El curanderismo y el campo de la salud en Brasil

Objetivos: Describir el poder médico hegemónico en el campo de la salud, así como examinar sus relaciones con las prácticas de curanderismo en Brasil

Neurophysiological background for physical therapies in fibromyalgia

This paper describes the techniques for controlling pain by the physical means that are most widely used clinically, particularly in the case of fibromyalgia. They are grouped on the basis of the physical energy used: mechanical, thermal (including magnetic and electromagnetic), and light (LASER). The main underlying neu-rophysiological mechanisms are gate activation, the stimulation of descending systems of pain control, and the endogenous opiate system

Pain in systemic sclerosis

Chronic pain is a healthcare problem that significantly affects the mental health, and the professional and private life of patients. It can complicate many disorders and represents a common symptom of rheumatologic diseases, but the data on its prevalence is still limited. Pain is a ubiquitous problem in systemic sclerosis (SSc). SSc-related pain has been studied on the basis of biomedical models and is considered a symptom caused by the disease activity or previous tissue damage. Effective pain management is a primary goal of the treatment strategy, although this symptom in SSc has not yet been investigated in detail. However, these patients do not all respond adequately to pharmacological pain therapies, therefore in these cases a multimodal approach needs to be adopted

Reumatismo : cambio della guardia

Cosa significa prendere nelle mani la direzione di una delle pi\uf9 antiche riviste di reumatologia al mondo? Un ritorno al passato ed un tuffo nel futuro: nel passato ritrovo il ricordo di uno specializzando in reumatologia alle prime armi coinvolto nella redazione di Reumatismo, diretta allora dal Prof. Vittorio Bianchi. Nel futuro alcune idee e progetti ambiziosi per rendere la nostra rivista sempre pi\uf9 incisiva nel mondo della reumatologia. Questi sono stati suggeriti e discussi con i due codirettori Roberto Caporali e Piercarlo Sarzi-Puttini: sapere che loro facevano parte del team ha reso di molto pi\uf9 facile la decisione di accettare questo incarico, del quale sono, ovviamente, onorato. Il momento \ue8 senza dubbio propizio ed entusiasmante: la reumatologia italiana sta confermando il suo ruolo in Europa (EULAR 2010 a Roma, primato nella partecipazione scientifica dei reumatologi italiani ai congressi europei, pubblicazioni internazionali, presidenze di commissioni, ecc.) e questo non potr\ue0 non avere ricadute anche su Reumatismo

Microbial Agents as Putative Inducers of B Cell Lymphoma in Sjögren's Syndrome through an Impaired Epigenetic Control : The State-of-The-Art

Introduction: Understanding the mechanisms underlying the pathogenesis of Sj\uf6gren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evidence concerning the role that infections or dysbiosis plays in the epigenetic control of gene expression in SS patients and their possible involvement in B cell lymphomagenesis. Materials and Methods: We searched the PubMed and Google Scholar databases and selected a total of 92 articles published during the last 25 years that describe experimental and clinical studies of the potential associations of microbiota and epigenetic aberrations with the risk of B cell lymphoma in SS patients. Results and Discussion: The genetic background of SS patients is characterized by the hyperexpression of genes that are mainly involved in regulating the innate and adaptive immune responses and oncogenesis. In addition, salivary gland epithelial cells and lymphocytes both have an altered epigenetic background that enhances the activation of proinflammatory and survival pathways. Dysbiosis or chronic latent infections may tune the immune response and modify the cell epigenetic machinery in such a way as to give B lymphocytes an activated or transformed phenotype. It is also worth noting that transposable integrated retroelements may participate in the pathogenesis of SS and B cell lymphomagenesis by inducing DNA breaks, modulating cell gene expression, or generating aberrant transcripts that chronically stimulate the immune system. Conclusions: Microorganisms may epigenetically modify target cells and induce their transcriptome to generate an activated or transformed phenotype. The occurrence of lymphoma in more than 15% of SS patients may be the end result of a combination of genetics, epigenetics, and dysbiosis or latent infections