Myelodysplastic Syndrome Combined with Systemic Lupus Erythematosus: A Case Report

The literature on myelodysplastic syndrome combined with systemic lupus erythematosus is rarely reported. We reviewed and analysed the clinical data of a patient with myelodysplastic syndrome combined with systemic lupus erythematosus who had skin petechiae and fever as the main symptoms, and reviewed the relevant theories. There may be a close relationship between myelodysplastic syndrome and systemic lupus erythematosus, and further research is needed on the pathogenesis. When patients with autoimmune diseases (including systemic lupus erythematosus) presented with blood cell reduction，it is important to pay attention to them, and early bone marrow examination should be carried out to screen for the presence of hematological malignancies

Public sentiment analysis and topic modeling regarding ChatGPT in mental health on Reddit: Negative sentiments increase over time

In order to uncover users' attitudes towards ChatGPT in mental health, this study examines public opinions about ChatGPT in mental health discussions on Reddit. Researchers used the bert-base-multilingual-uncased-sentiment techniques for sentiment analysis and the BERTopic model for topic modeling. It was found that overall, negative sentiments prevail, followed by positive ones, with neutral sentiments being the least common. The prevalence of negative emotions has increased over time. Negative emotions encompass discussions on ChatGPT providing bad mental health advice, debates on machine vs. human value, the fear of AI, and concerns about Universal Basic Income (UBI). In contrast, positive emotions highlight ChatGPT's effectiveness in counseling, with mentions of keywords like "time" and "wallet." Neutral discussions center around private data concerns. These findings shed light on public attitudes toward ChatGPT in mental health, potentially contributing to the development of trustworthy AI in mental health from the public perspective.Comment: 11 pages.8 figures, 2 table

FairEdge: A Fairness-Oriented Task Offloading Scheme for Iot Applications in Mobile Cloudlet Networks

Mobile cloud computing has emerged as a promising paradigm to facilitate computation-intensive and delay-sensitive mobile applications. Computation offloading services at the edge mobile cloud environment are provided by small-scale cloud infrastructures such as cloudlets. While offloading tasks to in-proximity cloudlets enjoys benefits of lower latency and smaller energy consumption, new issues related to the cloudlets are rising. For instance, unbalanced task distribution and huge load gaps among heterogeneous mobile cloudlets are becoming challenging with respect to network dynamics and distributed task offloading. In this paper, we propose 'FairEdge', a Fairness-oriented computation offloading scheme to enable balanced task distribution for mobile Edge cloudlet networks. By integrating the balls-and-bins theory with fairness index, our solution promotes effective load balancing with limited information at low computation cost. The evaluation results from extensive simulations and experiments with real-world datasets show that FairEdge outperforms conventional task offloading methods, it can achieve a network fairness up to 0.85 and reduce the unbalanced task offload by 50%

Acidification oxidation reagent system optimization on coal seams and stimulation effect evaluation

China has abundant coalbed methane (CBM) resources, and most of them are low-permeability and tight reservoirs, with generally low production rate and small recovery factor. Existing technologies face great challenges to meet the demand on CBM in China. It is desirable to develop new methods to improve the production rate and enhance recovery factor. In addition to physical stimulation methods such as hydraulic fracturing and open-hole cave completion, the use of chemical methods to improve physical properties of coal reservoirs has also been a hot research topic in recent years. Coal reservoir acidification and oxidation technology can promote desorption of gas and enlarge permeability of reservoir. But for different coal rank coal reservoirs, the acidification and oxidation agents need to be optimized and their performance evaluated. Laboratory experiments are conducted to compare and analyze the physical properties coal samples from Baode, Mu’ai, and Xinjiang blocks, including coal rank, texture, macroscopic characteristics, quality, porosity, permeability, element, and mineral composition. The optimal concentration of hydrochloric acid is determined through pre-dissolution experiment of coal powder in acid solution. Then a five-factor and three-level orthogonal experiment for acid solution optimization is designed and performed by using Design-Expert software, which identifies the sensitive factors affecting the dissolution. For the coal samples in Baode, Mu’ai, and Xinjiang blocks, the oxidant types and the corresponding acidification and oxidation agent systems are optimized. Applying these acidification and oxidation agent systems to coal samples from Baode, Mu’ai, and Xinjiang blocks, the change of porosity, permeability, and wettability are compared and analyzed. Finally, through numerical simulation, the gas production is predicted for acidification and oxidation in typical well group in Block Mu’ai. Results show that the acid solution has the best dissolution at a concentration of hydrochloric acid of 3 mol/L to 4 mol/L; Top factors played in the experiment are soaking time, acid type, soaking temperature, coal sample type, and acid concentration, in descending order of importance; The optimal oxidant is a hydrogen peroxide solution with a concentration of 3%; the mixed acidification oxidant formula in Baode block is 10% HCl + 2% CH3COOH + 2% HF + 3% H2O2; The optimal mixed acidification oxidant formula in Mu’ai block is 8% HCl + 2% CH3COOH + 4% HF + 3% H2O2; the optimal mixed acidification oxidant formula in Xinjiang block is 12% HCl + 1% CH3COOH + 1% HF + 3% H2O2; The higher the coal rank, the greater the HF content in the optimal acidification oxidant system. Both acidification and oxidation improve the porosity and permeability of coal samples to some extent, and the improvement in low-rank coal is more significant than that in high-rank coal. Acidification and oxidation have different effects on the wettability of coal: Acidification increases the hydrophilicity of coal, whereas oxidation reduce the hydrophilicity of coal; and the hydrophilicity of coal samples treated by the optimized acidification and oxidation system is weakened. Reservoir simulation results show that acidification and oxidation lead to a recovery factor of 64.64% after 10 years of production, which is 19.72% higher than that without acidification and oxidation. The advantage of acidification and oxidation is 0.97% after 18 years of production. However, the acidification and oxidation saved 8 years of production time to achieve a close final recovery factor, which greatly reduces the operating costs. The optimized acidizing oxidation agent systems for CBM reservoirs with low, medium, and high ranks improved the desorption and permeability of the target reservoirs, and increase well production and recovery factor. This research provides technical support for stimulation practices of CBM reservoirs in the aforementioned blocks in China, as well as similar coal reservoirs in the world

Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice

Gestational folic acid (FA) supplementation has been widely recognized for its benefits in preventing offspring defects, but its effect on postpartum females has not yet been adequately assessed. The occurrence of emotional and cognitive dysfunction is common in postpartum women, and its treatment remains limited. Considering the promising results of FA in various psychiatric disorders both in human and redents, we tested the effect of gestational FA administration on postpartum psychiatric behavioral phenotypes and the implicated brain-related mechanisms in a murine model. FA was administered orally in both the hormone-stimulated-pregnancy (HSP) model and pregnant mice at doses of 1 and 5 mg/kg. Postpartum behavioral results showed that the disorders of cognitive performance, depressive, and anxiety-related behaviors were all alleviated in the 5 mg/kg FA group. However, the general development of their offspring remained unaffected. Immunofluorescence and immunoblot results revealed that FA pretreatment significantly activated the maternal hippocampal BDNF-related pathway. Morphological studies have confirmed that FA promotes hippocampal neurogenesis. Moreover, synaptic plasticity and synaptic transmission are enhanced. All of these hippocampal changes play critical roles in rescuing neuronal function and behaviors. Thus, our data suggest that gestational FA administration has a therapeutic effect that improves cognition and reduces depression and anxiety in a murine postpartum model. This may be developed as a preventive and adjuvant therapeutic option for pregnant women

Leaf Cuticle Can Contribute to Non-Host Resistance to Poplar Leaf Rust

The plant leaf cuticle is a chemically complex but largely waxy outer shell that limits water loss and also prevents some pathogens from gaining access to internal mesophyll. Rust fungi are obligate parasites, and most bypass the cuticle by thigmotropically locating stomata, growing through the stomatal openings, and then parasitizing mesophyll cells with haustoria. It is thought that even non-hosts of a given rust fungus do not resist until their mesophyll cells are contacted in this way. In other words, it is thought that the cuticle plays no role in non-host resistance. Here, we tested the hypothesis that poplar leaf cuticles might contribute to non-host resistance to rust fungi by chemically impeding the germination and growth of urediniosporelings of Melampsora larici-populina. Following an initial survey in China of the resistance of 36 genotypes of various species and interspecific hybrids of Populus to M. larici-populina, we selected three genotypes for the initial test of hypothesis: (1) A Populus purdomii genotype that is fully susceptible; (2) a Populus deltoides cv. ‘I-69’ that is incompletely resistant (i.e., a resistant host); and (3) a Populus tomentosa genotype that is a non-host to M. larici-populina. Urediniospores were assayed for germination in extracts of the cuticles of the three genotypes. Germination was most reduced by the P. tomentosa non-host cuticular extracts that also reduced the growth of germ tubes to 36 times less than that in controls or in the extract of the susceptible P. purdomii. Four cuticular components were identified as putative defense compounds given greater concentrations in P. tomentosa than in P. purdomii: Aucubin, hexakis(trimethylsilyl) ether, catechol, 7,9-Di-tert-buty l-1-oxaspiro (4,5) deca-6, 9-diene-2,8-dione and trifluoroacetamide. These four compounds were then tested, and they reduced urediniospore germination and uredinial density in inoculations of normally susceptible P. purdomii with Melampsora larici-populina. Thus, the cuticle of P. tomentosa can contribute to pre-haustorial, non-host resistance to M. larici-populina

Multifactor analysis of the infiltration characteristics of film hole irrigation under muddy water conditions

Abstract Film hole irrigation under muddy water conditions is a new and effective water-saving irrigation technology. In order to determine the influence of multiple factors on the infiltration process of film hole irrigation under muddy water conditions, 12 sets of indoor infiltration tests were conducted to investigate the effects of four key influencing factors (muddy water sand content, hole diameter, soil bulk density, and infiltration time) on the infiltration characteristics of irrigation with film holes under muddy water conditions, in this study. Based on the experimental data, accurate and effective soil water infiltration and vertical and horizontal wetting front transport models were constructed. Based on the modeling results, the standard regression coefficients of each influencing factor against the fitted parameters were calculated and the effects of the factors on the fitted parameters were analyzed. Error analysis showed that both models could effectively simulate the soil water infiltration process under experimental conditions. Infiltration time was the dominant factor influencing the cumulative infiltration per unit of film hole area, followed by hole diameter, muddy water sand content and lastly, soil bulk density. Infiltration time was also the main influencing factor of the vertical wetting front transport distance, followed by soil bulk density, muddy water sand content, and lastly, hole diameter. Similarly, infiltration time exerted the greatest effect on the horizontal transport distance, followed by hole diameter, soil bulk density and muddy water sand content. The model validation revealed that both the calculated and measured values were distributed around the 1:1 line, reflecting the accuracy of the models. The results of this study can provide theoretical support for the design of film hole irrigation systems under muddy water conditions

A case of generalized acute cutaneous lupus erythematosus

A case of acute cutaneous lupus erythematosus is reported. A 75-year-old male presented with asymptomatic erythema on both the ears and face for over a month. Dermatological examination showed fused erythema on both sides of the face and ears. Multiple erythema, maculae and red papules in different sizes were seen on the back, and some lesions were accompanied with scales. Under a dermoscope, there were perifollicular white halos and amorphous areas with scales on red background. Histopathological examination of facial skin lesions showed epidermal atrophy and liquefaction degeneration of the basal cells, and perivascular infiltration of lymphocytes in the superficial and middle dermis. Alcian blue staining was focally positive in the dermis. Diagnosis: generalized acute cutaneous lupus erythematosus. Satisfactory results were achieved after oral administration of hydroxychloroquine combined with methylprednisolone tablets. No recurrence was observed during follow-up