The effects of an intensive training and feedback program on investigative interviews of children

In the present study, we assessed the effectiveness of an extensive training and feedback program with investigative interviewers of child victims of alleged abuse and neglect in a large Canadian city. Twelve investigative interviewers participated in a joint training initiative that lasted eight months and involved classroom components and extensive weekly verbal and written feedback. Interviewers were significantly more likely to use open-ended prompts and elicited more information from children with open-ended prompts following training. These differences were especially prominent following a subsequent ‘refresher’ training session. No negative effects of training were observed. Clear evidence was found of the benefits of an intensive training and feedback program across a wide variety of investigative interviews with children. Although previous research has found benefits of training with interviewers of child sexual assault victims, the current study extends these findings to a wide range of allegations and maltreatment contexts

TNT equivalency of M10 propellant

Peak, side-on blast overpressure and scaled, positive impulse have been measured for M10 single-perforated propellant, web size 0.018 inches, using configurations that simulate the handling of bulk material during processing and shipment. Quantities of 11.34, 22.7, 45.4, and 65.8 kg were tested in orthorhombic shipping containers and fiberboard boxes. High explosive equivalency values for each test series were obtained as a function of scaled distance by comparison to known pressure, arrival time and impulse characteristics for hemispherical TNT surface bursts. The equivalencies were found to depend significantly on scaled distance, with higher values of 150-100 percent (pressure) and 350-125 percent (positive impulse) for the extremes within the range from 1.19 to 3.57 m/cube root of kg. Equivalencies as low as 60-140 percent (pressure) and 30-75 percent (positive impulse) were obtained in the range of 7.14 to 15.8 m/cube root of kg. Within experimental error, both peak pressure and positive impulse scaled as a function of charge weight for all quantities tested in the orthorhombic configuration

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements

Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown. We found that cultured neurons from a key forebrain structure, the dorsal thalamus, develop a need for survival factors including brain-derived neurotrophic factor (BDNF) from their major target, the cerebral cortex, at the age at which they innervate it. Experiments in vivo have shown that rates of dorsal thalamic cell death are reduced by increasing cortical levels of BDNF and are increased in mutant mice lacking functional BDNF receptors or thalamocortical projections; these experiments have also shown that an increase in the rates of dorsal thalamic cell death can be achieved by blocking BDNF in the cortex. We suggest that the onset of a requirement for cortex-derived neurotrophic factors initiates a competitive mechanism regulating programmed cell death among dorsal thalamic neurons

Using Spaced Learning Principles to Translate Knowledge into Behavior: Evidence from Investigative Interviews of Alleged Child Abuse Victims

The present study assessed the progress of 13 investigative interviewers (child protection workers and police officers) before, during, and after an intensive training program (n = 132 interviews). Training began with a 2-day workshop covering the principles of child development and child-friendly interviewing. Interviewers then submitted interviews on a bi-weekly basis to which they received written and verbal feedback over an 8-month period. A refresher session took place two months into training. Interestingly, improvements were observed only after the refresher session. Interviews conducted post-refresher training contained proportionally more open-ended questions, more child details in response to open-ended questions, and proportionally fewer closed questions than interviews conducted prior to training and in the first half of the training program. The need for ‘spaced learning’ may underlie why so many training programs have had little effect on practice

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young

In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circadian behavioral rhythms. Over the next 15 years the Hall, Rosbash and Young labs made a series of groundbreaking discoveries that defined the molecular timekeeping mechanism and formed the basis for them being awarded the 2017 Nobel Prize in Physiology or Medicine. Here the authors recount their experiences as post-docs in the Hall, Rosbash and Young labs from the mid-1980s to the mid-1990s, and provide a perspective of how basic research conducted on a simple model system during that era profoundly influenced the direction of the clocks field and established novel approaches that are now standard operating procedure for studying complex behavior

Spitzer Observations of Gamma-Ray Burst Host Galaxies: A Unique Window into High Redshift Chemical Evolution and Star-formation

We present deep Spitzer 3.6 micron observations of three z~5 GRB host galaxies. Our observations reveal that z~5 GRB hosts are a factor of 3 less luminous than the median rest-frame V-band luminosity of spectroscopically confirmed z~5 galaxies in the GOODS fields and the UDF. The strong connection between GRBs and massive star formation implies that not all star-forming galaxies at these redshifts are currently being accounted for in deep surveys and GRBs provide a unique way to measure the contribution to the star-formation rate density from galaxies at the faint end of the galaxy luminosity function. By correlating the co-moving star-formation rate density with co-moving GRB rates at lower redshifts, we estimate a lower limit to the star-formation rate density of 0.12+/-0.09 and 0.09+/-0.05 M_sun/yr/Mpc^3 at z~4.5 and z~6, respectively. Finally, we provide evidence that the average metallicity of star-forming galaxies evolves as (stellar mass density)^(0.69+/-0.17) between $z\sim5$ and $z\sim0$, probably indicative of the loss of a significant fraction of metals to the intergalactic medium, particularly in low-mass galaxies.Comment: ApJ, in pres

A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK

BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c.118G > A in order to estimate the prevalence of the mutation in a referral population of GSD in the UK. RESULTS: This study demonstrated that the RFLP assay, based on use of PCR and subsequent digestion with the Eco571 enzyme, provided a simple genotyping test for the SOD1:c.118G > A mutation. In a young GSD population (i.e. dogs less than 6 years of age, before clinical signs of the disease usually become apparent), 8 of 50 dogs were found to be homozygous and a further 19 were heterozygous for the mutation. In dogs over 8 years of age, 21 of 50 dogs admitted to a tertiary referral hospital with pelvic limb ataxia as a major clinical sign were homozygous for the mutation, compared to none of 50 dogs of similar age, but where no neurological disease was reported on referral. CONCLUSIONS: This data suggests that genotyping for the SOD1:c.118G > A mutation is clinically applicable and that the mutation has a high degree of penetrance. Genotyping might also be useful for screening the GSD population to avoid mating of two carriers, but since the allele frequency is relatively high in the UK population of GSD, care should be taken to avoid reduction in genetic diversity within the breed

Cosmological Implications of the Very High Redshift GRB 050904

We report near simultaneous multi-color (RIYJHK) observations made with the MAGNUM 2m telescope of the gamma ray burst GRB 050904 detected by the SWIFT satellite. The spectral energy distribution shows a very large break between the I and J bands. Using intergalactic transmissions measured from high redshift quasars we show that the observations place a 95% confidence lower limit of z=6.18 on the object, consistent with a later measured spectroscopic redshift of 6.29 obtained by Kawai et al. (2005) with the Subaru telescope. We show that the break strength in the R and I bands is consistent with that measured in the quasars. Finally we consider the implications for the star formation history at high redshift.Comment: Accepted for publication in the Astrophysical Journal. Expanded introduction and discussio

Information behaviour of music record collectors

Introduction: Using Stebbins's concept of 'serious leisure' and Savolainen's concept of 'everyday life information practices', this study explores the information behaviour of music record collectors. Method: An ethnographic approach was used for the study; the main data collection instrument was in-depth, semi-structured interviews with eight record collectors based in and around London, carried out in participants' homes, combined with photographs of their collections and observation of their use of preferred Websites. Analysis: Qualitative analysis was carried out on the survey, with triangulation through conversations with other record collectors, visits to record shops, and examination of some Websites named by participants. Results: The results reveal distinctive information behaviour for record collectors, with specialist knowledge, and a variety of information sources. The Internet has had, and continues to have, a profound effect on both information gathering and acquisition. Conclusions: The study shows that record collectors are exemplars of serious leisure practitioners, with distinct information behaviour. The results add to the knowledge of serious leisure as a topic for study within information science