36,869 research outputs found
Criticality and Continuity of Explosive Site Percolation in Random Networks
This Letter studies the critical point as well as the discontinuity of a
class of explosive site percolation in Erd\"{o}s and R\'{e}nyi (ER) random
network. The class of the percolation is implemented by introducing a best-of-m
rule. Two major results are found: i). For any specific , the critical
percolation point scales with the average degree of the network while its
exponent associated with is bounded by -1 and . ii).
Discontinuous percolation could occur on sparse networks if and only if
approaches infinite. These results not only generalize some conclusions of
ordinary percolation but also provide new insights to the network robustness.Comment: 5 pages, 5 figure
Relative Entropy: Free Energy Associated with Equilibrium Fluctuations and Nonequilibrium Deviations
Using a one-dimensional macromolecule in aqueous solution as an illustration,
we demonstrate that the relative entropy from information theory, , has a natural role in the energetics of equilibrium and
nonequilibrium conformational fluctuations of the single molecule. It is
identified as the free energy difference associated with a fluctuating density
in equilibrium, and is associated with the distribution deviate from the
equilibrium in nonequilibrium relaxation. This result can be generalized to any
other isothermal macromolecular systems using the mathematical theories of
large deviations and Markov processes, and at the same time provides the
well-known mathematical results with an interesting physical interpretations.Comment: 5 page
Structure of Stochastic Dynamics near Fixed Points
We analyze the structure of stochastic dynamics near either a stable or
unstable fixed point, where force can be approximated by linearization. We find
that a cost function that determines a Boltzmann-like stationary distribution
can always be defined near it. Such a stationary distribution does not need to
satisfy the usual detailed balance condition, but might have instead a
divergence-free probability current. In the linear case the force can be split
into two parts, one of which gives detailed balance with the diffusive motion,
while the other induces cyclic motion on surfaces of constant cost function.
Using the Jordan transformation for the force matrix, we find an explicit
construction of the cost function. We discuss singularities of the
transformation and their consequences for the stationary distribution. This
Boltzmann-like distribution may be not unique, and nonlinear effects and
boundary conditions may change the distribution and induce additional currents
even in the neighborhood of a fixed point.Comment: 7 page
Generalized Haldane Equation and Fluctuation Theorem in the Steady State Cycle Kinetics of Single Enzymes
Enyzme kinetics are cyclic. We study a Markov renewal process model of
single-enzyme turnover in nonequilibrium steady-state (NESS) with sustained
concentrations for substrates and products. We show that the forward and
backward cycle times have idential non-exponential distributions:
\QQ_+(t)=\QQ_-(t). This equation generalizes the Haldane relation in
reversible enzyme kinetics. In terms of the probabilities for the forward
() and backward () cycles, is shown to be the
chemical driving force of the NESS, . More interestingly, the moment
generating function of the stochastic number of substrate cycle ,
follows the fluctuation theorem in the form of
Kurchan-Lebowitz-Spohn-type symmetry. When $\lambda$ = $\Delta\mu/k_BT$, we
obtain the Jarzynski-Hatano-Sasa-type equality:
1 for all , where is the fluctuating chemical work
done for sustaining the NESS. This theory suggests possible methods to
experimentally determine the nonequilibrium driving force {\it in situ} from
turnover data via single-molecule enzymology.Comment: 4 pages, 3 figure
Stochastic Physics, Complex Systems and Biology
In complex systems, the interplay between nonlinear and stochastic dynamics,
e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in
Darwinian sense, in terms of discrete jumps among attractors, with punctuated
equilibrium, spontaneous random "mutations" and "adaptations". On an
evlutionary time scale it produces sustainable diversity among individuals in a
homogeneous population rather than convergence as usually predicted by a
deterministic dynamics. The emergent discrete states in such a system, i.e.,
attractors, have natural robustness against both internal and external
perturbations. Phenotypic states of a biological cell, a mesoscopic nonlinear
stochastic open biochemical system, could be understood through such a
perspective.Comment: 10 page
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