Mjolnir: Extending HAMMER Using a Diffusion Transformation Model and Histogram Equalization for Deformable Image Registration

Image registration is a crucial step in many medical image analysis procedures such as image fusion, surgical planning, segmentation and labeling, and shape comparison in population or longitudinal studies. A new approach to volumetric intersubject deformable image registration is presented. The method, called Mjolnir, is an extension of the highly successful method HAMMER. New image features in order to better localize points of correspondence between the two images are introduced as well as a novel approach to generate a dense displacement field based upon the weighted diffusion of automatically derived feature correspondences. An extensive validation of the algorithm was performed on T1-weighted SPGR MR brain images from the NIREP evaluation database. The results were compared with results generated by HAMMER and are shown to yield significant improvements in cortical alignment as well as reduced computation time

A subjective refraction procedure for intellectually disadvantaged patients

A subjective refraction procedure for intellectually disadvantaged patients plus instructions to parent/teachers

Multibody Modeling and Simulation for the Mars Phoenix Lander Entry, Descent and Landing

A multi-body flight simulation for the Phoenix Mars Lander has been developed that includes high fidelity six degree-of-freedom rigid-body models for the parachute and lander system. The simulation provides attitude and rate history predictions of all bodies throughout the flight, as well as loads on each of the connecting lines. In so doing, a realistic behavior of the descending parachute/lander system dynamics can be simulated that allows assessment of the Phoenix descent performance and identification of potential sensitivities for landing. This simulation provides a complete end-to-end capability of modeling the entire entry, descent, and landing sequence for the mission. Time histories of the parachute and lander aerodynamic angles are presented. The response of the lander system to various wind models and wind shears is shown to be acceptable. Monte Carlo simulation results are also presented

Autonomous three dimensional Newtonian systems which admit Lie and Noether point symmetries

We determine the autonomous three dimensional Newtonian systems which admit Lie point symmetries and the three dimensional autonomous Newtonian Hamiltonian systems, which admit Noether point symmetries. We apply the results in order to determine the two dimensional Hamiltonian dynamical systems which move in a space of constant non-vanishing curvature and are integrable via Noether point symmetries. The derivation of the results is geometric and can be extended naturally to higher dimensions.Comment: Accepted for publication in Journal of Physics A: Math. and Theor.,13 page

Establishment of a model of murine odontoblasts underexpressing Pkd1 using shRNA

We have previously shown that PKD1, the gene encoding Polycystin-1 (or TRPP1) is expressed in human odontoblasts and that this protein is localized at the primary cilium of the cell. Nevertheless, its function remain unclear in this cell even if studies on osteoblasts, osteocytes and chondrocytes give TRPP1 as a promising candidate for mechanotransduction in response to mechanical stress. Consequently, to evaluate the role of TRPP1 in this transduction process, we needed first to generate an in vitro murine model down expressing Pkd1. Using lentivirus-mediated shRNA technology, we obtained a 60% suppression of Pkd1 mRNA expression in transfected MO6-G3 cells associated with a decrease of cell proliferation. Thus, establishment of this murine odontoblast model underexpressing Pkd1 associated with applied mechanical forces (compression or shear stress) will allow us to go further in the determination of TRPP1 involvement in odontoblasts mechanotransduction. Nous avons montré précédemment que PKD1, le gène codant pour la polycystine 1 ou TRPP1, est exprimé dans les cultures d’odontoblastes humains avec une localisation préférentielle de la protéine au niveau des cils primaires. Cependant, la fonction de TRPP1 reste à ce jour inconnue malgré un rôle potentiel de mécanotransducteur mis en évidence dans les ostéoblastes, ostéocytes et chondrocytes. Pour évaluer le rôle de cette protéine dans les odontoblastes nous avons choisi de mettre au point un modèle cellulaire sous-exprimant Pkd1. Ainsi, à l’aide de shRNA, nous avons obtenu une lignée cellulaire de souris (MO6-G3) sous-exprimant de façon stable Pkd1 (60% de sous-expression), et présentant une diminution de la prolifération cellulaire. Ce nouveau modèle cellulaire associé à l’application de forces mécaniques (compression ou étirement) devrait nous permettre d’évaluer l’implication de TRPP1 dans les processus de mécanotransduction des odontoblastes

Energy Resolution Enhancement of Mercuric Iodide Detectors

A pulse processing technique has been developed which improves the gamma-ray energy resolution of mercuric iodide detectors. The technique employs a fast (100 ns) and a slow (6.4 µs) pulse height analysis to correct for signal variations due to variations in charge trapping. The capabilities of the technique for energy resolution enhancement are discussed as well as the utility of the technique for examining the trapping characteristics of individual detectors. We have achieved an energy resolution of 2.6% FWHM at 662 keV with an acceptance efficiency of 100% from a mercuric iodide detector which gives 8.3% FWHM using standard techniques

Entry, Descent, and Landing Operations Analysis for the Mars Phoenix Lander

The Mars Phoenix lander was launched August 4, 2007 and remained in cruise for ten months before landing in the northern plains of Mars in May 2008. The one-month Entry, Descent, and Landing (EDL) operations phase prior to entry consisted of daily analyses, meetings, and decisions necessary to determine if trajectory correction maneuvers and environmental parameter updates to the spacecraft were required. An overview of the Phoenix EDL trajectory simulation and analysis that was performed during the EDL approach and operations phase is described in detail. The evolution of the Monte Carlo statistics and footprint ellipse during the final approach phase is also provided. The EDL operations effort accurately delivered the Phoenix lander to the desired landing region on May 25, 2008

Mars Phoenix Entry, Descent, and Landing Simulation Design and Modelling Analysis

The 2007 Mars Phoenix Lander was launched in August of 2007 on a ten month cruise to reach the northern plains of Mars in May 2008. Its mission continues NASA s pursuit to find evidence of water on Mars. Phoenix carries upon it a slew of science instruments to study soil and ice samples from the northern region of the planet, an area previously undiscovered by robotic landers. In order for these science instruments to be useful, it was necessary for Phoenix to perform a safe entry, descent, and landing (EDL) onto the surface of Mars. The EDL design was defined through simulation and analysis of the various phases of the descent. An overview of the simulation and various models developed to characterize the EDL performance is provided. Monte Carlo statistical analysis was performed to assess the performance and robustness of the Phoenix EDL system and are presented in this paper. Using these simulation and modelling tools throughout the design and into the operations phase, the Mars Phoenix EDL was a success on May 25, 2008

System development and early biological tests in NASA's biomass production chamber

The Biomass Production Chamber at Kennedy Space Center was constructed to conduct large scale plant growth studies for NASA's CELSS program. Over the past four years, physical systems and computer control software have been continually upgraded and the degree of atmospheric leakage from the chamber has decreased from about 40 to 5 percent of the total volume per day. Early tests conducted with a limited degree of closure showed that total crop (wheat) growth from the best trays was within 80 percent of reported optimal yields for similar light levels. Yields from subsequent tests under more tightly closed conditions have not been as good--up to only 65 percent of optimal yields. Yields appear to have decreased with increasing closure, yet potential problems exist in cultural techniques and further studies are warranted. With the ability to tightly seal the chamber, quantitative data were gathered on CO2 and water exchange rates. Results showed that stand photosynthesis and transpiration reached a peak near 25 days after planting, soon after full vegetative ground cover was established. In the final phase of testing when atmospheric closure was the highest, ethylene gas levels in the chamber rose from about 10 to nearly 120 ppb. Evidence suggests that the ethylene originated from the wheat plants themselves and may have caused an epinastic rolling of the leaves, but no apparent detrimental effects on whole plant function

What is taught about dementia in secondary schools? A survey of schools in Sussex, England (innovative practice)

Local dementia education initiatives exist in schools but it is unclear what the wider uptake of such programmes are. A self-created survey was sent to staff in a number of secondary schools (teaching ages 11-16) across Sussex, England. Sixty schools responded to the survey (response rate = 58%). While the majority of schools expressed an interest in including some form of dementia education within their school in the future, only nine schools (15%) currently had dementia education embedded within their curriculum. Despite government calls to reduce stigma and improve attitudes towards dementia, it seems very little is being taught in secondary schools on the topic