Hyperparathyroidism with presumed sellar-parasellar brown tumour based on imaging findings

Brown tumours are an end-stage complication of hyperparathyroidism. They are relatively rare today, due to earlier diagnosis and prompt treatment of hyperparathyroidism.1 Common locations are the mandible, pelvis, ribs and long bones of the axial skeleton.2 The skull base is an extremely rare site and, for obvious reasons, it is difficult to confirm the diagnosis in the absence of other lesions. In the face of a solitary lesion, a histological diagnosis of a ‘giant-cell tumour’ of benign nature should only be made once hyperparathyroidism has been actively excluded. Brown tumours, solid aneurysmal bone cysts, giant-cell reparative granuloma and giant cell tumour can all appear identical both macroand microscopically

Magnetism dependent phonon anomaly in LaFeAsO observed via inelastic x-ray scattering

The phonon dispersion was measured at room temperature along (0,0,L) in the tetragonal phase of LaFeAsO using inelastic x-ray scattering. Spin-polarized first-principles calculations imposing various types of antiferromagnetic order are in better agreement with the experimental results than nonmagnetic calculations, although the measurements were made well above the magnetic ordering temperature, T_N. Splitting observed between two A_{1g} phonon modes at 22 and 26 meV is only observed in spin-polarized calculations. Magneto-structural effects similar to those observed in the AFe_2As_2 materials are confirmed present in LaFeAsO. The presence of Fe-spin is necessary to find reasonable agreement of the calculations with the measured spectrum well above T_N. On-site Fe and As force constants show significant softening compared to nonmagnetic calculations, however an investigation of the real-space force constants associates the magnetoelastic coupling with a complex renormalization instead of softening of a specific pairwise force.Comment: 7 pages, 4 figure

Effects of asymmetric creep-ageing behaviour on springback of AA2050-T34 after creep age forming

This study investigates the effects of asymmetric creep-ageing behaviour on springback of aluminium alloys during creep age forming (CAF) process. An Al-Cu-Li alloy, AA2050, which shows an apparent asymmetric tension and compression creep-ageing behaviour is used for investigation. Several CAF trial tests to form singly-curved AA2050 plates with different thicknesses (3, 5 and 8 mm) are carried out with a four point bending setup. Meanwhile, two sets of finite element (FE) models of corresponding processes have been developed, in which either the conventional symmetric or the new asymmetric creep-ageing behaviour of the alloy was used. The asymmetric models can well predict the shape of formed plates for thicker materials (5 and 8 mm), while symmetric models provide over-prediction of final deflections. The results from asymmetric models indicate that more creep strain is generated in the tension stressed part of the forming plate than that in the other part with compressive stresses and therefore, resulting in an asymmetric distribution of the relaxed stresses through the thickness of the forming plates after creep-ageing. After springback, both top and bottom surfaces of the formed plates show significant compressive stresses while tensile residual stresses exist in the centre of the formed plates. The work in this study helps to understand the particular springback behaviour of AA2050 with asymmetric creep-ageing behaviour in CAF, and can be used to guide future industrial applications of the alloy in the CAF process

LNK (SH2B3): paradoxical effects in ovarian cancer.

LNK (SH2B3) is an adaptor protein studied extensively in normal and malignant hematopoietic cells. In these cells, it downregulates activated tyrosine kinases at the cell surface resulting in an antiproliferative effect. To date, no studies have examined activities of LNK in solid tumors. In this study, we found by in silico analysis and staining tissue arrays that the levels of LNK expression were elevated in high-grade ovarian cancer. To test the functional importance of this observation, LNK was either overexpressed or silenced in several ovarian cancer cell lines. Remarkably, overexpression of LNK rendered the cells resistant to death induced by either serum starvation or nutrient deprivation, and generated larger tumors using a murine xenograft model. In contrast, silencing of LNK decreased ovarian cancer cell growth in vitro and in vivo. Western blot studies indicated that overexpression of LNK upregulated and extended the transduction of the mitogenic signal, whereas silencing of LNK produced the opposite effects. Furthermore, forced expression of LNK reduced cell size, inhibited cell migration and markedly enhanced cell adhesion. Liquid chromatography-mass spectroscopy identified 14-3-3 as one of the LNK-binding partners. Our results suggest that in contrast to the findings in hematologic malignancies, the adaptor protein LNK acts as a positive signal transduction modulator in ovarian cancers