Use of the Hedonic Method to Estimate Lake Sedimentation Impacts on Property Values in Mountain Park and Roswell, GA

Metropolitan Atlanta has experienced explosive population growth in the past few decades, which has resulted in rapid residential growth. The City of Roswell is one the best examples of residential growth on the urban fringe of Atlanta, with its housing stock increasing by more than 50 percent from 1990 to 2000. Stormwater runoff created from these development sites is expected to be causing sedimentation accumulation in lakes within Roswell and a neighboring, downstream wildlife refuge located in the City of Mountain Park. Because sedimentation tends to fill-in and shrink lakes, our results provide some indication of the potential property damages associated with sedimentation. Furthermore, our results provide evidence that lake value is not monotonically increasing with lake size, which is believed to be due to the influence that geographic, environmental, and social factors have on the degree to which lakes add value to housing prices.Land Economics/Use,

Developing a weighted model to measure knowledge diffusion in a tourism destination network

Efficient knowledge transfer enhances tourism destination competitiveness. Multiple factors, however, affect knowledge transfer, making it a complex process to quantify. To address this complexity, we developed a quantitative tool by integrating a diffusion model with the major antecedents of knowledge transfer identified in the knowledge management literature. We applied this model in the Western Australian tourism industry and demonstrated its practicality. The proposed model provides a quantitative tool for destination management organizations to monitor, assess and improve the efficiency of knowledge diffusion within their tourism destinations. Such improved knowledge diffusion is critical in strengthening a destination\u27s innovative capabilities and competitiveness

2018: Art & Mobilities Network Inaugural Symposium Instant Journal (Peter Scott Gallery)

"Mobilities has been gaining momentum through networks, conferences, books, special issues, exhibitions and in the practices of artists, writers and curators. In recognition of this activity we are forming an Art & Mobilities network through which to consolidate, celebrate and develop this work.Inspired by the recent foregrounding of Mobility and the Humanities (Pearce & Merriman, 2018) and drawing on last November's successful Mobile Utopia Exhibition amongst others, the Centre for Mobilities Research (CEMORE) at Lancaster University are pleased to hold a UK Art & Mobilities Network Inaugural Symposium 2018 on the 3rd of July 2018. The aim of the symposium is to bring together people in the UK who are active in the field of mobilities and art in order to discuss the distinctive contribution that art makes to mobilities research and vice versa. We would be delighted if you can join us for this one-day event to help shape the network, particularly in the context of a fast-changing world, not just socio-politically but in terms of the place of art in the academy and vice versa. There are nearly 30 key international artists and researchers gathered on this day both locally and via Skype. We invite all participants in the symposium to bring with them an artwork, artefact, written statement or quote that can be displayed as a ‘pop up’ exhibition. These artefacts will be used during the day to focus discussion around different facets of mobilities and art." (Jen Southern, Kai Syng Tan, Emma Rose, Linda O'Keeffe Editors

Prediction of acute myeloid leukaemia risk in healthy individuals

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure(1). The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion(2,3). However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH)(4-8). Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that were obtained on average 6.3 years before AML diagnosis (pre-AML group), together with 414 unselected age- and gender-matched individuals (control group). Pre-AML cases were distinct from controls and had more mutations per sample, higher variant allele frequencies, indicating greater clonal expansion, and showed enrichment of mutations in specific genes. Genetic parameters were used to derive a model that accurately predicted AML-free survival; this model was validated in an independent cohort of 29 pre-AML cases and 262 controls. Because AML is rare, we also developed an AML predictive model using a large electronic health record database that identified individuals at greater risk. Collectively our findings provide proof-of-concept that it is possible to discriminate ARCH from pre-AML many years before malignant transformation. This could in future enable earlier detection and monitoring, and may help to inform intervention