A generic theory for Majorana zero modes in 2D superconductors

It is well known that non-Abelian Majorana zero modes (MZM) harbor at vortex cores in a $p_{x}+\text{i}p_{y}$ topological superconductor, which can be realized in a 2D spin-orbit coupled system with a single Fermi surface and by proximity coupling to an $s$-wave superconductor. Here we show that existence of non-Abelian MZMs is unrelated to the bulk topology of a 2D superconductor, and propose that such exotic modes can be resulted in much broader range of superconductors, being topological or trivial. For a generic 2D system with multiple Fermi surfaces and gapped out by superconducting pairings, we show that at least a single MZM survives if there are only odd number of Fermi surfaces of which the corresponding superconducting orders have vortices, and such MZM is protected by an emergent Chern-Simons invariant, irrespective of the bulk topology of the superconductor. This result may enrich new experimental schemes for realizing non-Aelian MZMs. In particular, we propose a minimal scheme to realize the MZMs in a 2D superconducting Dirac semimetal with trivial bulk topology, which can be well achieved based on the recent cold atom experiments.Comment: 5 pages, 3 figures, plus Supplementary Materia

Glc-TOR signalling leads transcriptome reprogramming and meristem activation

Meristems encompass stem/progenitor cells that sustain postembryonic growth of all plant organs. How meristems are activated and sustained by nutrient signalling remains enigmatic in photosynthetic plants. Combining chemical manipulations and chemical genetics at the photoautotrophic transition checkpoint, we reveal that shoot photosynthesis-derived glucose drives target-of-rapamycin (TOR) signalling relays through glycolysis and mitochondrial bioenergetics to control root meristem activation, which is decoupled from direct glucose sensing, growth-hormone signalling, and stem-cell maintenance. Surprisingly, glucose-TOR signalling dictates transcriptional reprogramming of remarkable gene sets involved in central and secondary metabolism, cell cycle, transcription, signalling, transport and folding. Systems, cellular and genetic analyses uncover TOR phosphorylation of E2Fa transcription factor for an unconventional activation of S-phase genes, and glucose-signalling defects in e2fa root meristems. Our findings establish pivotal roles of glucose-TOR signalling in unprecedented transcriptional networks wiring central metabolism and biosynthesis for energy and biomass production, and integrating localized stem/progenitor-cell proliferation through inter-organ nutrient coordination to control developmental transition and growth

Contactless Haptic Display Through Magnetic Field Control

Haptic rendering enables people to touch, perceive, and manipulate virtual objects in a virtual environment. Using six cascaded identical hollow disk electromagnets and a small permanent magnet attached to an operator's finger, this paper proposes and develops an untethered haptic interface through magnetic field control. The concentric hole inside the six cascaded electromagnets provides the workspace, where the 3D position of the permanent magnet is tracked with a Microsoft Kinect sensor. The driving currents of six cascaded electromagnets are calculated in real-time for generating the desired magnetic force. Offline data from an FEA (finite element analysis) based simulation, determines the relationship between the magnetic force, the driving currents, and the position of the permanent magnet. A set of experiments including the virtual object recognition experiment, the virtual surface identification experiment, and the user perception evaluation experiment were conducted to demonstrate the proposed system, where Microsoft HoloLens holographic glasses are used for visual rendering. The proposed magnetic haptic display leads to an untethered and non-contact interface for natural haptic rendering applications, which overcomes the constraints of mechanical linkages in tool-based traditional haptic devices

Recombinant EXLX1 from Bacillus subtilis for enhancing enzymatic hydrolysis of corn stover with low cellulase loadings

BsEXLX1 protein from Bacillus subtilis has been proposed to have a structure that is similar to plant expansin. In this study, the recombinant BsEXLX1 protein was successfully expressed and purified in Escherichia coli BL21 (DE3). When the purified BsEXLX1 which contained the thioredoxin (Trx) protein was incubated with low-dose cellulases either simultaneously or sequentially, it showed a significant synergistic activity in corn stover hydrolysis. Furthermore, an even greater increase in the synergistic activity was obtained when cellulose was pretreated with BsEXLX1 followed by cellulase hydrolysis, and the synergistic activity was found as high as 1.5-fold greater than that when cellulose was treated simultaneously with the same concentrations of BsEXLX1 and cellulases. These results provided a feasible way for the potential application of BsEXLX1 in the efficient saccharification of cellulose materials for bioethanol production.Key word: Bacillus subtilis, BsEXLX1, cellulase, cellulose hydrolysis, bioethano

Cost-Effective Incentive Allocation via Structured Counterfactual Inference

We address a practical problem ubiquitous in modern marketing campaigns, in which a central agent tries to learn a policy for allocating strategic financial incentives to customers and observes only bandit feedback. In contrast to traditional policy optimization frameworks, we take into account the additional reward structure and budget constraints common in this setting, and develop a new two-step method for solving this constrained counterfactual policy optimization problem. Our method first casts the reward estimation problem as a domain adaptation problem with supplementary structure, and then subsequently uses the estimators for optimizing the policy with constraints. We also establish theoretical error bounds for our estimation procedure and we empirically show that the approach leads to significant improvement on both synthetic and real datasets

Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword

Abstract Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the vasculature, has emerged as an active component of the blood vessel wall regulating vascular homeostasis and affecting the pathogenesis of atherosclerosis. Although PVAT characteristics resemble both brown and white adipose tissues, recent evidence suggests that PVAT develops from its own distinct precursors implying a closer link between PVAT and vascular system. Under physiological conditions, PVAT has potent anti-atherogenic properties mediated by its ability to secrete various biologically active factors that induce non-shivering thermogenesis and metabolize fatty acids. In contrast, under pathological conditions (mainly obesity), PVAT becomes dysfunctional, loses its thermogenic capacity and secretes pro-inflammatory adipokines that induce endothelial dysfunction and infiltration of inflammatory cells, promoting atherosclerosis development. Since PVAT plays crucial roles in regulating key steps of atherosclerosis development, it may constitute a novel therapeutic target for the prevention and treatment of atherosclerosis. Here, we review the current literature regarding the roles of PVAT in the pathogenesis of atherosclerosis.https://deepblue.lib.umich.edu/bitstream/2027.42/145729/1/12933_2018_Article_777.pd

Anomalous superconducting proximity effect of planar Pb-RhPb2 heterojunctions in the clean limit

Interest in superconducting proximity effect has been revived by the exploitation of Andreev states and by the possible emergence of Majorana bound states at the interface. Spectroscopy of these states has been so far restricted to just a handful of superconductor-metal systems in the diffusion regime, whereas reports in otherwise clean superconductor-superconductor heterojunctions are scarce. Here, we realize molecular beam epitaxy growth of atomically sharp planar heterojunctions between Pb and a topological superconductor candidate RhPb2 that allows us to spectroscopically image the proximity effect in the clean limit. The measured energy spectra of RhPb2 vary with the spatial separation from proximal Pb, and exhibit unusual modifications in the pairing gap structure and size that extend over a distance far beyond the coherence length. This anomalously long-range proximity (LRP) effect breaks the rotational symmetry of Cooper pair potential in real space and largely deforms the Abrikosov vortex cores. Our work opens promising avenues for fundamental studies of the Andreev physics and extraordinary states in clean superconducting heterojunctions.Comment: 8 pages, 4 figure