Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation

Background: Circadian clocks are self-sustaining oscillators that coordinate behavior and physiology over a 24 hour period, achieving time-dependent homeostasis with the external environment. The molecular clocks driving circadian rhythmic changes are based on intertwined transcriptional/translational feedback loops that combine with a range of environmental and metabolic stimuli to generate daily internal programing. Understanding how biological rhythms are generated throughout the body and the reasons for their dysregulation can provide avenues for temporally directed therapeutics. Summary: In recent years, microRNAs have been shown to play important roles in the regulation of the circadian clock, particularly in Drosophila , but also in some small animal and human studies. This review will summarize our current understanding of the role of miRNAs during clock regulation, with a particular focus on the control of clock regulated gene expression

Diagenesis of the first member of Canglangpu Formation of the Cambrian Terreneuvian in northern part of the central Sichuan Basin and its influence on porosity

In this paper, taking the first Member of the Canglangpu Formation of the Cambrian Terreneuvian in the northern central Sichuan Basin as an example, the diagenesis and its influence on porosity are systemically studied based on the observations and identifications of cores, casts and cathodoluminescence thin sections. The results show that the rock types of the first member of Canglangpu Formation are various, including mixed rocks, carbonate rocks and clastic rocks. The specific lithology is dominated by sand-bearing oolitic dolomite, sandy oolitic dolomite, sparry oolotic dolomite and fine-grained detrital sandstone. At the same time, the Cang 1 Member has experienced five types of diagenetic environments, including seawater, meteoric water, evaporative seawater, shallow burial, and medium-deep burial diagenetic environments. Moreover, the main diagenetic processes under different diagenetic environments include cementation, dissolution, compaction, chemical compaction, dolomitization and structural fractures. According to the analysis, fabric-selective dissolution in meteoric water diagenetic environment, dolomitization in evaporative seawater environment, and non-fabric-selective dissolution, dolomitization and structural fractures in buried diagenetic environment are beneficial to the development of pores. However, cementation, compaction and chemical compaction in medium and deep burial environments, are unfavorable for the development of pores

Effectiveness of Cotreatment with Kuntai Capsule and Climen for Premature Ovarian Failure: A Meta-Analysis

Objective. To compare the treatment efficacy of Kuntai capsule with Climen only in the therapy of premature ovarian failure. Methods. Randomized controlled trials were electronically retrieved from PubMed, Cochrane Library, Web of science, CBM, CNKI, Wanfang, and Weipu database. In addition, some related papers were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions, and the effective data were analyzed by Revman 5.3 Software. Results. 11 randomized control trials involving 1068 patients were included. Results of meta-analysis showed that E2 (estrogen), the total therapeutic effective rate of the group of Kuntai capsule, and hormone were higher than hormone only. The LH (luteinizing hormone), FSH (follicle-stimulating hormone), and Kupperman score of the group of Kuntai capsule and Climen were lower than Climen only. Conclusion. Available evidence shows that Kuntai capsule with Climen is more effective than Climen in the therapy of premature ovarian failure. Nowadays, the quality of the research studies is low. More large-scaled randomized trials will need to be carried out

Regio- and Diastereoselective Hydrophosphination and Hydroamidation of <i>gem</i>-Difluorocyclopropenes

In this study, concise, efficient, and modular hydrophosphinylation and hydroamidation of gem-difluorocyclopropenes were disclosed in a mild and transition-metal-free pattern. Through this approach, phosphorus, and nitrogen-containing gem-difluorocyclopropanes were produced in moderate to good yields with excellent regio- and diastereoselectivity. Readily available gem-difluorocyclopropenes and nucleophilic reagents, along with inexpensive inorganic bases, were employed. Multiple synthetic applications, including gram-scale and derivatization reactions and modification of bioactive molecules, were subsequently elaborated