Demonstration of a self-pulsing photonic crystal Fano laser

Semiconductor lasers in use today rely on mirrors based on the reflection at a cleaved facet or Bragg reflection from a periodic stack of layers. Here, we demonstrate an ultra-small laser with a mirror based on the Fano resonance between a continuum of waveguide modes and the discrete resonance of a nanocavity. The Fano resonance leads to unique laser characteristics. Since the Fano mirror is very narrow-band compared to conventional lasers, the laser is single-mode and in particular, it can be modulated via the mirror. We show, experimentally and theoretically, that nonlinearities in the mirror may even promote the generation of a self-sustained train of pulses at gigahertz frequencies, an effect that was previously only observed in macroscopic lasers. Such a source is of interest for a number of applications within integrated photonics

Observation of soliton pulse compression in photonic crystal waveguides

We demonstrate soliton-effect pulse compression in mm-long photonic crystal waveguides resulting from strong anomalous dispersion and self-phase modulation. Compression from 3ps to 580fs, at low pulse energies(~10pJ), is measured via autocorrelation

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Funding WHO

Guaranteed cost static output feedback for networked control systems

© 2014 IEEE. This paper is concerned with the guaranteed cost static output feedback (SOF) control for a networked control system (NCS) in imperfect conditions. First, by analyzing the sampling process in connection with network-induced delays and consecutive data packet dropouts and by introducing a new delay function, we formulate such a NCS as a continuous time delay system with the practical assumption that network delays and consecutive dropouts are bounded. Then, based on the delay-dependent approach, sufficient conditions for the existence of a guaranteed cost SOF controller in the NCS are obtained via a set of non-convex matrix inequalities. A cone complementary linearization (CCL) algorithm is used to solve these inequalities to determine a sub-optimal controller that minimizes the guaranteed cost of the NCS. Simulation results are shown to demonstrate the effectiveness of the proposed method

Customers' preferences and willingness to pay for a future dengue vaccination: a study of the empirical evidence in Vietnam

Trung Quang Vo,1,* Quang Vinh Tran,1,* Nam Xuan Vo2 1Department of Pharmacy Administration, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam; 2Department of Social, Economic and Administrative Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand *These authors contributed equally to this work Background: Dengue was endemic to Vietnam. Due to the lack of a readily available remedy, dengue vaccines (DV) have been used elsewhere to cure the disease. However, introducing DV in Vietnam has met resistance from society and the government, influencing decisions about willingness-to-pay (WTP) and other pharmacoeconomic studies. This research aimed to evaluate the extent to which Vietnamese customers would be willing to pay to vaccinate themselves and their children, if any at all, against dengue.Materials and methods: This was a cross-sectional interview-based research. Contingent valuation method, combined with the bidding technique and several open-ended questions, were used to obtain the maximum WTP values for six hypothetical scenarios of two types of DV (60% efficacy for 10 years, “Type 1” vs 90% efficacy for 20 years, “Type 2”).Results: The median WTP per adult for Type 1 and Type 2 DV were US$130.34 and US$217.39, respectively. The median WTP rates per parent for their own vaccination were US$86.96 (Type 1) and US$156.52 (Type 2), for their children vaccination costs were US$108.70 (Type 1) and US$195.65 (Type 2). Five factors affected the WTP rates: monthly income, marital status, area, locality and level of education.Conclusion: The WTP rates for DV were high, supporting the introduction of DV in Vietnam.Keywords: customer, dengue fever, dengue vaccine, Vietnam, willingness to pay (WTP

Areas of life visualisation: Growing data-reliance

© Springer International Publishing AG 2016. This paper presents a framework to mine and identify the areas of life and the way they are perceived, understood cognitively, and effectively using visualisation and machine learning. We provide an overview of the network of users including their activity and connections as well as zoom and details on demand of each individual areas of life. This research identifies the factors of each area of life which are significant on the user’s social media profile in relation to information associated with each user such as time and location, including dynamic social behaviours. It aims to identify the key psychological factors and salient behaviours in order to find out the psychological factors of the user, and other overheads that can be portrayed in an image

Astaxanthin production by newly isolated Rhodosporidium toruloides: Optimization of medium compositions by response surface methodology

Astaxanthin is a valuable carotenoid pigment, which has been extensively used in various industries. In this study, Rhodosporidium toruloides was first used as a new microbial source for producing natural astaxanthin. Various carbon, nitrogen, and mineral sources were evaluated for their effect on astaxanthin production of R. toruloides. Response surface methodology (RSM) was then used to optimize the medium compositions for maximizing the astaxanthin concentration. Among the examined nutrients, glucose, peptone, and KH2PO4 were the most efficient carbon, nitrogen, and mineral source for astaxanthin production, respectively. Through RSM, a maximum astaxanthin concentration of 927.11 µg l-1 was obtained by using Hansen broth containing 83.74 g l-1 glucose, 20.01 g l-1 peptone, and 6.19 g l-1 KH2PO4. This study suggested that R. toruloides is a promising candidate to produce natural astaxanthin.</jats:p

Vertical flow constructed wetlands using expanded clay and biochar for wastewater remediation: A comparative study and prediction of effluents using machine learning

This study evaluated and compared the performance of two vertical flow constructed wetlands (VF) using expanded clay (VF1) and biochar (VF2), of which both are low-cost, eco-friendly, and exhibit potentially high adsorption as compared to conventional filter layers. Both VFs achieved relatively high removal for organic matters (i.e. Biological oxygen demand during 5 days, BOD5) and nitrogen, accounting for 9.5 - 10.5 g.BOD5.m-2.d-1 and 3.5 - 3.6 g.NH4-N.m-2.d-1, respectively. The different filter materials did not exert any significant discrepancy to effluent quality in terms of suspended solids, organic matters and NO3-N (P > 0.05), but they did influence NH4-N effluent as evidenced by the removal rate of that by VF1 and VF2 being of 82.4 ± 5.7 and 84.6 ± 6.4%, respectively (P 2) and the root mean square error (RMSE) of whole fitting data achieved 74.0% and 5.0 mg.L-1, 80.0% and 0.3 mg.L-1, 90.1% and 2.9 mg.L-1, and 48.5% and 0.5 mg.L-1 for BOD5_VF1, NH4-N_VF1, BOD5_VF2, and NH4-N_VF2, respectively