Adherence to a healthy lifestyle and its association with cognitive impairment in community-dwelling older adults in Shanghai

IntroductionThere is a growing body of recent literature linking the association of specific or multiple lifestyles with cognitive impairment, but most of these studies have been conducted in Western populations, and it is necessary to study multiple lifestyles and cognitive abilities in different populations, with the primary population of this study being a select group of community-dwelling older adults in Shanghai, China.MethodsThe sample included 2,390 community-dwelling Chinese participants. Their cognitive function was assessed using the Mini-Mental State Examination (MMSE). We defined a healthy lifestyle score on the basis of being non-smoking, performing ≥210 min/wk moderate/vigorous-intensity physical activity, having light to moderate alcohol consumption, eating vegetables and fruits daily, having a body mass index (BMI) of 18.5–23.9 kg/m2, and having a waist-to-hip ratio (WHR) <0.90 for men and <0.85 for women, for an overall score ranging from 0 to 6.ResultsCompared with participants with ≤2 healthy lifestyle factors, the adjusted odds ratio (OR) and 95% confidence interval (CI) for participants with 4, 5, and 6 healthy lifestyle factors were 0.53 (95% CI, 0.29–0.98), 0.40 (95% CI, 0.21–0.75), and 0.36 (95% CI, 0.16–0.79), respectively. Only WHR (OR = 0.54, 95% CI = 0.37–0.78) and physical activity (OR = 0.69, 95% CI = 0.51–0.92) were associated with cognitive impairment. A healthy lifestyle correlated with overall cognition (β = 0.066, orientation (β = 0.049), language ability (β = 0.060), delayed recall (β = 0.045) and executive function (β = 0.044) (P all < 0.05).ConclusionThe study provides evidence on an inverse association between healthy lifestyles and cognitive impairment. We investigated whether healthy lifestyle was related to specific cognitive functions to provide a theoretical basis for accurate clinical prescription

Analysis of crucial molecules involved in herniated discs and degenerative disc disease

OBJECTIVES: Herniated discs and degenerative disc disease are major health problems worldwide. However, their pathogenesis remains obscure. This study aimed to explore the molecular mechanisms of these ailments and to identify underlying therapeutic targets. MATERIAL AND METHODS: Using the GSE23130 microarray datasets downloaded from the Gene Expression Omnibus database, differentially co-expressed genes and links were identified using the differentially co-expressed gene and link method with a false discovery rate ,0.25 as a significant threshold. Subsequently, the underlying molecular mechanisms of the differential co-expression of these genes were investigated using Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. In addition, the transcriptional regulatory relationship was also investigated. RESULTS: Through the analysis of the gene expression profiles of different specimens from patients with these diseases, 539 differentially co-expressed genes were identified for these ailments. The ten most significant signaling pathways involving the differentially co-expressed genes were identified by enrichment analysis. Among these pathways, apoptosis and extracellular matrix-receptor interaction pathways have been reported to be related to these diseases. A total of 62 pairs of regulatory relationships between transcription factors and their target genes were identified as critical for the pathogenesis of these diseases. CONCLUSION: The results of our study will help to identify the mechanisms responsible for herniated discs and degenerative disc disease and provides a theoretical basis for further therapeutic study

Branching fractions of B−→D−X0,1(2900)B^-\to D^-X_{0,1}(2900) and their implications

The exotic states $X_{0,1}(2900)$ with the quark flavor of $cs\bar{u}\bar{d}$ are recently observed in the mass spectrum of $D^+K^-$ in $B^-\to D^-D^+K^-$ by the LHCb collaboration. To explore the nature of $X_{0,1}(2900)$, except for analyzing their masses and decay widths as usually did in literatures, the study of their production mechanism in $B$-meson weak decays would provide another important information. The amplitude of $B^-\to D^- X_{0,1}$ is non-factorizable. We consider the final-state-interaction effects and calculate them via the rescattering mechanism. The measured branching fractions of $B^-\to D^- X_{0,1}$ are revealed. It is manifested by ${B}^-\to \Lambda_c^-\Xi_c^{(\prime)0}$ and $\Lambda_b^0\to P_c^+K^-$ that the rescattering mechanism can result in the relatively large branching fractions. The similar processes of $B^-\to \pi^-X_{0,1}$ are also analyzed. The isospins of $X_{0,1}$ can be investigated by $B\to DX_{0,1}^{\pm,0}$ decays.Comment: 12 pages, 10 figures. Version published in EPJC. Additional contributions are added in $B\to \pi X_{0,1}$ in Fig.8. Numerical results of the isospin-partner processes are changed by a factor of 2 in Eqs.(12) and (13

Topological optimization of hybrid quantum key distribution networks

With the growing complexity of quantum key distribution (QKD) network structures, aforehand topology design is of great significance to support a large-number of nodes over a large-spatial area. However, the exclusivity of quantum channels, the limitation of key generation capabilities, the variety of QKD protocols and the necessity of untrusted-relay selection, make the optimal topology design a very complicated task. In this research, a hybrid QKD network is studied for the first time from the perspective of topology, by analyzing the topological differences of various QKD protocols. In addition, to make full use of hybrid networking, an analytical model for optimal topology calculation is proposed, to reach the goal of best secure communication service by optimizing the deployment of various QKD devices and the selection of untrusted-relays under a given cost limit. Plentiful simulation results show that hybrid networking and untrusted-relay selection can bring great performance advantages, and then the universality and effectiveness of the proposed analytical model are verified.Comment: 12 pages, 4 figure

Development of Space-Time-Controlled Multi-Stage Pulsed Magnetic Field Forming and Manufacturing Technology at the WHMFC*

In November 2011, the Project of Basic Research of Forming by Space-Time-Controlled Multi-Stage Pulsed Magnetic Field (Stic-Must-PMF) was supported by the National Basic Research Program of China (973 Project, 2011.11-2016.08). It is aimed at achieving breakthroughs in manufacturing technology to solve current problems in forming largescale and complex sheet and tube parts and components, imposed by the limitations of existing equipment and materials forming properties. The objective of our research group focuses on the design principles and structural layout optimization of Stic-Must-PMF facility. And this paper will report the development of Stic-Must-PMF forming and manufacturing technology at the Wuhan National High Magnetic Field Center (WHMFC) including numerical modeling, experimental setup and experimental studies

Detection of micrometastases in peripheral blood of non-small cell lung cancer with a refined immunomagnetic nanoparticle enrichment assay

Fe3O4 particles are currently used as the core of immunomagnetic microspheres in the immunomagnetic enrichment assay of circulating tumor cells (CTCs). It is difficult to further improve the sensitivity of CTC detection or to improve tumor cell-type identification and characterization. In the present study, we prepared immunomagnetic nanoparticles with nanopure iron as the core, coated with anti-cytokeratin 7/8 (CK7/8) monoclonal antibody. These immunomagnetic nanoparticles (IMPs) were used in conjunction with immunocytochemistry (ICC) to establish a refined immunomagnetic nanoparticle enrichment assay for CTC detection in non-small cell lung cancer (NSCLC). The assay was compared with nested reverse transcription polymerase chain reaction (RT-PCR) to detect CK19 mRNA and lung specific X protein (LUNX) mRNA. Human lung adenocarcinoma cell line A549 was used for sensitivity and specificity evaluation. Peripheral blood samples were collected from each group for CTC detection. The average diameter of the immunomagnetic nanoparticles was 51 nm, and the amount of adsorbed antibodies was 111.2 μg/mg. We could detect down to one tumor cell in 5 × 107 peripheral blood mononuclear cells. The sensitivity was consistent with that of nested RT-PCR; however, the false positive rate was significantly reduced. The modified assay combined with ICC did not differ from nested RT-PCR in sensitivity, but it had significantly increased specificity. This approach could, therefore, contribute to identification of micrometastases, re-defining clinical staging, and guiding individual postoperative treatments. The technique shows considerable potential clinical value and further clinical trials are warranted

Outcomes of two types of iodine-125 seed delivery with metal stents in treating malignant biliary obstruction: a systematic review and meta-analysis

PURPOSETo conduct a meta-analysis comparing the efficacy and safety of two types of iodine-125 (I-125) seed delivery with metal stents (the study group) versus conventional metal stents (the control group) in patients with malignant biliary obstruction (MBO).METHODSOur team systematically searched the PubMed, Embase, and Cochrane Library databases for relevant studies published from January 2012 up to July 2021. Survival time and stent dysfunction were the primary measured outcomes. Subgroup analyses were conducted according to the type of I-125 seed delivery.RESULTSEleven studies, including 1057 patients in total, were pooled for stent dysfunction. The study group showed a lower risk of stent dysfunction than the control group [odds ratio (OR): 0.61, 95% confidence interval (CI) 0.46–0.81, P = 0.001]. The pooled results of six studies reporting overall survival (OS) showed that the study group had a better survival outcome than the control group [hazard ratio (HR): 0.34, 95% CI: 0.28–0.42, P 0.05). The study group was significantly superior to the control group, with better survival and decreased stent dysfunction. Meanwhile, the delivery of I-125 seeds did not increase adverse events.CONCLUSIONThe delivery of I-125 with metal stents may be considered a preferable technique for MBO