43 research outputs found

    Avenues of art history Recent developments in English art history, with special reference to the works of Francis Haskell and their possible application to the study of Chinese art history

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    SIGLEAvailable from British Library Document Supply Centre- DSC:D186381 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

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    Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD
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