Communications Biophysics

Contains research objectives and reports on three research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grant MH-04737-02

Harvard MS Richardson 23: A «Pendant» to Vatican MS Urb. lat. 276 and a Significant Exemplar for P. C. Decembrio's Opuscula historica

Pyle Cynthia-M. Harvard MS Richardson 23: A «Pendant» to Vatican MS Urb. lat. 276 and a Significant Exemplar for P. C. Decembrio's Opuscula historica. In: Scriptorium, Tome 42 n°2, 1988. pp. 191-198

A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder

Bulimia nervosa (BN) and alcohol use disorder (AUD) frequently co-occur and may share genetic factors; however, the nature of their association is not fully understood. We assessed the extent to which the same genetic and environmental factors contribute to liability to BN and AUD. A bivariate structural equation model using a Cholesky decomposition was fit to data from 7,241 women who participated in the Swedish Twin study of Adults: Genes and Environment. The proportion of variance accounted for by genetic and environmental factors for BN and AUD and the genetic and environmental correlations between these disorders were estimated. In the best-fitting model, the heritability estimates were 0.55 (95% CI: 0.37; 0.70) for BN and 0.62 (95% CI: 0.54; 0.70) for AUD. Unique environmental factors accounted for the remainder of variance for BN. The genetic correlation between BN and AUD was 0.23 (95% CI: 0.01; 0.44), and the correlation between the unique environmental factors for the two disorders was 0.35 (95% CI: 0.08; 0.61), suggesting moderate overlap in these factors. Findings from this investigation provide additional support that some of the same genetic factors may influence liability to both BN and AUD