L’Intelligence Collective dans la Conception et le Déploiement d’une Unité d’Enseignement Transversale et Interdisciplinaire à Grande Échelle : l’UE CATI

L’Unité d’Enseignement (UE) CATI est basée sur l’apprentissage par projets, la transversalité et l’interdisciplinarité de sa conception jusqu’à sa valorisation. Expérimentées pour la première2fois en 2020-2021 pour les 1086 étudiants de 1ʳᵉ année de licence inscrits au sein de l’institut sciences et techniques de CY Cergy Paris Université (CY), la construction et la réalisation en apprentissage par projet d’une UE interdisciplinaire de cette envergure ont été rendues possibles par l’implication de plusieurs acteurs, en mobilisant les principes de l’intelligence collective.Dans cet article, nous indiquerons comment l’intégration des principes de l’intelligence collective à toutes les étapes a permis d’engager et de mettre en mouvement ces différents acteurs : la conception de l’UE par 15 enseignants issus de 8 départements disciplinaires, sa mise en oeuvre/animation par 44 étudiants-tuteurs, eux-mêmes accompagnés par deux services distincts de l’université, a permis au millier d’étudiants de 1ʳᵉ année organisés en 143 groupes autonomes, de travailler en apprentissage par projet, de produire dans les délais imposés des livrables ancrés dans des problématiques sociétales et territoriales

Synthèse d'une nouvelle famille de diaminocarbènes chiraux et utilisation en catalyse asymétrique

PARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

Unusually facile palladium catalysed oxidation of imidazolidines and oxazolidines

An unusually facile palladium catalysed oxidation of imidazolidines is described, affording in good yield, the monoamide of the corresponding diamine or the corresponding imidazolines. Oxazolidines derived from ephedrine react similarly

Asymmetric Synthesis withN-Heterocyclic Carbenes. Application to the Copper-Catalyzed Conjugate Addition

International audienceChiral N-heterocyclic carbenes are good ligands for the copper-catalyzed conjugate addition of dialkylzinc reagents to various Michael acceptors. With as little as 4% of chiral ligand, the enantioselectivity may reach 93% on cycloheptenone

Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide

The incorporation into a peptide chain of highly hindered and weakly nucleophilic trifluoromethylated prolines, pseudoprolines and oxazolidines has been achieved. As an application, the synthesis of a new class of fluorinated analogues of the neuroprotective tripeptide glycine-proline-glutamate (GPE) is reported. These analogues have been elaborated from a panel of five-membered ring trifluoromethylated amino acids (Tfm-AAs) through the coupling reaction with a glutamate residue at the <i>C</i>-terminus and a glycine at the <i>N</i>-terminus. Although the peptide coupling reaction at the <i>C</i>-terminal position of the fluorinated amino acid was conveniently performed under standard conditions, the very challenging coupling reaction at the highly deactivated <i>N</i>-terminal position proved to be much more problematic. A methodological study was needed to identify suitable reaction conditions for this difficult peptide coupling

Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes

International audienceThe preparation of a variety of chiral N-heterocyclic carbene (NHC) precursors is described. The relative merits of imidazolinium salts and silver carbenes as NHC precursors are discussed with respect to their synthesis, stability and performance in the copper catalysed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors. Enantioselectivities of up to 93% were achieved using as little as 4% of chiral ligand. (c) 2005 Elsevier B.V. All rights reserved

Crystallization-Induced Dynamic Resolution of Fox Chiral Auxiliary and Application to the Diastereoselective Electrophilic Fluorination of Amide Enolates

A highly efficient crystallization-induced dynamic resolution (CIDR) of <i>trans</i>-<b>Fox</b> (fluorinated oxazolidine) chiral auxiliary is reported. This chiral auxiliary was used for highly diastereoselective (>98% <i>de</i>) electrophilic fluorination of amide enolates. After removal of the chiral auxiliary, highly valuable enantiopure α-fluorocarboxylic acids and β-fluoroalcohols are obtained