New New-Phenomena Results from Dzero

We have searched for diphoton events (\ggmet) with large missing transverse momentum, $\gamma\rlap{\kern0.25em/}E_T$ events (\gmetjj) with two or more jets, and diphoton events ($\gamma\gamma$) with high transverse energies in $p\bar p$ collisions at $\sqrt{s} = 1.8$ TeV using approximately 100~pb$^{-1}$ of data collected with the D\O detector at the Fermilab Tevatron in 1992--1996. No excess of events beyond the expected backgrounds is observed. The null results are interpreted in supersymmetric models with a dominant $\tilde\chi^0_2\to\gamma\tilde\chi^0_1$ decay and in terms of Dirac pointlike monopole production.Comment: 11 pages, 6 figures, Presented at the 1998 Rencontres de Physique de la Vallee d'Aoste, La Thuile, Italy, March 1-7, 199

The startup of Run II: Status of Tevatron, CDF, and DØ

I briefly summarize the current status of Tevatron Run II, and highlight a few preliminary results from the CDF and DØ experiments.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47879/1/10052_2004_Article_1903.pd

Kondo behavior and metamagnetic phase transition in a heavy fermion compound CeBi2

Heavy fermions represent an archetypal example of strongly correlated electron systems which, due to entanglement among different interactions, often exhibit exotic and fascinating physics involving Kondo screening, magnetism and unconventional superconductivity. Here we report a comprehensive study on the transport and thermodynamic properties of a cerium-based heavy fermion compound CeBi$_2$ which undergoes an anti-ferromagnetic transition at $T_N$ $\sim$ 3.3 K. Its high temperature paramagnetic state is characterized by an enhanced heat capacity with Sommerfeld coefficient $\gamma$ over 200 mJ/molK$^2$. The magnetization in the magnetically ordered state features a metamagnetic transition. Remarkably, a large negative magnetoresistance associated with the magnetism was observed in a wide temperature and field-angle range. Collectively, CeBi$_2$ may serve as an intriguing system to study the interplay between $f$ electrons and the itinerant Fermi sea.Comment: 7 pages, 6 figure

A comparative study of short-term efficacy and safety for thyroid micropapillary carcinoma patients after microwave ablation or surgery.

Background: Although papillary thyroid microcarcinoma (PTMC) has a high incidence and excellent clinical outcome, debate continues as to the therapeutic approach that would be most appropriate after confirming the diagnosis. Methods: We retrospectively analyzed the medical records of 311 patients with T1aN0M0 PTMC between January 2013 and September 2018. In all, 168 underwent microwave ablation (MWA), and 143 underwent surgery. MWA was performed using extensive ablation with hydrodissection. The surgery comprised thyroid lobectomy (TL) with unilateral central lymph node dissection (CND). We examined clinical outcomes during mean follow-up periods of 824 ± 452 days for the TL group and 753 ± 520 days for the MWA group. Results: Postprocedural follow-up revealed that, in the MWA group, the tumors had completely disappeared in 34 patients, and the remainder were reduced to necrotic or carbonized tissue. The incidence of transient hypoparathyroidism was significantly lower in the MWA group than in the TL group (p \u3c .001). In addition, during the follow-up, we found no statistically significant differences between the two groups (TL vs MWA) for PTMC recurrence (1 vs 2 cases), lymph node metastasis (5 vs 5 cases), or disease-free survival [2001 days (5.5 years) vs 1702 days (4.7 years)] (p = .659, p = .795, and p = .974, respectively). Conclusions: If low-risk thyroid carcinoma (i.e., T1N0M0 PTMC) is accurately diagnosed early, MWA could be a minimally invasive alternative to surgery based on our short-term follow-up regarding recurrence and the low rates of complications and disease-free survival

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

Neutrophils are the most abundant innate immune cells in human circulation; however, their derived exosomes have been rarely studied for tumor treatment. Here, we reported that exosomes from neutrophils (N-Ex) induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway. In addition, we decorated N-Ex with superparamagnetic iron oxide nanoparticles ( SPIONs) to achieve higher tumor-targeting therapeutic effect. We further fabricated exosome-like nanovesicles from neutrophils (NNVs) at high yield. Compared with liposome-loaded doxorubicin (DOX) and natural NNVs, DOX-loaded NNVs show an improved inhibition of tumor cell proliferation. Moreover, DOX-loaded, SPION-decorated NNVs selectively accumulate at the tumor sites under an external magnetic field, effectively restraining tumor growth and extensively prolonging the survival rate in mice. Overall, a simple and effective method to engineer N-Ex and NNVs at clinical applicable scale was developed, which enables the efficient and safe drug delivery for targeted and combined tumor therapy.Peer reviewe