Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits

The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Research report (University of Texas at Austin. Center for Transportation Research)

"In this report the Center of Transportation Research at The University of Texas at Austin undertook a comprehensive research study to identify and determine when, where, and under what circumstances Texas Department of Transportation (TxDOT) should pursue the implementation of Value Extraction Applications (VEA), and how to effectively recognize and involve key stakeholders.

Geochronology of igneous rocks in the Sierra Norte de Córdoba (Argentina): Implications for the Pampean evolution at the western Gondwana margin

U-Pb zircon data (secondary ion mass spectrometry [SIMS] and thermal ionization mass spectrometry [TIMS] analyses) from igneous rocks with differing structural fabrics in the Sierra Norte de Córdoba, western Argentina, suggest that the sedimentary, tectonic, and magmatic history in this part of the Eastern Sierras Pampeanas spans the late Neoproterozoic–Early Cambrian. A deformed metarhyolite layer in metaclastic sedimentary rocks gives a crystallization age of 535 ± 5 Ma, providing a limit on the timing of the onset of D1 deformation and metamorphism. The new data coupled with published Neoproterozoic zircon dates from a rhyolite beneath the metaclastic section and detrital zircon ages from the section indicate a late Neoproterozoic to Early Cambrian depositional age, making this section time equivalent with the Puncoviscana Formation (sensu lato) of northwest Argentina. A synkinematic granite porphyry gives a crystallization age of 534 ± 5 Ma, providing a limit on the age of dextral mylonitization in the Sierra Norte area (D2 event). The new age is consistent with ages of 533 ± 4 Ma from a mylonitic granite with dextral sense-of-shear fabrics and 531 ± 4 Ma from a late-synkinematic dacitic porphyry, which broadly indicates the final age of dextral deformation. A crystallization age of zircons from the postkinematic, high-level El Tío granite (530 ± 4 Ma) suggests that both stages of Pampean deformation and regional metamorphism, accompanied by synkinematic intrusions, were followed by uplift and took place during a very short time span in the Early Cambrian. This is supported by zircon dates of 523 ± 5 Ma from a rhyolite to dacite in the western part of the Rodeito area and dates from the undeformed El Escondido rhyolite and granite of 519 ± 4 Ma and 521 ± 4 Ma, respectively. These three crystallization ages also indicate that ductile dextral shearing and mylonitization associated with the Pampean D2 event terminated in the Early Cambrian. Both stages of Pampean deformation in this segment of the western pre-Andean Gondwana margin seem to represent a continuous event that can be related to oblique dextral convergence between the overriding plate in the east and the subducting and finally colliding plate in the west. The postkinematic intrusions and extrusions are related to the late stage of the Pampean magmatic history, which terminated before Early Ordovician (Famatinian) time.Fil: Von Gosen, W.. Friedrich-Alexander-Universität; AlemaniaFil: McClelland, W. C.. University of Iowa; Estados UnidosFil: Loske, W.. Ludwig-Maximilians-UNiversität München; AlemaniaFil: Martinez, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto Geológico del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Prozzi, Carlos. Universidad Nacional del Sur. Departamento de Geologia. Catedra de Petrologia; Argentin