65 research outputs found
Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study
Background
COVID-19 may predispose to both venous and arterial thromboembolism event (TEE).
Reports on the prevalence and prognosis of thrombotic complications are still emerging.
Objective
To describe the rate of TEE complications and its influence in the prognosis of hospitalized
patients with COVID-19 after a cross-sectional study.
Methods
We evaluated the prevalence of TEE and its relationship with in-hospital death among hospitalized patients with COVID-19 who were admitted between 1st March to 20th April 2020
in a multicentric network of sixteen Hospitals in Spain. TEE was defined by the occurrence
of venous thromboembolism (VTE), acute ischemic stroke (AIS), systemic arterial embolism
or myocardial infarction (MI).
Results
We studied 1737 patients with proven COVID-19 infection of whom 276 died (15.9%). TEE
were presented in 64 (3.7%) patients: 49 (76.6%) patients had a VTE, 8 (12.5%) patients
had MI, 6 (9.4%%) patients had AIS, and one (1.5%) patient a thrombosis of portal vein.
TEE patients exhibited a diffuse profile: older, high levels of D-dimer protein and a tendency
of lower levels of prothrombin. The multivariate regression models, confirmed the association between in-hospital death and age (odds ratio [OR] 1.12 [95% CI 1.10–1.14], p<0.001),
diabetes (OR 1.49 [95% CI 1.04–2.13], p = 0.029), chronic obstructive pulmonary disease
(OR 1.61 [95% CI 1.03–2.53], p = 0.039), ICU care (OR 9.39 [95% CI 5.69–15.51],
p<0.001), and TTE (OR 2.24 [95% CI 1.17–4.29], p = 0.015). Conclusions
Special attention is needed among hospitalized COVID-19 patients with TTE and other
comorbidities as they have an increased risk of in-hospital death.We thank HM Hospitales for making their data publicly available as part of the COVID Data Save Lives project
Assessing the Real-Time Informational Content of Macroeconomic Data Releases for Now-/Forecasting GDP: Evidence for Switzerland
This study utilizes the dynamic factor model of Giannone et al. (2008) in order to make now-/forecasts of GDP quarter-on-quarter growth rates in Switzerland. It also assesses the informational content of macroeconomic data releases for forecasting of the Swiss GDP. We find that the factor model offers a substantial improvement in forecast accuracy of GDP growth rates compared to a benchmark naive constant-growth model at all forecast horizons and at all data vintages. The largest forecast accuracy is achieved when GDP nowcasts for an actual quarter are made about three months ahead of the official data release. We also document that both business tendency surveys as well as stock market indices possess the largest informational content for GDP forecasting although their ranking depends on the underlying transformation of monthly indicators from which the common factors are extracted.Business tendency surveys, Forecasting, Nowcasting, Real-time data, Dynamic factor model
Editorial: Remote Ischemic Conditioning (Pre, Per, and Post) as an Emerging Strategy of Neuroprotection in Ischemic Stroke
EDITORIAL articleThis study was funded by Carlos III Health Institute and cofunded by European Union (ERDF A way to make Europe) Project (PI17-01725) and the RICORS Research Network to FP, NIH Funding (R01 NS099455, 1UO1NS113356, and R01 NS112511) to DH, Italian Ministry of Health - PRIN 2017CY3J3W to SB. French National Minsitry of Health Grant 2014 AOR13032 to FP, TE is the Chief Investigator for the Remote ischaemic conditioning after stroke trial (RECAST), RECAST-2, and RECAST-3 funded through the NIHR Efficacy and Mechanism Evaluation (EME) Programme, Award ID NIHR128240
The neuronal ischemic tolerance is conditioned by the Tp53 Arg72Pro polymorphism
Cerebral preconditioning (PC) confers endogenous brain protection after stroke. Ischemic stroke patients with a prior transient
ischemic attack (TIA) may potentially be in a preconditioned state. Although PC has been associated with the activation of prosurvival
signals, the mechanism by which preconditioning confers neuroprotection is not yet fully clarified. Recently, we have
described that PC-mediated neuroprotection against ischemic insult is promoted by p53 destabilization, which is mediated by its
main regulatorMDM2. Moreover, we have previously described that the human Tp53 Arg72Pro single nucleotide polymorphism
(SNP) controls susceptibility to ischemia-induced neuronal apoptosis and governs the functional outcome of patients after stroke.
Here, we studied the contribution of the human Tp53 Arg72Pro SNP on PC-induced neuroprotection after ischemia. Our results
showed that cortical neurons expressing the Pro72-p53 variant exhibited higher PC-mediated neuroprotection as compared with
Arg72-p53 neurons. PC prevented ischemia-induced nuclear and cytosolic p53 stabilization in Pro72-p53 neurons. However, PC
failed to prevent mitochondrial p53 stabilization, which occurs in Arg72-p53 neurons after ischemia. Furthermore, PC promoted
neuroprotection against ischemia by controlling the p53/active caspase-3 pathway in Pro72-p53, but not in Arg72-p53 neurons.
Finally, we found that good prognosis associated to TIA within 1 month prior to ischemic stroke was restricted to patients
harboring the Pro72 allele. Our findings demonstrate that the Tp53 Arg72Pro SNP controls PC-promoted neuroprotection against
a subsequent ischemic insult bymodulatingmitochondrial p53 stabilization and then modulates TIA-induced ischemic tolerance.This work was funded by The Instituto de Salud Carlos III grants CP14/00010 (M.D.-E.); PI15/00473 and RD12/0014/ 0007 (A.A.); CM14/00096 (ME.R.-A.); RD16/0019/0018 (C.R.); and Junta de Castilla y Leon grant BIO/SA35/15 (M.D.-E.), and the European Regional Development Fund (R.V.) was funded by the FPU program (Ministerio de Educación)
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