliant blue (CBB), while that observed in the poststaining method is higher than that of CBB. Excellent linear responses with the amount of protein were obtained in both cases. The detection of a mixture of proteins with different molecular weights was successfully achieved

1,4-Dibromo-2,5-dimeth­oxy­benzene

The asymmetric unit of the title compound, C8H8Br2O2, contains one half-mol­ecule, the complete mol­ecule being generated by inversion symmetry

Abietane Diterpenoids and a Lignan from Pinus yunnanensis

Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4 -11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1 -3 exhibited high inhibitions on Cox-2 (> 80 %) and low inhibitions on Cox-1 (< 50 %), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09 % and 61.30 %, respectively. Compounds 1 -11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control

Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer

Clinicopathologic factors and Gab2 expression in 35 CRC patients. (DOCX 22 kb