Returning to work following cancer: a qualitative exploratory study into the experience of returning to work following cancer

The experience of returning to work following cancer is a largely unknown area of cancer research. This preliminary study aimed to explore the factors that influence decisions about return to work eitehr during or after cancer treatment and to identify the important aspects of returning to work. Qalitative data were collected using individual interview (n=19) and two focus groups (n=4, n=6), predominantly with breast cancer survivors. Patterns of returning to work were diverse and a variety of reasons influenced work decisions, including financial concerns and regaining normality. Participants also discussed their ability to work, health professionals' advice, side effects, support and adjustments, and attitudes towards work. Although the majority adapted well, a few encountered difficulties on their return. It is evident that more advice is requried from health professionals about returning to work, along with reasonable support and adjustments from employers to ensure that cancer survivors are able to successfully reintegrate back into the workforce

Rhetoric in the language of real estate marketing

“Des. Res.”, “rarely available”, “viewing essential” – these are all part of the peculiar parlance of housing advertisements which contain a heady mix of euphemism, hyperbole and superlative. Of interest is whether the selling agent’s penchant for rhetoric is spatially uniform or whether there are variations across the urban system. We are also interested in how the use of superlatives varies over the market cycle and over the selling season. For example, are estate agents more inclined to use hyperbole when the market is buoyant or when it is flat, and does it matter whether a house is marketed in the summer or winter? This paper attempts to answer these questions by applying textual analysis to a unique dataset of 49,926 records of real estate transactions in the Strathclyde conurbation over the period 1999 to 2006. The analysis opens up a new avenue of research into the use of real estate rhetoric and its interaction with agency behaviour and market dynamics

Non-Newtonian Mechanics

The classical motion of spinning particles can be described without employing Grassmann variables or Clifford algebras, but simply by generalizing the usual spinless theory. We only assume the invariance with respect to the Poincare' group; and only requiring the conservation of the linear and angular momenta we derive the zitterbewegung: namely the decomposition of the 4-velocity in the newtonian constant term p/m and in a non-newtonian time-oscillating spacelike term. Consequently, free classical particles do not obey, in general, the Principle of Inertia. Superluminal motions are also allowed, without violating Special Relativity, provided that the energy-momentum moves along the worldline of the center-of-mass. Moreover, a non-linear, non-constant relation holds between the time durations measured in different reference frames. Newtonian Mechanics is re-obtained as a particular case of the present theory: namely for spinless systems with no zitterbewegung. Introducing a Lagrangian containing also derivatives of the 4-velocity we get a new equation of the motion, actually a generalization of the Newton Law a=F/m. Requiring the rotational symmetry and the reparametrization invariance we derive the classical spin vector and the conserved scalar Hamiltonian, respectively. We derive also the classical Dirac spin and analyze the general solution of the Eulero-Lagrange equation for Dirac particles. The interesting case of spinning systems with zero intrinsic angular momentum is also studied.Comment: LaTeX; 27 page

Interval Subroutine Library Mission

We propose the collection, standardization, and distribution of a full-featured production quality library for reliable scientific computing with routines using interval techniques for use by the wide community of applications developers

Housing prices and multiple employment nodes: is the relationship nonmonotonic?

Standard urban economic theory predicts that house prices will decline with distance from the central business district. Empirical results have been equivocal, however. Disjoints between theory and empirics may be due to a nonmonotonic relationship between house prices and access to employment arising from the negative externalities associated with proximity to multiple centres of employment. Based on data from Glasgow (Scotland), we use gravity-based measures of accessibility estimated using a flexible functional form that allows for nonmonotonicity. The results are thoroughly tested using recent advances in spatial econometrics. We find compelling evidence of a nonmonotonic effect in the accessibility measure and discuss the implications for planning and housing policy

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.PMCID: PMC385649

Post-Newtonian accurate parametric solution to the dynamics of spinning compact binaries in eccentric orbits: The leading order spin-orbit interaction

We derive Keplerian-type parametrization for the solution of post-Newtonian (PN) accurate conservative dynamics of spinning compact binaries moving in eccentric orbits. The PN accurate dynamics that we consider consists of the third post-Newtonian accurate conservative orbital dynamics influenced by the leading order spin effects, namely the leading order spin-orbit interactions. The orbital elements of the representation are explicitly given in terms of the conserved orbital energy, angular momentum and a quantity that characterizes the leading order spin-orbit interactions in Arnowitt, Deser, and Misner-type coordinates. Our parametric solution is applicable in the following two distinct cases: (i) the binary consists of equal mass compact objects, having two arbitrary spins, and (ii) the binary consists of compact objects of arbitrary mass, where only one of them is spinning with an arbitrary spin. As an application of our parametrization, we present gravitational wave polarizations, whose amplitudes are restricted to the leading quadrupolar order, suitable to describe gravitational radiation from spinning compact binaries moving in eccentric orbits. The present parametrization will be required to construct `ready to use' reference templates for gravitational waves from spinning compact binaries in inspiralling eccentric orbits. Our parametric solution for the post-Newtonian accurate conservative dynamics of spinning compact binaries clearly indicates, for the cases considered, the absence of chaos in these systems. Finally, we note that our parametrization provides the first step in deriving a fully second post-Newtonian accurate `timing formula', that may be useful for the radio observations of relativistic binary pulsars like J0737-3039.Comment: 18 pages, accepted by Phys. Rev.

Aspects of electrostatics in a weak gravitational field

Several features of electrostatics of point charged particles in a weak, homogeneous, gravitational field are discussed using the Rindler metric to model the gravitational field. Some previously known results are obtained by simpler and more transparent procedures and are interpreted in an intuitive manner. Specifically: (i) We show that the electrostatic potential of a charge at rest in the Rindler frame is expressible as A_0=(q/l) where l is the affine parameter distance along the null geodesic from the charge to the field point. (ii) We obtain the sum of the electrostatic forces exerted by one charge on another in the Rindler frame and discuss its interpretation. (iii) We show how a purely electrostatic term in the Rindler frame appears as a radiation term in the inertial frame. (In part, this arises because charges at rest in a weak gravitational field possess additional weight due to their electrostatic energy. This weight is proportional to the acceleration and falls inversely with distance -- which are the usual characteristics of a radiation field.) (iv) We also interpret the origin of the radiation reaction term by extending our approach to include a slowly varying acceleration. Many of these results might have possible extensions for the case of electrostatics in an arbitrary static geometry. [Abridged Abstract]Comment: 26 pages; accepted for publication in Gen.Rel.Gra

Laboratory evaluation of molecular xenomonitoring using mosquito excreta/feces to amplify Plasmodium, Brugia, and Trypanosoma DNA

Background: Results from an increasing number of studies suggest that mosquito excreta/feces (E/F) testing has considerable potential to serve as a supplement for traditional molecular xenomonitoring techniques. However, as the catalogue of possible use-cases for this methodology expands, and the list of amenable pathogens grows, a number of fundamental methods-based questions remain. Answering these questions is critical to maximizing the utility of this approach and to facilitating its successful implementation as an effective tool for molecular xenomonitoring. Methods: Utilizing E/F produced by mosquitoes or tsetse flies experimentally exposed to Brugia malayi, Plasmodium falciparum, or Trypanosoma brucei brucei, factors such as limits of detection, throughput of testing, adaptability to use with competent- and incompetent-vector species, and effects of additional blood feedings post parasite-exposure were evaluated. Two platforms for the detection of pathogen signal (quantitative real-time PCR and digital PCR [dPCR]) were also compared, with strengths and weaknesses examined for each. Results: Experimental results indicated that high throughput testing is possible when evaluating mosquito E/F for the presence of either B. malayi or P. falciparum from both competent- and incompetent-vector mosquito species. Furthermore, following exposure to pathogen, providing mosquitoes with a second, uninfected bloodmeal did not expand the temporal window for E/F collection during which pathogen detection was possible. However, this collection window did appear longer in E/F collected from tsetse flies following exposure to T. b. brucei. Testing also suggested that dPCR may facilitate detection through its increased sensitivity. Unfortunately, logistical obstacles will likely make the large-scale use of dPCR impractical for this purpose. Conclusions: By examining many E/F testing variables, expansion of this technology to a field-ready platform has become increasingly feasible. However, translation of this methodology from the lab to the field will first require the completion of field-based pilot studies aimed at assessing the efficacy of E/F screening

Estimating the environmental impact of dairy cattle breeding programs through emission intensity.

A recently developed methodological approach for determining the greenhouse gas emissions impact of national breeding programs was applied to measure the effects of current and future breeding goals on the emission intensity (EI) of the Canadian dairy industry. Emission intensity is the ratio of greenhouse gas outputted in comparison to the product generated. Traits under investigation affected EI by either decreasing the direct emissions yield (i.e. increasing feed performance), changing herd structure (i.e. prolonging herd life) or through the dilution effect of increased production (i.e. increasing fat yield). The intensity value (IV) of each trait, defined as the change in emissions' intensity per unit change in each trait, was calculated for each of the investigated traits. The IV trend of these traits was compared for the current and prospective selection index, as well as for a system with and without quota (the supply management policy designed to prevent overproduction). The overall EI of the average genetic merit Canadian dairy herd per breeding female was 5.07 kg CO2eq/kg protein equivalent output. The annual reduction in EI due to the improvement of production traits was -0.027, -0.018 and -0.006 for fat, protein and milk other solids, respectively. The functional traits, herd life and mastitis resistance, had more modest effects (-0.008 and -0.001, respectively). These results are consistent with international studies that identified traits related to production, survival, health and fertility as having the largest impact on the environmental footprint of dairy cattle. Overall, the dairy industry is becoming more efficient by reducing its EI through selection of environmentally favorable traits, with a 1% annual reduction of EI in Canada