Health and life quality assessment of patients included in the COVID-19 electronic register

Introduction. COVID-19 infection remains a global medical, economical and societal challenge with clinical and management challenges requiring comprehensive and relevant research. Purpose. Complex assessment of confirmed COVID-19 cases treated in ten medical institutions from Chisinau for the analysis of the health impact of the infection in 2021. Material and methods. The software "Electronic Register of COVID-19 Patients" was developed based on a standardized form. In the register elaboration, the type, quality and scientific value of the information to be collected and stored were taken into account. The collected data included the medical records of COVID-19 patients hospitalized between 1.03.2020 - 30.06.2021. Results. The software was designed with 2 interactive subsystems: the information collection component, implemented in hospital medical institutions and processing component, implemented in USMF „N. Testemitsanu". The egistry included over 8,000 patients with COVID-19, and their number continues to grow. Epidemiological, socio-demographic, clinical, paraclinical data and information on the clinical management of COVID-19 patients are stored securely with different access levels. The created software allows the selection, visualization and statistical analysis of information with generation of different reports according to pre-established or free criteria. Conclusions. The register facilitates research by rapidly processing data on hospitalized COVID-19 patients, is a valuable support for scientific researchers and allows the life quality assessment of the hospitalized patients

Some peculiarities of NPK proportion and contents during ontogenesis in winter wheat

The fact of knowing the peculiarities of the chemical composition of plants is of interest for the diagnosis and interpretation of results in nutritional researches

Soluble glucides accumulation during the tempering of wheat and barley varieties

"Starea de rezistenta la ger" cum o numeste Tumanov (1), adica starea fiziologica a plantelor capabile de calire, se realizeaza prin procese complexe de pregatire pentru iernat, procese care au loc in protoplasma si vacuola celulei. Prin cercetari anterioare s-a dovedit ca la orzul de toamna se dezvolta slab factorii protoplasmatici ai rezistentei; analiza refractometrica a substantei uscate solubile indica o acumulare a acesteia atat la soiurile de grau cat si la cele de orz (2). Datele care se prezinta in aceasta nota aduc completari celor anterioare (2) cu privire la acumularea glucidelor solubile in celulele orzului de toamna prin procesul de calire

Soluble glucides accumulation during the tempering of wheat and barley varieties

"Starea de rezistenta la ger" cum o numeste Tumanov (1), adica starea fiziologica a plantelor capabile de calire, se realizeaza prin procese complexe de pregatire pentru iernat, procese care au loc in protoplasma si vacuola celulei. Prin cercetari anterioare s-a dovedit ca la orzul de toamna se dezvolta slab factorii protoplasmatici ai rezistentei; analiza refractometrica a substantei uscate solubile indica o acumulare a acesteia atat la soiurile de grau cat si la cele de orz (2). Datele care se prezinta in aceasta nota aduc completari celor anterioare (2) cu privire la acumularea glucidelor solubile in celulele orzului de toamna prin procesul de calire

Triazolam is more efficacious than diazepam in a broad spectrum of recombinant GABAA receptors

Benzodiazepine-induced modifications of GABA (γ-aminobutyric acid) activated Cl- currents were studied in native GABAA receptors expressed in neonatal rat brain cortical neurons in primary cultures and in recombinant GABAA receptors expressed in transformed human embryonic kidney cells (293) after a transient transfection with cDNAs encoding for different molecular forms of α, β, and γ subunits of GABAA receptors. The efficacy of triazolam in cortical neurons was higher than that of diazepam. In transfected cells, triazolam showed a greater efficacy as a positive modulator of GABA-elicited Cl- currents in α1β1γ1, α1β1γ2, α1β1γ3, α6β1γ2 and α1β3γ2 receptors than diazepam, except in α3β1γ2 receptors where diazepam was more efficacious. When triazolam and diazepam were applied together to GABAA receptors assembled by transfecting cDNAs encoding for α1β1γ1 subunits, the action of triazolam was curtailed in a manner related to the dose of diazepam. In recombinant receptors assembled with α1β1γ1 receptors, maximally active doses of triazolam were more efficacious than those of clonazepam, alpidem, zolpidem, diazepam or bretazenil. © 1993

Presentación de Casos Clínicos : premolares inferiores supernumerarios retenidos : casos reportados por cursantes de la Carrera de Especialización en Cirugía y Traumatología Bucomaxilofacial de la Facultad de Odontología de la Universidad de Buenos Aires

Fil: VENTURINO, I. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomáxilofacial I; Argentina.Fil: RAMOS, E.A. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomáxilofacial I; Argentina.Fil: PUIA, S.A. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomáxilofacial I; Argentina.Fil: REY, E.A. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomáxilofacial I; Argentina.Se denominan piezas dentarias supernumerarias a aquellas que se forman adicionalmente a la dentición normal. El sitio de presentación más frecuente es el sector anterior del maxilar superior; siendo la zona de los premolares mandibulares la siguiente ubicación de prevalencia de acuerdo al orden de incidencia. Además es esta ubicación la más frecuente en el caso de piezas supernumerarias múltiples no asociadas a síndromes. El tratamiento de elección de estas piezas es el quirúrgico (exodoncia) cuando están retenidas o en malposición, ya que la actitud expectante frente a esta patología puede verse seguido de futuras complicaciones

Estudio del Miedo en Pacientes Frente a la Extracción del Tercer Molar

Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomaxilofacial I. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Psicología. Maestría en Psicología Educacional. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomaxilofacial I. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomaxilofacial I. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Bucomaxilofacial I. Buenos Aires, Argentina

Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.

Positive allosteric modulators of gamma-aminobutyric acid (GABA)A receptors, including benzodiazepines and congeners, can be classified into three categories: 1) full allosteric modulators (i.e., triazolam and alprazolam) that act with high potency and efficacy at many GABAA receptors; 2) selective allosteric modulators (i.e., diazepam) that act with high potency and high efficacy at selected GABAA receptors; and 3) partial allosteric modulators (i.e., bretazenil) that act with high potency but low efficacy at many GABAA receptors. Imidazenil, an imidazobenzodiazepine carboxamide, has been characterized as a novel representative of the partial allosteric modulator class. When tested on a broad spectrum (native and recombinant) of GABAA receptors, imidazenil positively modulates the GABA-elicited Cl- currents with a 4- to 5-fold higher potency but an efficacy (30-50%) lower than that of diazepam, and it antagonizes the effects of the latter drug. Imidazenil in vitro (Ki = 5 x 10(-10) M) and in vivo (ID50 = 0.2 mumol/kg i.v.) displaces [3H]flumazenil from its brain binding sites and in vivo it possesses a marked anticonflict profile in the rat Vogel conflict-punishment test and is 10 times more potent than bretazenil and 100 times more potent than diazepam or alprazolam in antagonizing bicuculline- and pentylenetetrazol-induced seizures. Unlike diazepam and alprazolam, which induce sedation and ataxia and potentiate the effects of ethanol and thiopental at doses similar to those that produce anticonflict effects and occupy 50% of brain flumazenil binding sites, imidazenil does not produce ataxia or sedation in rats nor does it potentiate the effects of ethanol or thiopental in doses 30- to 50-fold higher than those required for the anticonflict effect and for 100% occupancy of brain flumazenil binding sites. Furthermore, when administered with diazepam, imidazenil blocks in a dose-related fashion the sedative, ataxic effects of this drug and thus acts on these unwanted responses as an antagonist (i.e., like flumazenil). In all tests, imidazenil has the pharmacological profile of a partial allosteric modulator, but is more potent than bretazenil, has a longer biological half-life and, in rodents, is virtually unable to cause sedation, ataxia or to potentiate ethanol toxicity