Scheduling and Batching in Multi-Site Flexible Flow Shop Environments

Global competition and the customers demand for customized products with shorter due dates, marked the introduction of the Extended Enterprise. In this Extended Manufacturing Environment (EME), lean, virtual, networked and distributed enterprises collaborate to respond to the market demands. In this paper we study the influence of the batch size on Flexible Flow Shop makespan minimization problem FFC vertical bar vertical bar C-max for two multi-sites approaches, the FSBF (Flow Shop Based Factories) and the PMBF (Parallel-Machines Based Factories). The computational study demonstrates how the performance of the PMBF model decreases with the increase of batch size and determines the batch sizes in which the performance is similar.This work is supported by FEDER Funds through the “Programa Operacional Factores de Competitividade - COMPETE” program and by National Funds through FCT “Fundação para a Ciência e a Tecnologia” under the projects: “Projeto Estratégico–UI 252–2011–2012” reference PEstOE/EME/UI0252/2014, FCOMP-01-0124-FEDER-PEstOE/EEI/UI0760/2014.info:eu-repo/semantics/publishedVersio

Evaluation of Management Routes for the Paldiski Sarcophagi

The necessity to develop the submarine fleet in Russia required constructing a special training base for the training of submarine crews. To this purpose two prototypes of nuclear power units, close analogous to those fitting out nuclear submarines were constructed and commissioned in the sixties on the Navy training centre's base located in Paldiski (Pakri peninsula, Estonia). In 1994, nuclear fuel was discharged from the reactors and transported to Russia while the reactors themselves were prepared for prolonged storage, prior to transfer of the Paldiski facilities to the ownership of the Estonian Republic. The Paldiski facilities are currently being dismantled with the exception of two sarcophagi made of concrete that are housing the two reactor compartments. The question of the future management of both sarcophagi is a key-issue in the cleaning up of the whole Paldiski site. Actually, three basic questions should answered: when should dismantling operations occur, how this should be done, and what could be the corresponding cost. Within the context of enlargement of the European Union, the Commission services (first Directorate-General for Environment and then Directorate-General for Enlargement) decided to support Estonia to respond to these three questions through a study contract that was awarded in 1999 to a TECHNICATOME/BNFL consortium. The work scope was made up of three distinct tasks: data collection regarding the nuclear reactors and enclosing compartments design, and the works carried in order to prepare the reactor compartments for long-term storage; drawing up dismantling strategies in order to reach the third decommissioning level defined by IAEA; and evaluation of these decommissioning options on the basis cost estimation and radiological impact evaluation, in view to recommend the best management route. This article gives the key stages and the conclusions of this study

Foundations of attention sharing: orienting and responding to attention in term and preterm 5-month-old infants

Attention is the gateway to perceptual, cognitive, and socioemotional development in humans. We observed 104 5-month-old term and preterm infants and their mothers in social interactions to address three questions about the role of maturation in orienting and responding to attention. We used a fine-grained coding system to allow parallel comparisons across infant and maternal orienting, and sequential analysis to evaluate infant and maternal responding to attention. Orienting and responding to attention differed for attention to people versus objects, as did the relations between maturity and attention. We conclude that maturity contributes to orienting and responding to attention and that orienting and responding to attention are specific rather than homogenous. We discuss the implications of these conclusions for future studies of how attention influences cognitive and communicative development

Virtual Enterprise integration management based on a Meta-enterprise - A PMBoK approach

A Virtual Enterprise (VE) can be viewed as a project, with a lifecycle corresponding to the period between its creation and integration of the constituting elements until its dissolution, comprehending its operation and including its reconfigurations. The authors propose that the VE lifecycle is aligned and can be managed using the frameworks provided by several bodies of knowledge, such as the PMBoK Guide. In this paper the authors propose an alignment referential between the Project Management phases defined by PMBoK and management processes during the VE lifecycle.This work has been supported by (1) COMPETE: POCI-01-0145-FEDER-007043 (2) FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2013.info:eu-repo/semantics/publishedVersio

Manual de procedimentos de referência e pesquisa dos serviços de atendimento da Biblioteca Acadêmico Luiz Viana Filho, do Senado Federal

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Ciência da Informação, Curso de Graduação em Biblioteconomia, 2018.O objetivo deste trabalho é elaborar/atualizar o Manual dos processos realizados pela área de Atendimento ao Usuário, pertencente a Biblioteca Acadêmico Luiz Viana Filho do Senado Federal, que engloba os setores de Serviço de Empréstimo e Devolução de Material Bibliográfico (SEEMP), Serviço de Pesquisa e Recuperação de Informações Bibliográficas (SEPRIB), Serviço de Manutenção e Conservação de Acervo (SEMACO) e o Serviço de Pesquisa Parlamentar (SEPESP). O manual proporciona o registro das atividades realizadas diariamente, pelos setores mencionados, direcionadas para senadores, servidores do senado e usuários externos que são seu público alvo. Fez-se necessário a descrição de rotinas, para a orientação de como funcionam os processos, tanto para os servidores que os realizam, quanto para os futuros funcionários da instituição, além de servir como base para melhorias nos serviços prestados pelo setor. Para a coleta de dados foram utilizados a pesquisa participante, a análise documental e entrevista com profissionais dos setores. Utiliza como procedimentos metodológicos a abordagem qualitativa descritiva e a pesquisa participante.The objective of this work is to prepare a Manual of the processes performed by the Customer Service area, belonging to the Luiz Viana Filho Academic Library of the Federal Senate, which encompasses the Service of Loan and Return of Bibliographic Material (SEEMP), Research and Recovery of Bibliographic Information (SEPRIB), Service of Maintenance and Preservation of the Collection (SEMACO) and the Service of Parliamentary Research (SEPESP). The purpose of the manual is to provide a record of activities performed daily by the sectors mentioned above, directed at senators, senate servers and external users who are your target audience. It was necessary to describe routines, to guide how the processes work, both for the servers that perform them and for the future employees of the institution, as well as serve as a basis for improvements in the services provided by the sector. To collect data were used the participant research, the documentary analysis and interview with professionals of the sectors. It uses as methodological procedures the qualitative descriptive approach and the participant research

Genetic diversity of sugar beet under heat stress and deficit irrigation

In the light of climate changes and globalwarming, as well as the rapid expansion in sugar beet (Beta vulgaris L.) cultivation in Egypt, the development of sugar beet varieties with improved tolerance to high temperature and deficit irrigation is of great importance. The objective of this studywas to evaluate sugar beet genotypes under high temperatures and deficit irrigation conditions for further identification and selection of heat and drought tolerant genotypes. In the current study, a panel of 18 sugar beet breeding lines produced at the USDA–ARS–NWISRL, Kimberly, ID, and the commercial sugar beet cultivar Kawimera were evaluated for yield and quality under high temperature. Six promising lines in terms of yield and quality were further evaluated under both high temperature and deficit irrigation for two growing seasons. All lines performed differently under deficit irrigation, indicating a high degree of genetic variability in the evaluated lines. Additionally, yield traits showed negative effect due to deficit irrigation. A significant positive correlation was observed between stress tolerance index (STI), and average root and sugar yields under stressed and non-stressed conditions. A linear relationship between STI and average root and sugar yields indicates that STI is a reliable stress index to select high yielding genotypes under both optimum- and deficit-irrigation conditions. USKPS25 and USC944-6-68 breeding lines are most likely adapted to deficit irrigation and high temperature and suitable to be utilized in the proposed sugar beet breeding programs in Egypt

Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury

<p>Abstract</p> <p>Background</p> <p>Toll like receptors (TLRs) signaling pathways, including the adaptor protein Mal encoded by the TIRAP gene, play a central role in the development of acute lung injury (ALI). Recently, the <it>TIRAP </it>variants have been described association with susceptibility to inflammatory diseases. The aim of this study was to investigate whether genetic variants in <it>TIRAP </it>are associated with the development of ALI.</p> <p>Methods</p> <p>A case-control collection from Han Chinese of 298 healthy subjects, 278 sepsis-associated ALI and 288 sepsis alone patients were included. Three tag single nucleotide polymorphisms (SNPs) of the TIRAP gene and two additional SNPs that have previously showed association with susceptibility to other inflammatory diseases were genotyped by direct sequencing. The differences of allele, genotype and haplotype frequencies were evaluated between three groups.</p> <p>Results</p> <p>The minor allele frequencies of both rs595209 and rs8177375 were significantly increased in ALI patients compared with both healthy subjects (odds ratio (OR) = 1.47, 95% confidence interval (CI):1.15-1.88, P = 0.0027 and OR = 1.97, 95% CI: (1.38-2.80), P = 0.0001, respectively) and sepsis alone patients (OR = 1.44, 95% CI: 1.12-1.85, P = 0.0041 and OR = 1.82, 95% CI: 1.28-2.57, P = 0.00079, respectively). Haplotype consisting of these two associated SNPs strengthened the association with ALI susceptibility. The frequency of haplotype AG (rs595209A, rs8177375G) in the ALI samples was significantly higher than that in the healthy control group (OR = 2.13, 95% CI: 1.46-3.09, P = 0.00006) and the sepsis alone group (OR = 2.24, 95% CI: 1.52-3.29, P = 0.00003). Carriers of the haplotype CA (rs595209C, rs8177375A) had a lower risk for ALI compared with healthy control group (OR = 0.69, 95% CI: 0.54-0.88, P = 0.0003) and sepsis alone group (OR = 0.71, 95% CI: 0.55-0.91, P = 0.0006). These associations remained significant after adjustment for covariates in multiple logistic regression analysis and for multiple comparisons.</p> <p>Conclusions</p> <p>These results indicated that genetic variants in the TIRAP gene might be associated with susceptibility to sepsis-associated ALI in Han Chinese population. However, the association needs to be replicated in independent studies.</p

Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor β on mRNA stability and translatability

Estrogen signaling is mediated by estrogen receptors (ERs), ERα and ERβ. Aberrant estrogen signaling is involved in breast cancer development. ERα is one of the key biomarkers for diagnosis and treatment of breast cancer. Unlike ERα, ERβ is still not introduced as a marker for diagnosis and established as a target of therapy. Numerous studies suggest antiproliferative effects of ERβ, however its role remains to be fully explored. Albeit important, ERα is not a perfect marker, and some aspects of ERα function are still unclear. This thesis aims to characterize distinct molecular facets of ER action relevant for breast cancer and provide valuable information for ER-based diagnosis and treatment design. In PAPER I, we analyzed the functionality of two common single nucleotide polymorphisms in the 3’ untranslated regions of ERβ, rs4986938 and rs928554, which have been extensively investigated for association with various diseases. A significant difference in allelic expression was observed for rs4986938 in breast tumor samples from heterozygous individuals. However, no difference in mRNA stability or translatability between the alleles was observed. In PAPER II, we provided a more comprehensive understanding of ERβ function independent of ERα. A global gene expression analysis in a HEK293/ERβ cell model identified a set of ERβ-regulated genes. Gene Ontology (GO) analysis showed that they are involved in cell-cell signaling, morphogenesis and cell proliferation. Moreover, ERβ expression resulted in a significant decrease in cell proliferation. In PAPER III, using the human breast cancer MCF-7/ERβ cell model, we demonstrated, for the first time, the binding of ERα/β heterodimers to various DNA-binding regions in intact chromatin. In PAPER IV, we investigated a potential cross-talk between estrogen signaling and DNA methylation by identifying their common target genes in MCF-7 cells. Gene expression profiling identified around 150 genes regulated by both 17β- estradiol (E2) and a hypomethylating agent 5-aza-2’-deoxycytidine. Based on GO analysis, CpG island prediction analysis and previously reported ER binding regions, we selected six genes for further analysis. We identified BTG3 and FHL2 as direct target genes of both pathways. However, our data did not support a direct molecular interplay of mediators of estrogen and epigenetic signaling at promoters of regulated genes. In PAPER V, we further explored the interactions between estrogen signaling and DNA methylation, with focus on DNA methyltransferases (DNMT1, DNMT3a and DNMT3b). E2, via ERα, up-regulated DNMT1 and down-regulated DNMT3a and DNMT3b mRNA expression. Furthermore, DNMT3b interacted with ERα. siRNA-mediated DNMT3b depletion increased the expression of two genes, CDKN1A and FHL2. We proposed that the molecular mechanism underlying regulation of FHL2 and CDKN1A gene expression involves interplay of DNMT3b and ERα. In conclusion, the studies presented in this thesis contribute to the knowledge of ERβ function, and give additional insight into the cross-talk mechanisms underlying ERα signaling with ERβ and with DNA methylation pathways

Tallinn Radiocarbon Dates VII

This material was digitized as part of a cooperative project between Radiocarbon and the University of Arizona Libraries.The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202