87 research outputs found
A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen
Gene expression profiling classifies breast cancer into intrinsic subtypes based on the biology of the underlying disease pathways. We have used material from a prospective randomized trial of tamoxifen versus placebo in premenopausal women with primary breast cancer (NCIC CTG MA.12) to evaluate the prognostic and predictive significance of intrinsic subtypes identified by both the PAM50 gene set and by immunohistochemistry
Basic Atomic Physics
Contains reports on five research projects.National Science Foundation Grant PHY 89-19381National Science Foundation Grant PHY 92-21489U.S. Navy - Office of Naval Research Grant N00014-90-J-1322Joint Services Electronics Program Contract DAAL03-92-C-0001National Science Foundation Grant PHY 89-21769U.S. Army - Office of Scientific Research Grant DAAL03-92-G-0229U.S. Navy - Office of Naval Research Grant N00014-89-J-1207U.S. Navy - Office of Naval Research Grant N00014-90-J-164
Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial
Recent studies suggest that intrinsic breast cancer subtypes may differ in their responsiveness to specific chemotherapy regimens. We examined this hypothesis on NCIC.CTG MA.5, a clinical trial randomizing premenopausal women with node-positive breast cancer to adjuvant CMF (cyclophosphamide-methotrexate-fluorouracil) versus CEF (cyclophosphamide-epirubicin-fluorouracil) chemotherapy
Tracking the emergence of SARS-CoV-2 alpha variant in the United Kingdom
No abstract available
Identification of Candidate Genes for Dyslexia Susceptibility on Chromosome 18
Background: Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage. Here, we set out to identify the gene(s) conferring susceptibility by a two stage strategy of linkage and association analysis. Methodology/Principal Findings: Linkage analysis: 264 UK families and 155 US families each containing at least one child diagnosed with dyslexia were genotyped with a dense set of microsatellite markers on chromosome 18. Association analysis: Using a discovery sample of 187 UK families, nearly 3000 SNPs were genotyped across the chromosome 18 dyslexia susceptibility candidate region. Following association analysis, the top ranking SNPs were then genotyped in the remaining samples. The linkage analysis revealed a broad signal that spans approximately 40 Mb from 18p11.2 to 18q12.2. Following the association analysis and subsequent replication attempts, we observed consistent association with the same SNPs in three genes; melanocortin 5 receptor (MC5R), dymeclin (DYM) and neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L). Conclusions: Along with already published biological evidence, MC5R, DYM and NEDD4L make attractive candidates for dyslexia susceptibility genes. However, further replication and functional studies are still required.Publisher PDFPeer reviewe
Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations
The TESS Grand Unified Hot Jupiter Survey. II. Twenty New Giant Planets
NASA's Transiting Exoplanet Survey Satellite (TESS) mission promises to
improve our understanding of hot Jupiters by providing an all-sky,
magnitude-limited sample of transiting hot Jupiters suitable for population
studies. Assembling such a sample requires confirming hundreds of planet
candidates with additional follow-up observations. Here, we present twenty hot
Jupiters that were detected using TESS data and confirmed to be planets through
photometric, spectroscopic, and imaging observations coordinated by the TESS
Follow-up Observing Program (TFOP). These twenty planets have orbital periods
shorter than 7 days and orbit relatively bright FGK stars ().
Most of the planets are comparable in mass to Jupiter, although there are four
planets with masses less than that of Saturn. TOI-3976 b, the longest period
planet in our sample ( days), may be on a moderately eccentric orbit
(), while observations of the other targets are consistent
with them being on circular orbits. We measured the projected stellar obliquity
of TOI-1937A b, a hot Jupiter on a 22.4 hour orbit with the Rossiter-McLaughlin
effect, finding the planet's orbit to be well-aligned with the stellar spin
axis (). We also investigated the possibility that
TOI-1937 is a member of the NGC 2516 open cluster, but ultimately found the
evidence for cluster membership to be ambiguous. These objects are part of a
larger effort to build a complete sample of hot Jupiters to be used for future
demographic and detailed characterization work.Comment: 67 pages, 11 tables, 13 figures, 2 figure sets. Resubmitted to ApJS
after revision
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK
The physiological effects of vaccination against SARS-CoV-2 (COVID-19) are well documented, yet the behavioural effects not well known. Risk compensation suggests that gains in personal safety, as a result of vaccination, are offset by increases in risky behaviour, such as socialising, commuting and working outside the home. This is potentially important because transmission of SARS-CoV-2 is driven by contacts, which could be amplified by vaccine-related risk compensation. Here, we show that behaviours were overall unrelated to personal vaccination, but—adjusting for variation in mitigation policies—were responsive to the level of vaccination in the wider population: individuals in the UK were risk compensating when rates of vaccination were rising. This effect was observed across four nations of the UK, each of which varied policies autonomously
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