19 research outputs found
History of malaria treatment as a predictor of subsequent subclinical parasitaemia: A cross-sectional survey and malaria case records from three villages in Pailin, western Cambodia
Background: Treatment of the sub-clinical reservoir of malaria, which may maintain transmission, could be an important component of elimination strategies. The reliable detection of asymptomatic infections with low levels of parasitaemia requires high-volume quantitative polymerase chain reaction (uPCR), which is impractical to conduct on a large scale. It is unknown to what extent sub-clinical parasitaemias originate from recent or older clinical episodes. This study explored the association between clinical history of malaria and subsequent sub-clinical parasitaemia. Methods: In June 2013 a cross-sectional survey was conducted in three villages in Pailin, western Cambodia. Demographic and epidemiological data and blood samples were collected. Blood was tested for malaria by high-volume qP
History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross-sectional survey and malaria case records from three villages in Pailin, western Cambodia
Background
Treatment of the sub-clinical reservoir of malaria, which may maintain transmission, could be an important component of elimination strategies. The reliable detection of asymptomatic infections with low levels of parasitaemia requires high-volume quantitative polymerase chain reaction (uPCR), which is impractical to conduct on a large scale. It is unknown to what extent sub-clinical parasitaemias originate from recent or older clinical episodes. This study explored the association between clinical history of malaria and subsequent sub-clinical parasitaemia.
Methods
In June 2013 a cross-sectional survey was conducted in three villages in Pailin, western Cambodia. Demographic and epidemiological data and blood samples were collected. Blood was tested for malaria by high-volume qPCR. Positive samples were analysed by nested PCR to determine the Plasmodium species. To identify previous episodes of malaria, case records were collected from village malaria workers and local health facilities and linked to study participants.
Results
Among 1343 participants, 40/122 (32.8 %) with a history of clinical malaria were parasitaemic during the cross-sectional survey, compared to 172/1221 (14.1 %) without this history (p
Conclusions
A clinical episode of vivax malaria was associated with subsequent sub-clinical parasitaemia. Treatment of P. vivax with artemisinin-based combination therapy without primaquine often resulted in recurrent episodes. Targeting individuals with a history of clinical malaria will be insufficient to eliminate the sub-clinical reservoir as they constitute a minority of parasitaemias.</p
Erratum: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: A randomized, controlled trial in Lao PDR (Malaria Journal (2020) 19 (4) DOI: 10.1186/s12936-019-3091-5)
Following publication of the original article [1], it was brought to the authors' attention that one of the names in the author list had been provided with the incorrect spelling. Namely, Mehul Dhorda had been incorrectly spelled as Mehul Dorda. The error has since been corrected in the original article. The authors apologize for any inconvenience caused
MOESM4 of Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study
Additional file 4. Additional figures. Geographic distribution of k13 mutations in two study sites and study enrollment screening during study period
Journees d'etudes, la metrologie de l'exposition sonore en milieu indusrtriel Recueil des resumes, communications et debats
Available at INIST (FR), Document Supply Service, under shelf-number : 18477, issue : a.1991 n.84 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc
Scatterplot and linear prediction for the association between parasitaemia and plasma CRP concentrations.
<p>Scatterplot and linear prediction for the association between parasitaemia and plasma CRP concentrations.</p
Distribution of CRP concentrations in both sets of controls, cases, and in cases with vivax and falciparum mono-infections.
<p>Distribution of CRP concentrations in both sets of controls, cases, and in cases with vivax and falciparum mono-infections.</p
Demographic data for same person controls, age- sex- village matched controls and cases, and those for the sub-groups with <i>P</i>.<i>falciparum</i> and <i>P</i>.<i>vivax</i> mono-infections.
<p>Demographic data for same person controls, age- sex- village matched controls and cases, and those for the sub-groups with <i>P</i>.<i>falciparum</i> and <i>P</i>.<i>vivax</i> mono-infections.</p
CRP values and distributions in cases and controls.
<p>CRP values and distributions in cases and controls.</p