9 research outputs found
Development, characterisation, and deployment of the SNO+ liquid scintillator
- Author
- Anderson MR
- Andringa S
- Anselmo L
- Arushanova E
- Asahi S
- Askins M
- Auty DJ
- Back AR
- Barnard Z
- Barros N
- Bartlett D
- BarĂŁo F
- Bayes R
- Beier EW
- Berg R Van
- Bialek A
- Biller SD
- Blucher E
- Bonventre R
- Boulay M
- Braid D
- Caden E
- Callaghan EJ
- Caravaca J
- Carvalho J
- Cavalli L
- Chauhan D
- Chen M
- Chkvorets O
- Clark KJ
- Cleveland B
- Collaboration SNO
- Connors C
- Cookman D
- Coulter IT
- Cox MA
- Cressy D
- Dai X
- Darrach C
- Davis-Purcell B
- Deluce C
- Depatie MM
- Descamps F
- Dittmer J
- Duhaime N
- Duncan F
- Dunger J
- Earle AD
- Fabris D
- Falk E
- Farrugia A
- Fatemighomi N
- Fischer V
- Fletcher E
- Ford R
- Frankiewicz K
- Gagnon N
- Gann GD Orebi
- Gaur A
- Gilje K
- González-Reina OI
- Gooding D
- Gorel P
- Graham K
- Grant C
- Grove J
- Grullon S
- Guillian E
- Hall S
- Hallin AL
- Hallman D
- Hans S
- Hartnell J
- Harvey P
- Hedayatipour M
- Heintzelman WJ
- Heise J
- Helmer RL
- Horne D
- Hreljac B
- Hu J
- Hussain ASM
- Iida T
- Inácio AS
- Jackson M
- Jelley NA
- Jillings CJ
- Jones C
- Jones PG
- Kamdin K
- Kaptanoglu T
- Kaspar J
- Keeter K
- Kefelian C
- Khaghani P
- Kippenbrock L
- Klein JR
- Knapik R
- Kofron J
- Kormos LL
- Korte S
- Krar B
- Kraus C
- Krauss CB
- Krosigk B von
- Kroupova T
- Labe K
- Lafleur F
- Lam I
- Lan C
- Land BJ
- Lane R
- Langrock S
- LaTorre A
- Lawson I
- Lebanowski L
- Lefeuvre GM
- Leming EJ
- Li A
- Lidgard J
- Liggins B
- Lin YH
- Liu X
- Liu Y
- Lodovico F Di
- Lozza V
- Luo M
- Maguire S
- Maio A
- Majumdar K
- Manecki S
- Maneira J
- Martin RD
- Marzec E
- Mastbaum A
- Mauel J
- McCauley N
- McDonald AB
- Mekarski P
- Meyer M
- Miller C
- Mills C
- Mlejnek M
- Mony E
- Morton-Blake I
- Mottram MJ
- Nae S
- Nirkko M
- Nolan LJ
- Novikov VM
- O'Keeffe HM
- O'Sullivan E
- Parnell MJ
- Paton J
- Peeters SJM
- Pershing T
- Petriw Z
- Petzoldt J
- Pickard L
- Pracsovics D
- Prior G
- Prouty JC
- Quirk S
- Reichold A
- Riccetto S
- Richardson R
- Rigan M
- Robertson A
- Rose J
- Rosero R
- Rost PM
- Rumleskie J
- Schumaker MA
- Schwendener MH
- Scislowski D
- Secrest J
- Seddighin M
- Segui L
- Seibert S
- Semenec I
- Shaker F
- Shantz T
- Sharma MK
- Shokair TM
- Sibley L
- Sinclair JR
- Singh K
- Skensved P
- Smiley M
- Sonley T
- Stainforth R
- Strait M
- Stringer MI
- Svoboda R
- Sörensen A
- Tam B
- Tatar J
- Tian L
- Tolich N
- Tseng J
- Tseung HWC
- Turner E
- Veinot JGC
- Virtue CJ
- Vázquez-Jáuregui E
- Walker JMG
- Walker M
- Walton SC
- Wang J
- Ward M
- Wasalski O
- Waterfield J
- Weigand JJ
- White RF
- Wilson JR
- Winchester TJ
- Woosaree P
- Wright A
- Yanez JP
- Yeh M
- Zhang T
- Zhang Y
- Zhao T
- Zuber K
- Zummo A
- Publication venue
- Publication date
- 10/05/2021
- Field of study
A liquid scintillator consisting of linear alkylbenzene as the solvent and 2,5-diphenyloxazole as the fluor was developed for the SNO+ experiment. This mixture was chosen as it is compatible with acrylic and has a competitive light yield to pre-existing liquid scintillators while conferring other advantages including longer attenuation lengths, superior safety characteristics, chemical simplicity, ease of handling, and logistical availability. Its properties have been extensively characterized and are presented here. This liquid scintillator is now used in several neutrino physics experiments in addition to SNO+
Three caldera-shaped accidents: Volcanic calderas, meteoric scars and lunar cirques
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The role of outdoor adventure education in facilitating groupwork in higher education
- Author
- A Athiyaman
- A Mutch
- B Mullen
- BA Fletcher
- BC Dart
- CBI
- CBI
- CP Earley
- CS Ferguson
- D Howitt
- D Kolb
- D Prouty
- DL Kirkpatrick
- DW Johnson
- E Pfaff
- E Vlamis
- G Elkin
- H Suri
- I Juriza
- J Burdett
- J Cumming
- J Cumming
- J Desse
- J Dewey
- J Hattie
- J Jostad
- J Krug
- J Mezirow
- J Mezirow
- J Neily
- JC Morey
- Jennifer Cumming
- JL Xie
- JS Prichard
- JS Prichard
- L Porter
- L Praslova
- L Springer
- LH Gillis
- M Branine
- M Prince
- M Tozer
- MA Gass
- MA Gass
- MT Harun
- N Furman
- P Cranton
- P Mazany
- PF Buller
- R Bennett
- R DeLay
- R Rushmer
- RB Winston
- RD Arvey
- RM Homan
- RN Ghulam
- RO Kimball
- S Prince
- Sam J. Cooley
- SJ Cooley
- T Odello
- TD Cook
- V Braun
- V Walsh
- Victoria E. Burns
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The SNO+ experiment
- Author
- :
- Albanese V.
- Alves R.
- Anderson M. R.
- Andringa S.
- Anselmo L.
- Arushanova E.
- Asahi S.
- Askins M.
- Auty D. J.
- Back A. R.
- Back S.
- Barnard Z.
- Barr A.
- Barros N.
- Bartlett D.
- BarĂŁo F.
- Bayes R.
- Beaudoin C.
- Beier E. W.
- Berardi G.
- Bialek A.
- Biller S. D.
- Blucher E.
- Bonventre R.
- Boulay M.
- Braid D.
- Caden E.
- Callaghan E. J.
- Caravaca J.
- Carvalho J.
- Cavalli L.
- Chauhan D.
- Chen M.
- Chkvorets O.
- Clark K. J.
- Cleveland B.
- Collaboration SNO+
- Connors C.
- Cookman D.
- Coulter I. T.
- Cox M. A.
- Cressy D.
- Dai X.
- Darrach C.
- Davis-Purcell B.
- Deluce C.
- Depatie M. M.
- Descamps F.
- Di Lodovico F.
- Dittmer J.
- Doxtator A.
- Duhaime N.
- Duncan F.
- Dunger J.
- Earle A. D.
- Fabris D.
- Falk E.
- Farrugia A.
- Fatemighomi N.
- Felber C.
- Fischer V.
- Fletcher E.
- Ford R.
- Frankiewicz K.
- Gagnon N.
- Gann G. D. Orebi
- Gaur A.
- Gauthier J.
- Gibson-Foster A.
- Gilje K.
- González-Reina O. I.
- Gooding D.
- Gorel P.
- Graham K.
- Grant C.
- Grove J.
- Grullon S.
- Guillian E.
- Hall S.
- Hallin A. L.
- Hallman D.
- Hans S.
- Hartnell J.
- Harvey P.
- Hedayatipour M.
- Heintzelman W. J.
- Heise J.
- Helmer R. L.
- Hodak B.
- Hodak M.
- Hood M.
- Horne D.
- Hreljac B.
- Hu J.
- Hussain A. S. M.
- Iida T.
- Inácio A. S.
- Jackson C. M.
- Jelley N. A.
- Jillings C. J.
- Jones C.
- Jones P. G.
- Kamdin K.
- Kaptanoglu T.
- Kaspar J.
- Keeter K.
- Kefelian C.
- Khaghani P.
- Kippenbrock L.
- Klein J. R.
- Knapik R.
- Kofron J.
- Kormos L. L.
- Korte S.
- Krar B.
- Kraus C.
- Krauss C. B.
- Kroupová T.
- Labe K.
- Lafleur F.
- Lam I.
- Lan C.
- Land B. J.
- Lane R.
- Langrock S.
- Larochelle P.
- Larose S.
- LaTorre A.
- Lawson I.
- Lebanowski L.
- Lefeuvre G. M.
- Leming E. J.
- Li A.
- Li O.
- Lidgard J.
- Liggins B.
- Liimatainen P.
- Lin Y. H.
- Liu X.
- Liu Y.
- Lozza V.
- Luo M.
- Maguire S.
- Maio A.
- Majumdar K.
- Manecki S.
- Maneira J.
- Martin R. D.
- Marzec E.
- Mastbaum A.
- Mathewson A.
- McCauley N.
- McDonald A. B.
- McFarlane K.
- Mekarski P.
- Meyer M.
- Miller C.
- Mills C.
- Mlejnek M.
- Mony E.
- Morissette B.
- Morton-Blake I.
- Mottram M. J.
- Nae S.
- Nirkko M.
- Nolan L. J.
- Novikov V. M.
- O'Keeffe H. M.
- O'Sullivan E.
- Parnell M. J.
- Paton J.
- Peeters S. J. M.
- Pershing T.
- Petriw Z.
- Petzoldt J.
- Pickard L.
- Pracsovics D.
- Prior G.
- Prouty J. C.
- Quirk S.
- Read S.
- Reichold A.
- Riccetto S.
- Richardson R.
- Rigan M.
- Ritchie I.
- Robertson A.
- Robertson B. C.
- Rose J.
- Rosero R.
- Rost P. M.
- Rumleskie J.
- Schumaker M. A.
- Schwendener M. H.
- Scislowski D.
- Secrest J.
- Seddighin M.
- Segui L.
- Seibert S.
- Semenec I.
- Shaker F.
- Shantz T.
- Sharma M. K.
- Shokair T. M.
- Sibley L.
- Sinclair J. R.
- Singh K.
- Skensved P.
- Smiley M.
- Sonley T.
- St-Amant M.
- Stainforth R.
- Stankiewicz S.
- Strait M.
- Stringer M. I.
- Stripay A.
- Svoboda R.
- Sörensen A.
- Tacchino S.
- Tam B.
- Tanguay C.
- Tatar J.
- Tian L.
- Tolich N.
- Tseng J.
- Tseung H. W. C.
- Turner E.
- Van Berg R.
- Veinot J. G. C.
- Virtue C. J.
- von Krosigk B.
- Vázquez-Jáuregui E.
- Walker J. M. G.
- Walker M.
- Wallig J.
- Walton S. C.
- Wang J.
- Ward M.
- Wasalski O.
- Waterfield J.
- Weigand J. J.
- White R. F.
- Wilson J. R.
- Winchester T. J.
- Woosaree P.
- Wright A.
- Yanez J. P.
- Yeh M.
- Zhang T.
- Zhang Y.
- Zhao T.
- Zuber K.
- Zummo A.
- Publication venue
- 'IOP Publishing'
- Publication date
- 23/07/2021
- Field of study
The SNO+ experiment is located 2 km underground at SNOLAB in Sudbury, Canada. A low background search for neutrinoless double beta (0) decay will be conducted using 780 tonnes of liquid scintillator loaded with 3.9 tonnes of natural tellurium, corresponding to 1.3 tonnes of [130]Te. This paper provides a general overview of the SNO+ experiment, including detector design, construction of process plants, commissioning efforts, electronics upgrades, data acquisition systems, and calibration techniques. The SNO+ collaboration is reusing the acrylic vessel, PMT array, and electronics of the SNO detector, having made a number of experimental upgrades and essential adaptations for use with the liquid scintillator. With low backgrounds and a low energy threshold, the SNO+ collaboration will also pursue a rich physics program beyond the search for 0 decay, including studies of geo- and reactor antineutrinos, supernova and solar neutrinos, and exotic physics such as the search for invisible nucleon decay. The SNO+ approach to the search for 0 decay is scalable: a future phase with high [130]Te-loading is envisioned to probe an effective Majorana mass in the inverted mass ordering region
Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio)
- Author
- A Ahmed
- A Kapopoulou
- A Mahmood
- A O'Garra
- A Rosser
- A Roy
- A Untergasser
- AM van der Sar
- AM van der Sar
- BD Kana
- BD Kana
- BM Kagina
- BM Tiwari
- CE 3rd Barry
- CJ Cambier
- CL Lancioni
- D Houben
- DM Langenau
- DM Tobin
- DM Tobin
- DR Velez
- E Gasteiger
- Eleanor Sherwood
- F Riano
- F Spertini
- FJ Roca
- G Lugo-Villarino
- GV Mukamolova
- H Clay
- H Li
- H Malen
- H McWilliam
- H Myllymaki
- H Myllymaki
- HA Fletcher
- HE Volkman
- Henna Myllymäki
- HG Choi
- I Comas
- I Schiller
- J Tang
- JD Ernst
- JM Lew
- K Brunner
- Kaisa Ester Oksanen
- KE Oksanen
- KE Oksanen
- KE van Meijgaarden
- KJ Downing
- KJ Livak
- KN Adams
- KN Adams
- L Ramakrishnan
- LD Jasenosky
- LE Swaim
- M Dara
- M Parikka
- M Romano
- M van der Vaart
- MA Liu
- Maarit Ahava
- Mataleena Parikka
- MG Prouty
- Mika Rämet
- Mirja Niskanen
- MJ Brennan
- MJ Ojanen
- MM Hammaren
- MM Serra-Vidal
- O Lohi
- P Andersen
- P Glaziou
- P Kadam
- Pere-Joan Cardona
- Q Xin
- RD Berg
- RK Gupta
- S Commandeur
- S Moller
- S Yoon
- SA Renshaw
- SH Kaufmann
- SH Oehlers
- SK Hatzios
- TP Stinear
- V Torraca
- V Wittamer
- VV Yeremeev
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The Evolution of Literature on United States Intelligence
- Author
- Agee Philip
- Agee Philip
- Alsop Stewart
- Baldwin Hanson W.
- Barron John
- Berman Jerry
- Blackstock Paul W.
- Blackstock Paul W.
- Blackstock Paul W.
- Borosage Robert
- Buckley William F.
- Burnham James
- Burnham James
- Cave-Brown Anthony
- Cave-Brown Anthony
- Cline Ray S.
- Copeland Miles
- Copeland Miles
- Copeland Miles
- Copeland Miles
- Corson William R.
- David H. Hunter
- Dulles Allen
- Dziak John J.
- Fain Tyrus G.
- Glass Robert R.
- Goudsmit Samuel A.
- Graham Daniel O.
- Graham Daniel O.
- Halperin Morton H.
- Harris William R.
- Hersh Seymour M.
- Hilsman Roger C.
- Ind. Allison
- Jefferys-Jones Rhodri
- Kahn David
- Kent Sherman
- Kirkpatrick Lyman B. Jr.
- Kirkpatrick Lyman B. Jr.
- Kirkpatrick Lyman B. Jr.
- Klass Phillip J.
- Laird Melvin R.
- Lasby Clarence G.
- Latham Aaron
- MacCloskey Monro
- Marchetti Victor
- McCone John A.
- McGarvey Patrick J.
- Pash Boris T.
- Penkovskiy Oleg
- Pettee George S.
- Phillips David Atlee
- Phillips David Atlee
- Platt Washington
- Possony Stefan T.
- Pratt Fletcher
- Prouty L. Fletcher
- Ransom Harry Howe
- Ransom Harry Howe
- Ransom Harry Howe
- Roosevelt Kermit
- Rositzke Harry
- Rowan Richard W.
- Rowan Richard W.
- Rushford Gregory C.
- Schwien Edwin E.
- Smith Joseph B.
- Stevenson William
- Street Harry
- Taylor John W. R.
- Townsend Elias Carter
- Tully Andrew
- U.S. Commission on CIA Activities Within the United States ("Rockefeller Commission")
- U.S. Commission on the Organization of the Government for the Conduct of Foreign Policy ("Murphy Commission")
- U.S. Congress House
- U.S. Congress House
- U.S. Congress Senate
- U.S. Congress Senate
- U.S. Congress Senate
- Winterbotham F. W.
- Wise David
- Wise David
- Wriston Henry M.
- Yardley Herbert O.
- Zacharias Ellis M.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
- Bajcsi É
- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
- Banks K
- Bansal M
- Baraona F
- Barber C
- Barber C
- Barbir M
- Barillas O
- Barnes D
- Barnett O
- Barr C
- Barrett J
- Barringhaus K
- Barron M
- Bartels GL
- Basilio E
- Bass M
- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
- Battikadi S
- Battin D
- Bauer B
- Baumanns S
- Bautista J
- Bayat J
- Bayer M
- Bayer M
- Bayles A
- Bazzi A
- Beaudry M
- Bedoya R
- Been M
- Belicova M
- Bell K
- Belle L
- Beloscar J
- Beltran R
- Beltrano MC
- Ben-Aharon J
- Ben-Yehuda O
- Benetar J
- Bengtsson PO
- Bennermo M
- Bennett J
- Benyahya L
- Beresford P
- Berezniakov I
- Berger M
- Berger-Kucza A
- Bergeron J
- Berglund M
- Berglund R
- Bergsten J
- Berk M
- Berli M
- Bernardi D
- Berra F
- Berrospi P
- Bertolet B
- Bescos L
- Bethea C
- Bethencourt A
- Betti I
- Betzu R
- Bhalla H
- Bhalodkar N
- Bhargava M
- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
- Birkemeyer R
- Birnbaum Y
- Bishop A
- Bishop B
- Bishop C
- Bissett J
- Bissett J
- Bittel B
- Bitzer V
- Bjornstad H
- Blacher MG
- Blais D
- Blank E
- Blazing M
- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
- Bobek M
- Bocconcelli P
- Bocconcelli P
- Bodanese L
- Bodenstein W
- Boehm S
- Bogomolny N
- Bohle D
- Bohlscheid V
- Bohorquez R
- Bohula Erin A.
- Boliek W
- Bolli R
- Bolsman C
- Bonatti S
- Bondi L
- Bondio M
- Bone C
- Bonnet J
- Bono J
- Book K
- Boomer L
- Boos C
- Botero R
- Bottzauw J
- Botwin S
- Boudriot E
- Bouvier JM
- Bowden W
- Bozek B
- Bradford L
- Bradford L
- Brady A
- Brady A
- Brady A
- Braga J
- Branca G
- Branny M
- Branzi A
- Braun P
- Braunwald Eugene
- Breen J
- Brike C
- Britto F
- Britto F
- Britto F
- Broadwater S
- Bronnum-Schou J
- Brossoit R
- Brown C
- Brown C
- Brown C
- Brown J
- Brunelli C
- Brunelli C
- Brunk S
- Bruno N
- Brunvand H
- Brussee H
- Bryniarski L
- Budzon S
- Bueno M
- Buerke M
- Buerke M
- Bugos V
- Buijs EM
- Buijs F
- Bullivant M
- Burgess L
- Burghard S
- Burley T
- Burton J
- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- CalderĂłn MJ
- Calic S
- Califf
- Calpar I
- Calzolari D
- Campbell C
- Campbell T
- Campos C
- Cannon C
- Cannon C
- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
- Capucci A
- Cardillo MT
- Cardinal F
- Cardoso A
- Carell E
- Carell E
- Carey C
- Carlessi C
- Carlevaro O
- Carling-Chambers L
- Carlsson F
- Carmelo M
- Carr K
- Carrageta M
- Carrageta M
- Carrageta M
- Carrié D
- Carswell BS
- Cartasegna L
- Caruso O
- Casalins M
- Casares G
- Caso P
- Caspi A
- Cassadonte F
- Cassavar D
- Cassel G
- Castoldi M
- Castro P
- Castro R
- Catarino C
- Caussin C
- Cauthren T
- Cavallini C
- Ceder-Brolin K
- Centeno E
- Centurion C
- Cepeda M
- Cequier A
- Chadwyn D
- Chae SC
- Chalavarya G
- Chambers J
- Chandler G
- Chandna H
- Chandna H
- Chandna H
- Chandra P
- Chandraratna P
- Chandrasekaran S
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- Zanolin D
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- Zweiker R
- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit