Local Structures of Glassy Al under Various Pressures: A Molecular Dynamics Study

Al materials are used in the wide range of application, such as sporting goods, engine components, and aerospace parts. The rapid solidification of Al can save energy and production cost. It has been known that the properties of materials highly depend on their atomic structure. However, there is lack of structural investigation of the Al solidification under various pressures. In this research, we carried out molecular dynamics simulation to investigate the pressure effect on the formation of glassy Al from the rapid solidification process. The embedded-atom-method potential is used to describe the interatomic interaction between Al atoms. Our calculated melting point is in reasonable agreement with the experimental result, confirming the capability of the embedded-atom-method potential for use in the high-temperature simulations. From our molecular dynamics simulation of rapid solidification process, it is obvious that the high pressure shrinks the size of the supercell. We also find that the population of local structures, i.e. face-centered cubic, body-centered cubic, and icosahedral cluster, increase at higher pressure except for hexagonal close-packed cluster. The population of hexagonal close-packed local structure in the glassy Al decreases by the increasing of pressure

Aktivitas Inhibisi Ekstrak Rambut Jagung (Zea mays Corn Silk) terhadap Angiotensin-I Converting Enzyme

Angiotensin-I Converting Enzyme (ACE) berperan penting dalam patofisiologi hipertensi. Penghambatan ACE telah terbukti sebagai strategi yang efektif sebagai pencegahan dan terapi hipertensi. Indonesia merupakan negara tropis dengan potensi yang tinggi untuk menyediakan tanaman obat. Salah satu tanaman obat yang biasa digunakan sebagai obat antihipertensi adalah jagung, digunakan bagian rambutnya. Pada penelitian ini, dipilih rambut jagung (Zea mays Corn Silk), RJ, untuk dilihat aktivitasnya dalam menghambat kinerja ACE. Sampel diekstrak menggunakan ethanol 80%. pH diukur menggunakan pH indicator. Ekstrak dari tanaman obat ini kemudian diuji aktivitasnya terhadap penghambatan ACE menggunakan KIT-WST DOJINDO. Dalam penelitian ini ditemukan bahwa inhibition rate RJ pada konsentrasi 25ppm; 50 ppm; 100ppm; 200ppm; 400ppm adalah berturut-turut 8,04; 15,55; 23,01; 37,97; 61,15; dengan IC50 307,65 ppm. Hal ini membuktikan bahwa ekstrak RJ dapat dijadikan sumber bahan obat ACE-inhibitor namun masih tergolong memiliki aktivitas yang lemah dibandingkan dengan kontrol (captopril). Kata Kunci: Ekstrak Tanaman Obat, Antihipertensi, Angiotensin-I Converting Enzyme

PENGETAHUAN SISWI TENTANG PERSONAL HYGIENE GENETALIA SAAT MENSTRUASI DI MADRASAH ALIYAH DARUL HUDA

Latar Belakang : Personal hygiene merupakan tindakan untuk memelihara kebersihan atau kesehatan seseorang untuk kesejahteraan fisik maupun psikis. Upaya untuk menuju reproduksi yang sehat harus dimulai saat remaja. Untuk menjaga kebersihan perlu melakukan personal hygiene saat menstruasi dengan benar, karena jika tidak benar akan meningkatkan resiko terkena infeksi pada organ reproduksi. Pemberian intervensi pendidikan perlu dilaksanakan karena intervensi pemberian pendidikan kesehatan menunjukkan hasil yang efektif terhadap peningkatan kesadaran terhadap kontrol penyakit dan mendukung perilaku mencari pelayanan kesehatan. Tujuan : Mengetahui perbedaan pengetahuan siswi tentang personal hygiene genetalia sebelum dan sesudah diberikan pendidikan kesehatan melalui media booklet Metode : Desain penelitian menggunakan kuasi ekperimen dengan rancangan One Group Pretest and Posttest Design. Populasi penelitian adalah seluruh siswi yang bermukim di pondok pesantren Darul Huda sebanyak 361 siswi dan 35 responden terpilih dengan teknik sampling purposive sampling. Pengumpulan data menggunakan kuesioner dan analisa data menggunakan uji non parametrik Wilcoxon Signed Rank test Hasil : siswi yang memiliki pengetahuan baik meningkat dari 28 siswi (80%) menjadi 35 siswi (100%) dengan nilai p sebesar 0,08. Kesimpulan : Tidak terdapat perbedaan bermakna pengetahuan sebelum dan setelah diberikan pendidikan kesehatan melalui media booklet Kata Kunci: booklet; mentruasi; pendidikan kesehatan; pondok pesantren; sisw

Alteration of Splicing Pattern on Angiotensin Converting Enzyme Gene Due To The Insertion of Alu elements

Angiotensin Converting Enzyme (ACE) is a zinc metallopeptidase that has a significant role in blood pressure regulation and the pathophysiology of hypertension. ACE has two protein domains, the N-domain and the C-domain, which each has a single active site that functions independently of each other. There is insertion/deletion by 288 bp Alu elements in the intron 16 of ACE gene. The Alu elements potentially alter splicing process. The effect of the insertion of Alu elements in the splicing pattern of the ACE gene has not been reported. Here, we report on the results of splicing pattern analysis of the ACE gene due to the insertion of Alu elements. Using an in-silico approach, we found the presence of Alu elements insertion in intron 16 of ACE caused alternative splicing and experienced exonization. Further analysis showed that the exonization lead to a premature termination codon (PTC), which is raised protein shortening and lost one of its two protein domains. The loss of one protein domain may affect the catalytic activity of ACE. These findings suggest that the Alu elements I/D polymorphism is related to the differences in the catalytic activity of ACE that may influence blood pressure regulation and hypertension

HUBUNGAN PENGETAHUAN IBU DENGAN POLA ASUH ANAK TEMPER TANTRUM PADA USIA TODDLERDI POSYANDU BALITA DESA GROGOL KECAMATAN SAWOO PONOROGO

Abstract Problems that often occur at the age of toddlers or age 1 – 3 years is temper tantrum, temper tantrum is an inability to control emotions associated with a decrease in emotions towards frustration. One factor of the cause of temper tantrum is parenting pattern . The purpose of this research is to investigate the relationship between knowledge of mother with temper tantrum parenting pattern at age of toddlers at posyandu balita Grogol village Sawoo Ponorogo district.The research design used cross sectional research design. The sampling technique used purpossive sampling, with samples amounted 43 respondents. Data collection tools were questionnaires. Technique collecting data using Fisher’s Exact Test with the helped computer.The results showed that 27 respondents (62.8%) Had good knowledge, 16 respondents (37.2%) Had poor knowledge, 29 respondents (67.4%) Had appropriate parenting, 14 respondents (32.6%) had inappropriate parenting. The statistical test results obtained p value (0.000) < α (0.05) which means there was ,relationship between knowledge of mother’s with parenting of temper tantrum at the age of toddler. With the closeness of the relationship 0.670 which means strong closeness.Referred to the research, it was advisable for subsequent researchers to follow up on this research with the title family conduct against temper tantrum prevention in toddler (age 1 – 3 years old). Abstrak Masalah yang sering timbul pasa saat usiatoddler atau usia 1 – 3 tahun adalah temper tantrum, temper tantrum merupakan ketidakmampuan untuk mengontrol emosi yang berkaitan dengan penurunan emosi terhadap frustrasi. Salah satu faktor penyebab terjadinya temper tantrum adalah pola asuh orang tua. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan ibu dengan pola asuh anak temper tantrum pada usiatoddler di Posyandu Balita Desa Grogol Kecamatan Sawoo Ponorogo. Desain penelitian yang digunakan adalah desain penelitian cross sectional. Tekhnik sampling yang digunakan adalah purpossive sampling, dengan sampel berjumlah 43 responden.Alat pengumpulan data yaitu kuesioner.Tekhnik pengumpulan data menggunakan uji Fisher’s Exact Test dengan bantuan komputer. Hasil penelitian didapatkan bahwa 27 responden (62,8%) memiliki pengetahuan yang baik, 16 responden (37,2%) memiliki pengetahuan yang buruk, 29 responden (67,4%) memiliki pola asuh yang sesuai, 14 responden (32,6%) memiliki pola asuh yang tidak sesuai. Hasil uji statistik diperoleh p value (0,000) < α (0,05) yang berarti ada hubungan pengetahuan ibu dengan pola asuh anak temper tantrum pada usia toddler.Dengan keeratan hubungan 0,670 yang berarti keeratan kuat.Mengacu pada penelitian, disarankan bagi peneliti selanjutnya untuk menindaklanjuti penelitian ini dengan judul Perilaku keluarga terhadap pencegahan temper tantrum pada anak usiatoddler (usia 1 – 3 tahun)

PERBEDAAN EFEKTIVITAS PEMBERIAN AIR REBUSAN DAUN ALPUKAT DAN DAUN SELEDRI TERHADAP PENURUNAN TEKANAN DARAH PADA LANSIA HIPERTENSI

Hypertension is a condition where there is an increase in systolic pressure of more than 140 mmHg and diastolic pressure of more than 90 mmHg. The elderly have a high risk of suffering from high blood pressure. There are therapies that are often used for people with hypertension, including the therapy of boiled avocado or celery leaves. The purpose of this test is to test the effectiveness of avocado or celery leaf decoction therapy in lowering blood pressure in the elderly with hypertension. This research uses Quasi Experiment and Pretest Posttest Control Group Design. The sampling stage is purposive sampling, where in this study with a sample of 16 people and will be divided into two groups, with 8 people in avocado leaf stew and the remaining 8 people in celery stew. The results of the study using the Paired T test showed that the difference in mean systole and diastole after being given boiled avocado leaves was 15.25 and 11.7, while the difference in mean systole and diastole after being given boiled celery was 11.4 and 10.95. While the results of the Independent T test of the comparison of the intervention and control groups obtained a systolic p-value = 0.015 (<0.05) and a diastolic p-value = 0.001 (<0.05), which means that there is an effectiveness of avocado or celery leaf decoction therapy in lowering blood pressure in elderly with hypertension. Based on this study, avocado leaves and celery both can lower blood pressure in the elderly with hypertension, but the results show that avocado leaf decoction is proven to be more effective in lowering blood pressure than celery. With these results, it is hoped that it can be used as a reference for therapy for the elderly with hypertension other than drugs

EFEKTIFITAS PENYULUHAN SEKS BEBAS MENGGUNAKAN VIDEO DAN GAMBAR TERHADAP PENGETAHUAN SEKS BEBAS PADA REMAJA

Abstract Counseling is done to improve the knowledge of respondents. Counseling using video media has a real picture and liked the target. This study aims to determine the effectiveness of counseling using video and images of free sex knowledge in adolescents. The research method used quasi experimental design with Pretest-posttest control design design in this study there are two groups selected by simple random sampling. The population in this study is students of class XI In Vocational High School 1 Nawangan country Nawangan which amounted to 178 person. The overall sample in this study were 54 respondents, for each treatment group 27 respondents. The data were processed using computter program with paired T-Test to see the significance difference between pretest-postest of each counseling medium and Independent T-test to see the effectiveness between video and image media, significance level (p) ≤ 0.05. The result of the research shows the counseling using video media with the highest value of pretest 75, average 60,65. Posttest the highest value of 100 averages 81.02. Counseling using image media pretest value score highest score 87,5 on average 60,19. While the highest posttest value of 93.75 averaged 70.14. Pursuant to result of independent T-test obtained p value = 0,005, which mean p value smaller than α = 0,05. So there is a significant difference between video and image media extension.The conclusion of this research is counseling using video media more effective than image media in increasing free sex knowledge in adolescent. It is expected to increase the knowledge of free sex in adolescent In Vocational High School 1 Nawangan country Nawangan institutions using video as a media counseling

Hubungan Mengonsumsi Makanan Cepat Saji (Fast Food) dengan Kejadian Dismenore Pada Remaja Putri di SMP N 1 Ponorogo

Angka kejadian dismenore didunia sangat besar. Lebih 50% perempuan disetiap Negara mengalami nyeri menstruasi. Di Amerika sebesar 60%,dan di Swedia 72%, sementara di Indonesia angka kejadian dismenore sebesar 64.25%. dismenore primer disebabkan oleh diet atau pola makan makanan cepat saji. Penelitian ini bertujuan untuk mengetahui hubungan menggonsumsi makanan cepat saji (fast food) dengan kejadian dismenore di SMPN 1 Ponorogo.desain penelitian iniadalah korelasi dengan jumlah populasi 170 orang. tehnik sampling menggunakan purposive sampling dengan sampel 63 responden. Pengumpulan data menggunakan kuisioner MSQ (Menstrual Symtom Questionnaire) dan  untuk frekuensi makanan cepat saji menggunakan FFQ (Food Frequency Questionnaire). Uji statistic Chi-Square dengan taraf signifikasi <0.05.dari hasil penelitian terhadap 63 responden terdapat 35 responden (55.6%) sering mengonsumsi fast food dengan kejadian dismenore 27 responden (42.9%) dan 8 responden (12.7%) tidak dismenore, sedangkan 28 responden (44.4%) jarang mengonsumsi fast food didapatkan 14 responden (22.2%) dismenore dan 14 responden (22.2%) tidak dismenore. Hasil uji-chi square diperoleh nilai p value 0.025 (p < 0.05), maka H1 diterima dan H0 ditolak yang berarti ada hubunganmengonsumsi makanan cepat saji dengan kejadian dismenore , dengan keeratan contigency coefficient 0.272

Pengaruh Kompres Kayu Manis (Cinnamomum Burmanii) terhadap Penurunan Nyeri Sendi pada Lansia

Video Pengaruh Kompres Kayu Manis (Cinnamomum Burmanii) terhadap Penurunan Nyeri Sendi pada Lansi

In silico analysis of antihypertensive and hepatotoxicity potential of the n-butanol fraction of the methanol extract of of cantaloupe (Cucumis melo var. cantalupensis)

Abstract Background: Hypertension is a major cardiovascular disease risk factor. Indonesian people tend to consume herbal medicine to maintain hypertension therapy, i.e cantaloupe (Cucumis melo var. cantalupensis). However, the mechanism of action of cantaloupe in lowering blood pressure and toxicity potential for long term consumption is unclear. The study aimed to analyze the antihypertensive mechanism of cantaloupe and its toxic potential through the in silico. Methods: The dried cantaloupe powder was macerated using absolute methanol, then fractionated using n-butanol. The phytochemical test was done by LC-MS method, then the bioactive compounds were traced to their SMILES in the PubChem. The QSAR analysis of the antihypertensive potential was done using the PASS server. The toxicity class and hepatotoxicity potential were analyzed using ProTox-II, followed by networking analysis using STITCH and STRINGdb. Results: At least 434 types of compounds were shown in the n-butanol fraction of the methanol extract of cantaloupe (BFMEC). Based on the networking analysis, BFMEC may work in lowering blood pressure through the action mechanism of the amlodipine compound-like, which stabilizes voltage-gated L-type calcium channels in an inactive conformation, thus, prevents calcium-dependent myocyte contraction and vasoconstriction. BFMEC presumably has hepatotoxic through the action mechanism of itraconazole compound-like inhibited cytochrome P450-dependent enzymes, affecting the impairment of ergosterol synthesis, and efavirenz which has neurotoxic effects. The inhibition of cytochrome P450 may cause drug toxicity and liver damage. Conclusion: BFMEC may work in lowering blood pressure through the action mechanism which stabilizes voltage-gated L-type calcium channels in an inactive conformation