Perturbation observer based adaptive passive control for damping improvement of multi-terminal voltage source converter-based high voltage direct current systems

This paper proposes a Perturbation Observer-based adaptive passive control (POAPC) for damping improvement of multi-terminal voltage source converter-based high voltage direct current (VSC-MTDC) systems. The POAPC is designed for an N-terminal VSC-MTDC system, and the perturbation is defined as a lumped term including interactions between terminals, unmodelled dynamics and unknown external disturbances, which are estimated online via a perturbation observer. Then an extra system damping is injected for each terminal to improve the transient dynamics via passivation. The POAPC does not require an accurate system model and measurements of full states; only the DC voltage and active and reactive power need to be measured. Case studies are carried out on a four-terminal VSC-MTDC system under four scenarios such as active and reactive power reversal, faults at AC bus, offshore wind farm connection, and fast time-varying parameter uncertainties. Simulation results verify its effectiveness under various operating conditions, compared with that of conventional proportional-integral (PI) control and classical passive control (PC). </jats:p

Wide-Area Damping Controller of FACTS Devices for Inter-Area Oscillations Considering Communication Time Delays

The usage of remote signals obtained from a wide-area measurement system (WAMS) introduces time delays to a wide-area damping controller (WADC), which would degrade system damping and even cause system instability. The time-delay margin is defined as the maximum time delay under which a closed-loop system can remain stable. In this paper, the delay margin is introduced as an additional performance index for the synthesis of classical WADCs for flexible ac transmission systems (FACTS) devices to damp inter-area oscillations. The proposed approach includes three parts: a geometric measure approach for selecting feedback remote signals, a residue method for designing phase-compensation parameters, and a Lyapunov stability criterion and linear matrix inequalities (LMI) for calculating the delay margin and determining the gain of the WADC based on a tradeoff between damping performance and delay margin. Three case studies are undertaken based on a four-machine two-area power system for demonstrating the design principle of the proposed approach, a New England ten-machine 39-bus power system and a 16-machine 68-bus power system for verifying the feasibility on larger and more complex power systems. The simulation results verify the effectiveness of the proposed approach on providing a balance between the delay margin and the damping performance

Searching for Tissue-Specific Expression Pattern-Linked Nucleotides of UGT1A Isoforms

UDP-glucuronosyltransferases 1A isoforms belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds. The nine functional UGT1A isoforms are encoded by a single UGT1A gene locus with multiple first exons. The expression of the UGT1A transcripts was measured by quantitative RT-PCR in 23 normal human tissues. The tissue-specific expression patterns were observed in 13 tissues. To understand the regulation mechanism that is responsible for the tissue-specific expression patterns, we scanned the DNA sequence alignments of the putative promoter regions, exon 1 sequences and intron 1 sequences for those expression-pattern-linked nucleotides. Using one of the expression-pattern-linked nucleotides for livers as an example, we showed that a database comprised of these expression-pattern-linked nucleotides could be used to generate focused hypotheses on the problem of tissue-specific expression, which is critical for tissue-specific pharmacodynamics of anticancer drugs

MHC class I loci of the Bar-Headed goose (Anser indicus)

MHC class I proteins mediate functions in anti-pathogen defense. MHC diversity has already been investigated by many studies in model avian species, but here we chose the bar-headed goose, a worldwide migrant bird, as a non-model avian species. Sequences from exons encoding the peptide-binding region (PBR) of MHC class I molecules were isolated from liver genomic DNA, to investigate variation in these genes. These are the first MHC class I partial sequences of the bar-headed goose to be reported. A preliminary analysis suggests the presence of at least four MHC class I genes, which share great similarity with those of the goose and duck. A phylogenetic analysis of bar-headed goose, goose and duck MHC class I sequences using the NJ method supports the idea that they all cluster within the anseriforms clade