Re-conceptualization of the “Chinese Expert Guidelines for the Prevention of Stroke Associated with Patent Foramen Ovale” for the Management of Perioperative Stroke in Patients with Lung Cancer

The Chinese Heart Journal published the “Chinese Expert Guidelines for the Prevention of Stroke Associated with Patent Foramen Ovale” (hereafter referred to as “the Guidelines”) in 2021. The Guidelines were initiated by Professor Yushun Zhang of the No.1 Affiliated Hospital of Xi’an Jiaotong University, and 55 domestic experts participated in their discussion and formulation. The Guidelines focus on eight key issues in the prevention of stroke associated with patent foramen ovale (PFO), including definition and epidemiology, anatomical features, ultrasound diagnosis, clinical screening, and prevention and treatment of PFO-associated stroke. The prevention and treatment of PFO-associated stroke include pharmacological prevention, prevention of PFO with transcatheter occlusion and transcatheter occlusion of PFO. Patients with PFO are at elevated risk of perioperative stroke. In China, lung cancer ranks first in incidence among malignant tumors. The number of lung cancer surgeries is increasing each year, and the incidence of PFO in the population is approximately 25%. Although perioperative stroke in patients with lung cancer due to the presence of PFO has rarely been reported, given the high disability rate of stroke, incidence of PFO, and incidence of lung cancer, herein, we consider the Guidelines for the management of perioperative stroke in lung cancer. Our aim is to provide further perspectives in decreasing the risk of perioperative stroke in patients with lung cancer and PFO, to improve their quality of life and increase the safety of surgery

Association analysis of alpha-amylase (AMY) and cathepsin L (CTSL) SNPs with growth traits in giant tiger shrimp Penaeus monodon

Alpha-amylase (AMY) and cathepsin-L (CTSL) were selected as candidate genes for SNP discovery for growth traits of P. monodon. Six SNPs were found in AMY and three in CTSL in P. monodon. Association analyses for the candidate SNPs with important economic traits were performed in populations. That allele A at CTLS-213 SNP, AA, and GA, tended to be associated with increased body weight. Shrimps with genotype GG had significantly smaller CL, CW, and CH values than those with GT and TT genotypes (P < 0.05). While CTLS-820 SNP was found to be significantly associated with CH and FSL (P <0.05). These SNPs will be valid for marker-assisted selection breeding programs in P. monodon

Effects of replacing dietary fishmeal with zymolytic black soldier fly larvae on the growth performance of the mud crab (<em>scylla paramamosain</em>) larvae

Black soldier fly have been shown to be one of the optimal alternatives to fishmeal, but there are few reports on the effects of zymolytic black soldier fly larvae (ZBSFL) on the growth and digestion of crustaceans. An 8-week feeding trial was conducted to evaluate the effects of different replacement levels of ZBFLS on growth performance, body composition, and digestive enzyme activity of the mud crab larvae. Four diets were formulated by replacing fishmeal with 0%, 5%, 10% and 15% ZBSFL in the basal diet. Crab larvae were randomly divided into four groups of three replicates each and fed twice daily. The results showed that the SR of crab larvae was higher than that of the no-substitution group when the substitution rate reached 5% (P < 0.05). There was no significant change in SR when the substitution rate was further increased. Weight growth rate and Specific growth rate were similar, both highest at 10% substitution ratio. The crude protein content of whole crab larvae gradually increased as the proportion of FM substituted by ZBSFL increased. The lipid content of whole crab larvae in the 5% substitution ratio group was significantly higher than that in all other groups (P < 0.05). Meanwhile. The activities of amylase, protease and lipase gradually increased. In this experiment, when the percentage of ZBSFL substitution for FM reached 10%, its growth performance was optimal, with higher SR, less negative effects and more balanced indicators in all aspects. When the substitution rate was further increased, it might increase the digestive burden of the crab and negatively affect its growth

Enhanced daytime secondary aerosol formation driven by gas-particle partitioning in downwind urban plumes

Anthropogenic emissions from city clusters can significantly enhance secondary organic aerosol (SOA) formation in the downwind regions, while the mechanism is poorly understood. To investigate the effect of pollutants within urban plumes on organic aerosol (OA) evolution, a field campaign was conducted at a downwind site of the Pearl River Delta region of China in the fall of 2019. A time-of-flight chemical ionization mass spectrometer coupled with a Filter Inlet for Gases and Aerosol (FIGAERO-CIMS) was used to probe the gas- and particle-phase molecular composition and thermograms of organic compounds. For air masses influenced by urban pollution, strong daytime SOA formation through gas-particle partitioning was observed, resulting in higher OA volatility. The obvious SOA enhancement was mainly attributed to the equilibrium partitioning of non-condensable (C * &ge; 100.5 &mu;g m-3) organic vapors. We speculated that the elevated NOx concentration could suppress the formation of highly oxidized products, resulting in a smooth increase of condensable (C * &lt; 100.5 &mu;g m-3) organic vapors. Evidence showed that urban pollutants (NOx and VOCs) could enhance the oxidizing capacity, while the elevated VOCs was mainly responsible for promoting daytime SOA formation by increasing the RO2 production rate. Our results highlight the important role of urban anthropogenic pollutants in SOA control in the suburban region

A Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis

<div><h3>Background</h3><p>A common genetic variant, rs4939827, located in <em>SMAD7</em>, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results.</p> <h3>Method and Findings</h3><p>We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19–1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-study heterogeneity (all <em>P</em> for heterogeneity <0.1). By stratified analysis, we revealed that ethnicity, sample size, and tumor sites might constitute the source of heterogeneity. The cumulative analysis suggested that evident tendency to significant association was seen with adding study samples over time; whilst, sensitive analysis showed results before and after removal of each study were similar, indicating the highly stability of the current results.</p> <h3>Conclusion</h3><p>Results from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer. Nevertheless, fine-mapping of the susceptibility loci defined by rs4939287 should be imposed to reveal causal variant.</p> </div

Insight-HXMT dedicated 33-day observation of SGR J1935+2154 I. Burst Catalog

Magnetars are neutron stars with extreme magnetic field and sometimes manifest as soft gamma-ray repeaters (SGRs). SGR J1935+2154 is one of the most prolific bursters and the first confirmed source of fast radio burst (i.e. FRB 200428). Encouraged by the discovery of the first X-ray counterpart of FRB, Insight-Hard X-ray Modulation Telescope (Insight-HXMT) implemented a dedicated 33-day long ToO observation of SGR J1935+2154 since April 28, 2020. With the HE, ME, and LE telescopes, Insight-HXMT provides a thorough monitoring of burst activity evolution of SGR J1935+2154, in a very broad energy range (1-250 keV) with high temporal resolution and high sensitivity, resulting in a unique valuable data set for detailed studies of SGR J1935+2154. In this work, we conduct a comprehensive analysis of this observation including detailed burst search, identification and temporal analyses. After carefully removing false triggers, we find a total of 75 bursts from SGR J1935+2154, out of which 70 are single-pulsed. The maximum burst rate is about 56 bursts/day. Both the burst duration and the waiting time between two successive bursts follow log-normal distributions, consistent with previous studies. We also find that bursts with longer duration (some are multi-pulsed) tend to occur during the period with relatively high burst rate. There is no correlation between the waiting time and the fluence or duration of either the former or latter burst. It also seems that there is no correlation between burst duration and hardness ratio, in contrast to some previous reports. In addition, we do not find any X-ray burst associated with any reported radio bursts except for FRB 200428.Comment: 31 pages, 10 figures, accepted for publication in ApJ

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

As China's first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 MeV. It was designed to perform pointing, scanning and gamma-ray burst (GRB) observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed. Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.Comment: 29 pages, 40 figures, 6 tables, to appear in Sci. China-Phys. Mech. Astron. arXiv admin note: text overlap with arXiv:1910.0443