Technology transfer and other public policy implications of multi-national arrangements for the production of commercial airframes

A study to examine the question of technology transfer through international arrangements for production of commercial transport aircraft is presented. The likelihood of such transfer under various representative conditions was determined and an understanding of the economic motivations for, effects of, joint venture arrangements was developed. Relevant public policy implications were also assessed. Multinational consortia with U.S. participation were focused upon because they generate the full range of pertinent public issues (including especially technology transfer), and also because of recognized trends toward such arrangements. An extensive search and analysis of existing literature to identify the key issues, and in-person interviews with executives of U.S. and European commercial airframe producers was reviewed. Distinctions were drawn among product-embodied, process, and management technologies in terms of their relative possibilities of transfer and the significance of such transfer. Also included are observations on related issues such as the implications of U.S. antitrust policy with respect to the formation of consortia and the competitive viability of the U.S. aircraft manufacturing industry

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young

In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circadian behavioral rhythms. Over the next 15 years the Hall, Rosbash and Young labs made a series of groundbreaking discoveries that defined the molecular timekeeping mechanism and formed the basis for them being awarded the 2017 Nobel Prize in Physiology or Medicine. Here the authors recount their experiences as post-docs in the Hall, Rosbash and Young labs from the mid-1980s to the mid-1990s, and provide a perspective of how basic research conducted on a simple model system during that era profoundly influenced the direction of the clocks field and established novel approaches that are now standard operating procedure for studying complex behavior

Integrating visual and tactile information in the perirhinal cortex

By virtue of its widespread afferent projections, perirhinal cortex is thought to bind polymodal information into abstract object-level representations. Consistent with this proposal, deficits in cross-modal integration have been reported after perirhinal lesions in nonhuman primates. It is therefore surprising that imaging studies of humans have not observed perirhinal activation during visual–tactile object matching. Critically, however, these studies did not differentiate between congruent and incongruent trials. This is important because successful integration can only occur when polymodal information indicates a single object (congruent) rather than different objects (incongruent). We scanned neurologically intact individuals using functional magnetic resonance imaging (fMRI) while they matched shapes. We found higher perirhinal activation bilaterally for cross-modal (visual–tactile) than unimodal (visual–visual or tactile–tactile) matching, but only when visual and tactile attributes were congruent. Our results demonstrate that the human perirhinal cortex is involved in cross-modal, visual–tactile, integration and, thus, indicate a functional homology between human and monkey perirhinal cortices

Entropic issues in contemporary cosmology

Penrose [1] has emphasized how the initial big bang singularity requires a special low entropy state. We address how recent brane cosmological schemes address this problem and whether they offer any apparent resolution. Pushing the start time back to $t=-\infty$ or utilizing maximally symmetric AdS spaces simply exacerbates or transfers the problem. Because the entropy of de Sitter space is $S\leq 1/\Lambda$, using the present acceleration of the universe as a low energy $(\Lambda\sim 10^{-120}$) inflationary stage, as in cyclic ekpyrotic models, produces a gravitational heat death after one cycle. Only higher energy driven inflation, together with a suitable, quantum gravity holography style, restriction on {\em ab initio} degrees of freedom, gives a suitable low entropy initial state. We question the suggestion that a high energy inflationary stage could be naturally reentered by Poincare recurrence within a finite causal region of an accelerating universe. We further give a heuristic argument that so-called eternal inflation is not consistent with the 2nd law of thermodynamics within a causal patch.Comment: brief discussion on Poincare recurrence include

A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK

BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c.118G > A in order to estimate the prevalence of the mutation in a referral population of GSD in the UK. RESULTS: This study demonstrated that the RFLP assay, based on use of PCR and subsequent digestion with the Eco571 enzyme, provided a simple genotyping test for the SOD1:c.118G > A mutation. In a young GSD population (i.e. dogs less than 6 years of age, before clinical signs of the disease usually become apparent), 8 of 50 dogs were found to be homozygous and a further 19 were heterozygous for the mutation. In dogs over 8 years of age, 21 of 50 dogs admitted to a tertiary referral hospital with pelvic limb ataxia as a major clinical sign were homozygous for the mutation, compared to none of 50 dogs of similar age, but where no neurological disease was reported on referral. CONCLUSIONS: This data suggests that genotyping for the SOD1:c.118G > A mutation is clinically applicable and that the mutation has a high degree of penetrance. Genotyping might also be useful for screening the GSD population to avoid mating of two carriers, but since the allele frequency is relatively high in the UK population of GSD, care should be taken to avoid reduction in genetic diversity within the breed

Nonexistence of conformally flat slices of the Kerr spacetime

Initial data for black hole collisions are commonly generated using the Bowen-York approach based on conformally flat 3-geometries. The standard (constant Boyer-Lindquist time) spatial slices of the Kerr spacetime are not conformally flat, so that use of the Bowen-York approach is limited in dealing with rotating holes. We investigate here whether there exist foliations of the Kerr spacetime that are conformally flat. We limit our considerations to foliations that are axisymmetric and that smoothly reduce in the Schwarzschild limit to slices of constant Schwarzschild time. With these restrictions, we show that no conformally flat slices can exist.Comment: 5 LaTeX pages; no figures; to be submitted to Phys. Rev.

An integrated LANDSAT/ancillary data classification of desert rangeland

Range inventorying methods using LANDSAT MSS data, coupled with ancillary data were examined. The study area encompassed nearly 20,000 acres in Rush Valley, Utah. The vegetation is predominately desert shrub and annual grasses, with some annual forbs. Three LANDSAT scenes were evaluated using a Kauth-Thomas brightness/greenness data transformation (May, June, and August dates). The data was classified using a four-band maximum-likelihood classifier. A print map was taken into the field to determine the relationship between print symbols and vegetation. It was determined that classification confusion could be greatly reduced by incorporating geomorphic units and soil texture (coarse vs fine) into the classification. Spectral data, geomorphic units, and soil texture were combined in a GIS format to produce a final vegetation map identifying 12 vegetation types

Functional specialization of the yeast Rho1 GTP exchange factors

Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs). Here, we examine the extent of and basis for functional specialization of the Rom2 and Tus1 GEFs that activate the yeast Rho1 GTPase, the ortholog of mammalian RhoA. First, we find that these GEFs selectively activate different Rho1-effector branches. Second, the synthetic genetic networks around ROM2 and TUS1 confirm very different global in vivo roles for these GEFs. Third, the GEFs are not functionally interchangeable: Tus1 cannot replace the essential role of Rom2, even when overexpressed. Fourth, we find that Rom2 and Tus1 localize differently: Rom2 to the growing bud surface and to the bud neck at cytokinesis; Tus1 only to the bud neck but in a distinct pattern. Finally, we find that these GEFs are dependent on different protein co-factors: Rom2 function and localization is largely dependent on Ack1, a SEL1 domain containing protein; Tus1 function and localization is largely dependent on the Tus1-interacting protein Ypl066w (which we name Rgl1). We have revealed a surprising level of diversity among the Rho1 GEFs that contributes another level of complexity to the spatiotemporal control of Rho1

Comments on "Limits on Dark Matter Using Ancient Mica"

To appear in Phys. Rev. Lett. together with the author's Reply.Comment: Compressed PostScript (filename.ps.Z), 3 pages, no figure

A Mid-Infrared Galaxy Atlas (MIGA)

A mid-infrared atlas of part of the Galactic plane ($75^\circ < l < 148^\circ, b = \pm6^\circ$) has been constructed using HIRES processed infrared data to provide a mid-infrared data set for the Canadian Galactic Plane Survey (CGPS). The addition of this data set to the CGPS will enable the study of the emission from the smallest components of interstellar dust at an angular resolution comparable to that of the radio, millimetre, and far-infrared data in the CGPS. The Mid-Infrared Galaxy Atlas (MIGA) is a mid-infrared (12 $\mu$m and 25 $\mu$m) counterpart to the far-infrared IRAS Galaxy Atlas (IGA), and consists of resolution enhanced ($\sim 0.5'$ resolution) HIRES images along with ancillary maps. This paper describes the processing and characteristics of the atlas, the cross-beam simulation technique used to obtain high-resolution ratio maps, and future plans to extend both the IGA and MIGA.Comment: 38 pages (including 15 tables), 13 figures (8 dithered GIF and 5 EPS). Submitted to Astrophysical Journal Supplement Series. A preprint with higher resolution figures is available at http://www.cita.utoronto.ca/~kerton/publications.htm