Reshaping health services and fuel poverty in the Outer Hebrides

Gluasad Còmhla (Moving Together) started in March 2018 with support or grant from the European Social Fund Aspiring Communities Fund. The project built on the existing practice of Tighean Innse Gall (TIG) and other partners in the Outer Hebrides, to develop an innovative approach to identifying and assisting people whose health is compromised by living in a cold or hard-to-heat home. Over the course of two years, 199 households were assisted through the project. Tighean Innse Gall is a Community Benefit Society working across the Outer Hebrides and operating principally across the housing, community group and small business sectors to support people to access homes and to help to make them comfortable and affordable, promote independent living and encourage businesses and communities to be energy-efficient

Institutional analysis of the regulatory and legal framework for financial reporting control in Russia

The study contains the main approaches to the determination of various institutions affecting Russian accounting from the standpoint of their formal and informal types. In modern conditions, the economic actions of a subject must be matched to external factors that determine the correctness of economic decision-making, as well as consistency and the development of correct patterns and behavior algorithms that are most effective for each specific situation. Through the institutional analysis, the authors have identified several inconsistencies in the regulatory framework of related institutions and suggested ways to eliminate these disparities. Inter-institutional discrepancies have been found between law and accounting institutions, indicating non-compliance in the accounting practice of the substance over form principle, between recognition in the bookkeeping and tax accounting of the transfer of assets and liabilities ownership, as well as differences in the recording of investment real estate in the financial statements according to IFRS institutions and Russian national standards.peer-reviewe

Temozolomide induces senescence but not apoptosis in human melanoma cells

Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O6 position of guanine in DNA. Resistance to the agent may be in part due to the activity of O6-methylguanine-DNA methyl transferase (MGMT). In the present study, we show that sensitivity of melanoma cells to TMZ was dependent on their p53 status and levels of MGMT. Analysis of the mechanisms underlying reduced viability showed no evidence for induction of apoptosis even though marked levels of apoptosis was seen in TK6 lymphoma cells. Sensitivity of melanoma cells was associated with p53-dependent G2/M cell cycle arrest and induction of senescence. To verify the role of p53, the assays were repeated in presence of pifithrin-α, an inhibitor of p53. This resulted in increased viability of melanoma cells with wild-type p53 and reversed G2/M cell cycle arrest. Paradoxically, apoptosis was increased in melanoma but decreased as expected in TK6 lymphoma cells. These results are consistent with the view that TMZ is relatively ineffective against melanoma due to defective apoptotic signalling resulting from activation of p53. The nature of the defects in apoptotic signalling remains to be explored

Suitable Stocking Density Ensures Best Production and Economic Returns in Floating Cage Aquaculture System

The striped dwarf catfish Mystus cavasius being a least concern small indigenous fish it is necessary to protect the species from extinction in the near future. An experiment on production and economic feasibility of Mystus cavasius in cage was conducted for a period of six months from March to August 2020 in beel hilla at Naogaon district of Bangladesh. The study was carried out in nine cages (rectangular 8x5x2 feet size) under three treatments namely T1, T2 and T3 performed with the stocking densities of 46 fry m-2, 92 fry m-2 and 137 fry m-2 and designed each with three replications. The fish was fed with commercial pellet feed (containing 30% crude protein) twice daily at the rate of 5-7% of fish body weight. The total production was found to be significantly (p<0.05) highest in T3 among the three treatments. The net profit was better in T3 than T1 and T2 in terms of better production and money. So, stocking density of Mystus cavasius at the rate of 137 fry m-2 in cage could be an economically feasible aquaculture technique for fish farmers

Notopterygium forbesii Boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: Mechanisms of action

10.1021/tx800301fChemical Research in Toxicology21122414-2423CRTO