Hybrid Approach for Resource Allocation in Cloud Infrastructure Using Random Forest and Genetic Algorithm

In cloud computing, the virtualization technique is a significant technology to optimize the power consumption of the cloud data center. In this generation, most of the services are moving to the cloud resulting in increased load on data centers. As a result, the size of the data center grows and hence there is more energy consumption. To resolve this issue, an efficient optimization algorithm is required for resource allocation. In this work, a hybrid approach for virtual machine allocation based on genetic algorithm (GA) and the random forest (RF) is proposed which belongs to a class of supervised machine learning techniques. The aim of the work is to minimize power consumption while maintaining better load balance among available resources and maximizing resource utilization. The proposed model used a genetic algorithm to generate a training dataset for the random forest model and further get a trained model. The real-time workload traces from PlanetLab are used to evaluate the approach. The results showed that the proposed GA-RF model improves energy consumption, execution time, and resource utilization of the data center and hosts as compared to the existing models. The work used power consumption, execution time, resource utilization, average start time, and average finish time as performance metrics

Unusual Renal Tumors — Report of Four Cases

Collecting duct carcinoma, plasmocytoma and malignant fibrous histocytoma are rare but aggressive tumors of the kidneys. We present four cases we have recently encountered in our practice. In most of the cases imaging did not help in the pre-operative diagnosis. Surgery is the mainstay of treatment when recognized early. Clinician should be aware about these rare varieties of renal tumors whose prognoses may be worse than that of renal cell carcinoma. The Annals of African Surgery, Volume 6, 201

Intelligent Fault-Tolerant Mechanism for Data Centers of Cloud Infrastructure

Fault tolerance in cloud computing is considered as one of the most vital issues to deliver reliable services. Checkpoint/restart is one of the methods used to enhance the reliability of the cloud services. However, many existing methods do not focus on virtual machine (VM) failure that occurs due to the higher response time of a node, byzantine fault, and performance fault, and existing methods also ignore the optimization during the recovery phase. This paper proposes a checkpoint/restart mechanism to enhance reliability of cloud services. Our work is threefold: (1) we design an algorithm to identify virtual machine failure due to several faults; (2) an algorithm to optimize the checkpoint interval time is designed; (3) lastly, the asynchronous checkpoint/restart with log-based recovery mechanism is used to restart the failed tasks. The valuation results obtained using a real-time dataset shows that the proposed model reduces power consumption and improves the performance with a better fault tolerance solution compared to the nonoptimization method

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Not AvailableTofu or soybean curd is mainly made by coagulating soymilk. Tofu whey, a by-product of tofu manufacturing, is currently discarded by the food industry. The Tofu whey refuse is highly perishable and needs a quick treatment for effective utilization. Tofu whey which composition is related to optimum coagulating condition. The different coagulating conditions had great influence on tofu yield, texture, biochemical properties and whey composition. Different coagulants (calcium sulphate, calcium chloride and magnesium chloride and magnesium chloride) were used to optimize the coagulating parameters and optimal concentration of coagulation (OCC) at different temperatures for soymilk coagulation and tofu preparation. Each soymilk batch prepared with coagulants (20 mM to 90 mM) at 600 ,700 ,800 ,900 C. Coagulated batches were pressed to make tofu and measured whey volume, pH, transmittance tofu yield and coagulant efficiency. Whey transmittance and conductance correlated with coagulant concentration. Tofu yield, conductivity, pH and TDS data were also found to depend on coagulating conditions. Conductivity and transmittance could be used to optimize tofu coagulation. The OCC value was found to differ with coagulating conditions.Not Availabl

Synchronous primary cancers of urinary bladder and kidney and prostate

Synchronous occurrence of two or more than two primary cancers of the urinary tract is quite rare, and poses a difficult treatment challenge. Here, we present a case of syn-chronous renal cell carcinoma, transitional cell carcinoma of urinary bladder and adenocarcinoma of prostate diagnosed within a short period. To the best of our knowledge, this is the first case reported from India and the youngest patient reported in the literature having this combination of urinary cancers

Efficacy of Quercetin as a potent sensitizer of β2-AR in combating the impairment of fluid clearance in lungs of rats under hypoxia

•Acute hypoxia exposure (6h) desensitise the the β2 adrenergic receptors (β2 AR) present in the lungs of the rats.•Hypoxia mediated dysregulation of β2 AR resulted into the down regulation of Alveolar fluid clearance (AFC) in the lungs.•Increased production of reative oxygen species (ROS) as a result of hypoxia lead to the aberrant expression of Protein Kinase A (PKA) independent of cAMP levels.•Quercetin exhibited higher binding affinity towards β2 AR over salbutamol.•Prophylactic administration of quercetin resulted in the resensitization of β2 AR cascade and elevated the excess fluid clearance in the lungs. Hypoxia reportedly increases free radical generation in the body, causing oxidative stress and inhibiting β2-AR signaling. The present study correlates the prophylactic potential of quercetin and salbutamol in ameliorating fluid clearing capacity of lungs by re-sensitizing β2-AR signaling under hypoxia. Male SD rats supplemented orally with quercetin (50 mg/Kg BW), and salbutamol (2 mg/Kg BW) were exposed to hypobaric hypoxia at 7620 m for 6 h. Western blotting and ELISA quantitated NFĸB and related genes and GPCR pathway proteins. The binding affinities of drugs with receptor were determined by SPR spectroscopy and further confirmed insilico. Quercetin and salbutamol pre-treatment significantly up-regulated the expressions of β2-AR, GPR-1, GPR-10, GCSα, cAMP content, and down-regulated GRK-2, β-arrestin, ROS, NFκB (p < 0.001), thus, enhancing alveolar fluid clearance (AFC). SPR and insilico findings revealed a higher binding affinity of β2-AR with quercetin over salbutamol. Results indicated quercetin to be a better prophylactic that augmented AFC in rats exposed to hypoxia by attenuating inflammation and stimulating β2-AR

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Not AvailableThe quality parameters of sauerkraut fermented using Lactobacillus paracasei in terms of its lactic acid bacteria count, texture, colour and biochemical properties were studied. As a starter culture L. paracasei grown in tofu whey was used for sauerkraut fermentation. The experiments were planned using central composite rotatable design of response surface methodology for input variables – culture volume (ml), fermentation time (days) and salt concentration (g/100 g). The linear and interactive effect of variables on responses was understood by statistically significant (p<0.01) second-order models. Amongst all the input variables culture volume was found to have an overwhelming effect over all the responses. There was a significant (p<0.01) increase in the lactic acid bacteria count of finished product; it was less hard but there was a departure in colour from the traditional product. The optimized condition for sauerkraut fermentation in terms of culture volume (ml), fermentation time (day) and salt concentration (g/100 g) was 30 ml, 28 days and 1 g/100 g, respectively. It was also observed that phenolics content was better in starter culture sauerkraut over the one traditionally prepared.Not Availabl

Hemodynamic stress response during laparoscopic cholecystectomy: Effect of two different doses of intravenous clonidine premedication

Background : Clonidine has emerged as an attractive premedication desirable in laparoscopic surgery wherein significant hemodynamic stress response is seen. The minimum safe and effective dose of intravenous clonidine to attenuate the hemodynamic stress response during laparoscopic surgery has however not yet been determined. Materials and Methods : This prospective, randomized, double-blind controlled study was conducted on 90 adults of ASA physical status I and II, scheduled for laparoscopic cholecystectomy under general anesthesia. Patients were randomized to one of the three groups (n= 30). Group I received 100 ml of normal saline, while groups II and III received 1 μg/ kg and 2 μg/ kg of clonidine respectively, intravenous, in 100 ml of normal saline along. All patients received glycopyrrolate 0.004 mg/kg and tramadol 1.5 mg/kg intravenously, 30 min before induction. Hemodynamic variables (heart rate, systolic, diastolic, mean arterial pressure), SpO2, and sedation score were recorded at specific timings. MAP above 20% from baseline was considered significant and treated with nitroglycerine. Results : In group I, there was a significant increase in hemodynamic variables during intubation pneumoperitoneum and extubation (P<0.001). Clonidine given 1 μg/kg intravenous attenuated hemodynamic stress response to pneumoperitoneum (P<0.05), but not that associated with intubation and extubation. Clonidine 2 μg/kg intravenous prevented hemodynamic stress response to pneumoperitoneum and that associated with intubation and extubation (P<0.05). As against 14 and 2 patients in groups I and II respectively, no patient required nitroglycerine infusion in group III. Conclusions : Clonidine, 2 μg/ kg intravenously, 30 min before induction is safe and effective in preventing the hemodynamic stress response during laparoscopic cholecystectomy