HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (p for-trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.info:eu-repo/semantics/publishedVersio

Cultura e utilização das plantas medicinais e aromáticas

Este livro divide-se em três capítulos: “A qualidade das plantas medicinais e aromáticas”, “Constituintes activos das plantas medicinais e aromáticas e suas principais acções farmacológicas” e “Fitotecnia das plantas medicinais e aromáticas”. Para além dos capítulos genéricos estão presentes as monografias de 60 taxa, que incluem as mais diversas informações desde características botânicas e ecológicas a aspectos relativos à sua cultura. De forma a auxiliar a leitura foram incluídos dois glossários: um de nomes botânicos e outro de termos médicos. Segundo os autores, “todos os anos a indústria farmacêutica e a de cosmética necessitam de maiores quantidades de plantas medicinais e aromáticas mas com apropriados padrões de qualidade. Este facto tem vindo a proporcionar novas possibilidades à agricultura, existindo em Portugal, como em muitos outros países, uma marcada apetência dos agricultores para a cultura deste tipo de plantas, pois oferecem uma possibilidade de maior rendimento económico em relação à cultura tradicional de plantas

Essential Oil Composition of Eryngium foetidum from S.Tomé e Príncipe

International audienc

Chemical composition of essential oil of Afrocarpus mannii, an endemic species from S. Tomé e Principe

International audienc