Synthèse d'antimétabolites potentiels des bases puriques

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Investigating the molecular mechanism of latrophilin signalling

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Synthèse de la 5‐Amino‐4‐Chloro‐6‐Mercaptopyrimine et de la 7‐Chloro‐Thiazolo [5,4‐d] Pyrimidine

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Synthèse de pyrimidines et de thiazolo[5,4‐d]pyrimidines. II. Analogues de la succinoadénine

Two new analogs (III and VII) of succinoadenine have been synthesized. Starting from 7‐chlorothiazolo[5,4‐d]pyrimidine (I), the first one has been prepared by reaction with diethyl D,L‐aspartate, followed by alkaline hydrolysis. On the other hand, direct amination of 7‐methylthiothiazolo[5,4‐d]pyrimidine (IV) with D,L‐aspartic acid has given a product formulated as 5‐formamido‐4‐mercapto‐6‐methylthiopyrimidine (V). An authentic specimen has been prepared for comparison by formylation of 5‐amino‐4‐chloro‐6‐methylthiopyrimidine (VIII) and replacement of the chlorine atom with sodium hydrosulfide. The second analog has been obtained either by reaction of 7‐chlorothiazolo[5,4‐d] pyrimidine (I) with D,L‐mercaptosuccinic acid or by alkylation of 7‐mercapto‐thiazolo[5,4‐d]pyrimidine (VI) with D,L‐bromosuccinic acid. Copyright © 1968 Wiley‐VCH Verlag GmbH & Co. KGaA, WeinheimSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Synthesis of pyrimidines and thiazolo[5,4-d]pyrimidines III. The N.M.R. Spectrum of thiazolo[5,4-d]pyrimidine.

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Further study of the conversion of 5-aminopyrimidines into 4-hydroxypyrimidines via their diazonium salts

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Reactivity and electronic structure of a 4,5-didehydropyrimidine

The reaction of 2-t-butyl-4,5-didehydropyrimidine (2) with 1,3-dienes, two 1,3-dipoles (azides), an electrophile (iodine) and a nucleophile (ethanol) has been investigated. The results are correlated with the electronic structure of 4,5-didehydropyrimidine calculated by an ab initio quantum chemical method. © 1988.SCOPUS: ar.jinfo:eu-repo/semantics/publishe