Advanced biohydrogen production using pretreated industrial waste: outlook and prospects

In order to address existing environmental concerns as a result of non-renewable energy sources and to meet future energy demands, biohydrogen offers a suitable alternative energy reserve. Discrete as well as integrative methods of biohydrogen production have been analyzed over time, optimized for achieving high yields. In addition, key process parameters such as temperature, pH, hydraulic retention time, substrate concentration etc., which influence the rate of production have been clarified. Several studies have exploited industrial waste as feed sources for the production of biohydrogen; however, lower yields from these add an additional requirement for suitable pretreatment methods. The present communication examines various pretreatment methods used to increase the accessibility of industrial wastewater/waste for biohydrogen production. Furthermore, a brief overview addresses challenges and constraints in creating a biohydrogen economy. The impacts of pretreating wastes on biohydrogen generation and the latest trends are also supplied. This study helps in the critical understanding of agro-industrial wastes for biohydrogen production, thereby encouraging future outcomes for a sustainable biohydrogen economy

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common

Endocrine disruptors and obesity

The purpose of this review is to summarise current evidence that some environmental chemicals may be able to interfere in endocrine regulation of energy metabolism and adipose tissue structure. Recent findings demonstrate that such endocrine disrupting chemicals, termed “obesogens”, can promote adipogenesis and cause weight gain. This includes compounds to which the human population is exposed in daily life through their use in pesticides/herbicides, industrial and household products, plastics, detergents, flame retardants and ingredients in personal care products. Animal models and epidemiological studies have shown that an especially sensitive time for exposure is in utero or the neonatal period. In summarising the actions of obesogens, it is noteworthy that as their structures are mainly lipophilic, their ability to increase fat deposition has the added consequence of increasing the capacity for their own retention. This has the potential for a vicious spiral not only of increasing obesity but also increasing retention of other lipophilic pollutant chemicals with an even broader range of adverse actions. This might offer an explanation as to why obesity is an underlying risk factor for so many diseases including cancer

Inhibition of cancer cell invasion and metastasis by genistein

Genistein is a small, biologically active flavonoid that is found in high amounts in soy. This important compound possesses a wide variety of biological activities, but it is best known for its ability to inhibit cancer progression. In particular, genistein has emerged as an important inhibitor of cancer metastasis. Consumption of genistein in the diet has been linked to decreased rates of metastatic cancer in a number of population-based studies. Extensive investigations have been performed to determine the molecular mechanisms underlying genistein’s antimetastatic activity, with results indicating that this small molecule has significant inhibitory activity at nearly every step of the metastatic cascade. Reports have demonstrated that, at high concentrations, genistein can inhibit several proteins involved with primary tumor growth and apoptosis, including the cyclin class of cell cycle regulators and the Akt family of proteins. At lower concentrations that are similar to those achieved through dietary consumption, genistein can inhibit the prometastatic processes of cancer cell detachment, migration, and invasion through a variety of mechanisms, including the transforming growth factor (TGF)-β signaling pathway. Several in vitro findings have been corroborated in both in vivo animal studies and in early-phase human clinical trials, demonstrating that genistein can both inhibit human cancer metastasis and also modulate markers of metastatic potential in humans, respectively. Herein, we discuss the variety of mechanisms by which genistein regulates individual steps of the metastatic cascade and highlight the potential of this natural product as a promising therapeutic inhibitor of metastasis

Pancreas divisum and choledochal cyst

Pancreas divisum (PD) is the most common congenital variant of the pancreas, affecting 5% to 14% of the population. The ventral duct only drains the ventral pancreas through the major papilla, whereas the majority of the pancreas drains via the dorsal duct through the minor papilla. We report the case of a 21-year-old woman with recurrent acute pancreatitis who presented with the rare finding of choledochal cyst and pancreas divisum (PD). She underwent minor papilla sphincterotomy and pancreatic duct stenting. Comparable literature findings of PD and choledochal cyst are discussed with regard to the presented case

A rare genetic mutation in a stone former

A 30-year-old woman with history of passage of stones since childhood presented with oliguria and pedal edema for 10 days. She had hypertension with a creatinine of 4.1 mg/dL. Evaluation showed presence of bilateral multiple renal calculi with features of chronicity of kidney disease. Metabolic work-up for nephrolithiasis turned out to be negative and eventually renal biopsy revealed features of chronic interstitial nephritis with greenish brown refractile crystals in the tubular lumen and interstitium. The possibility of dihydroxy adenine crystalline nephropathy was considered. Spectrophotometry of RBC lysates revealed decreased activity of Adenine phosphoribosyl-transferase enzyme. Gene amplification by PCR and sequential analysis identified a missense mutation in exon 3 region of APRT gene in the patient and her family members. This case report highlights the need to contemplate the diagnosis of DHA crystalline nephropathy in young patients with nephrolithiasis and the identification of a rare genetic mutation, which is being reported for the first time in India

Impacts of COVID-19 on Sustainable Development Goals and effective approaches to maneuver them in the post-pandemic environment

In the pursuit of constructing a sustainable world for all through the instrumental seventeen Sustainable Development Goals, the COVID-19 pandemic emerged and affected the efforts concentrated on these goals. Therefore, there is a pressing need to analyze the extent of the impact that unfolded from the pandemic on each Sustainable Development Goal and further to direct the post-pandemic situation to accelerate the progress in every goal. Besides, there exists a knowledge gap in understanding the Sustainable Development Goals and its interaction with each goal through synergic and trade-off effects. To address the aforementioned imperative problems, this study is formulated to perform an impact assessment as well as to provide direction in the post-pandemic environment to effectively progress towards the Sustainable Development Goals by using a hybrid qualitative and quantitative framework. A detailed investigation is carried out to examine the pandemic impacts in every goal, and a quantified impact analysis is performed in terms of the targets of the Sustainable Development Goals with the aid of ranking methodology. The results indicate that SDG 1 and SDG 8 are the most impacted goal. To provide deeper perspectives into the Sustainable Development Goals, a critical analysis of the targets and indicators is performed to characterize the goals from their elemental point of view, such as nature of goals, depending factors, locus of the goal, and Sustainable Development Goal interactions. Further, a novel parameter, the degree of randomness, is proposed whose application in environmental research is immense. The impact on each goal and impact interaction between all the SDGs are also mapped, through which the dynamics of Sustainable Development Goal interactions is elaborated. In context with the post-pandemic scenario, the strategies to achieve the Sustainable Development Goals with environmental focus are presented with prioritization factor that supports quick recovery. The introduced prioritization factor is formulated by employing a multi-criteria analysis methodology. In addition, the fundamental elements of SDGs are built upon one another to frame an optimized and effective approach to achieving the SDGs in the post-pandemic environment. Despite the strategies, a conceptual framework to align the business practices with the SDGs is propounded. This study deep down would provide a unique perspective to the research community and would impart deeper knowledge in connection with sustainability, while the solutions framed would steer the policy and decision-makers