7,138 research outputs found
A case of primary Hodgkin's lymphoma of the parotid gland. Case report and differentian diagnosis from Kuttner's Syndrom
Abstract
We report a rare case of primary Hodgkin’s lymphoma (HL) of the submandibular
gland, with initially diagnosis of Kuttner’s Syndrom. A 48 years old man was referred to our hospital foe evaluation
of a submandibular mass. Although the initial Fine Needle Aspiration and subsequent cytology was highly suggestive for a cronic sialadenitis with lymphoid cells.
After surgical gland removal we obtained a definitive diagnosis of Hodgkin’s lymphoma in
submandibular gland a seat where the most common lymphoma tipe is B
Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease
Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA.Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA
Boosted Cross-Linking and Characterization of High-Performing Self-Assembling Peptides
Tissue engineering (TE) strategies require the design and characterization of novel biomaterials capable of mimicking the physiological microenvironments of the tissues to be regenerated. As such, implantable materials should be biomimetic, nanostructured and with mechanical properties approximating those of the target organ/tissue. Self-assembling peptides (SAPs) are biomimetic nanomaterials that can be readily synthesized and customized to match the requirements of some TE applications, but the weak interactions involved in the self-assembling phenomenon make them soft hydrogels unsuited for the regeneration of medium-to-hard tissues. In this work, we moved significant steps forward in the field of chemical cross-linked SAPs towards the goal of stiff peptidic materials suited for the regeneration of several tissues. Novel SAPs were designed and characterized to boost the 4-(N-Maleimidomethyl) cyclohexane-1-carboxylic acid 3-sulpho-N-hydroxysuccinimide ester (Sulfo-SMCC) mediated cross-linking reaction, where they reached G′ values of ~500 kPa. An additional orthogonal cross-linking was also effective and allowed to top remarkable G′ values of 840 kPa. We demonstrated that cross-linking fastened the pre-existing self-aggregated nanostructures, and at the same time, a strong presence of ß-structures is necessary for an effective cross-linking of (LKLK)3-based SAPs. Combining strong SAP design and orthogonal cross-linking reactions, we brought SAP stiffness closer to the MPa threshold, and as such, we opened the door of the regeneration of skin, muscle and lung to biomimetic SAP technology
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Grid computing technologies for renewable electricity generator monitoring and control
In this paper we discuss the use of real-time Grid computing for the monitoring, control and simulation of renewable electricity generators and their associated electrical networks. We discuss briefly the architectural design of GRIDCC and how we have integrated a number of real (solar, CHP) and simulated conventional power generators into the GRIDCC environment. A local weather station has also been attached to an Instrument Manager to alert experts appropriately when the Solar Array is not generating. The customised remote control and monitoring environment (a virtual control room), distributed using a standard web server, is discussed
Random copying in space
Random copying is a simple model for population dynamics in the absence of
selection, and has been applied to both biological and cultural evolution. In
this work, we investigate the effect that spatial structure has on the
dynamics. We focus in particular on how a measure of the diversity in the
population changes over time. We show that even when the vast majority of a
population's history may be well-described by a spatially-unstructured model,
spatial structure may nevertheless affect the expected level of diversity seen
at a local scale. We demonstrate this phenomenon explicitly by examining the
random copying process on small-world networks, and use our results to comment
on the use of simple random-copying models in an empirical context.Comment: 26 pages, 11 figures. Based on invited talk at AHRC CECD Conference
on "Cultural Evolution in Spatially Structured Populations" at UCL, September
2010. To appear in ACS - Advances in Complex System
Heterogeneous pair approximation for voter models on networks
For models whose evolution takes place on a network it is often necessary to
augment the mean-field approach by considering explicitly the degree dependence
of average quantities (heterogeneous mean-field). Here we introduce the degree
dependence in the pair approximation (heterogeneous pair approximation) for
analyzing voter models on uncorrelated networks. This approach gives an
essentially exact description of the dynamics, correcting some inaccurate
results of previous approaches. The heterogeneous pair approximation introduced
here can be applied in full generality to many other processes on complex
networks.Comment: 6 pages, 6 figures, published versio
Diagnostic value of presepsin for bacterial infection in cirrhosis: a pilot study
Introduction: Presepsin (or sCD14) has been identified as a protein whose levels increase specifically in the blood of patients with bacterial infections. In this study, we evaluated the clinical performance of sCD14 and its usefulness in the early diagnosis of bacterial infection in decompensated cirrhotic patients. Materials: Seventy patients were enrolled in this study. The mean age of patients was 49.5 years, and 21 were women and 49 men. The heparinized whole blood for the PATHFAST test was used in the evaluation of bacterial infection (T0). The test was repeated after 48 hours (T1); at 96 hours (T2); at 144 hours (T3); then at 15 days (T4) to monitor the clinical responses to therapeutic interventions. Results: Forty-nine patients tested positive for sCD14. The mean sCD14 level was 1854 ± 1744 pg/mL. Microbiological findings confirmed the presence of bacterial infections within 84 ± 4.8 h from enrollment in all 49 positive patients. Thirty-eight patients were considered responders to empirical antibiotic therapy with a decrease of presepsin at the different time points, while an increased level of sCD14 was highlighted in 11 patients. When the test was performed, 45% of the patients showed no signs or symptoms of bacterial infection. At 30 days of follow-up 43 patients survived, and 6 patients died from septic shock. Conclusions: The PATHFAST test highlighted the presence of infection in a very short time (15 minutes), and the presepsin could be considered an early biomarker in patients with cirrhosis. A greater number of patients are necessary to confirm these data
Open and / or laparoscopic surgical treatment of liver hydatic cysts
Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period
Agent Based Models of Language Competition: Macroscopic descriptions and Order-Disorder transitions
We investigate the dynamics of two agent based models of language
competition. In the first model, each individual can be in one of two possible
states, either using language or language , while the second model
incorporates a third state XY, representing individuals that use both languages
(bilinguals). We analyze the models on complex networks and two-dimensional
square lattices by analytical and numerical methods, and show that they exhibit
a transition from one-language dominance to language coexistence. We find that
the coexistence of languages is more difficult to maintain in the Bilinguals
model, where the presence of bilinguals in use facilitates the ultimate
dominance of one of the two languages. A stability analysis reveals that the
coexistence is more unlikely to happen in poorly-connected than in fully
connected networks, and that the dominance of only one language is enhanced as
the connectivity decreases. This dominance effect is even stronger in a
two-dimensional space, where domain coarsening tends to drive the system
towards language consensus.Comment: 30 pages, 11 figure
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