Society-wide scenarios for effective integration of Paris-aligned climate mitigation and adaptation in national and regional policy

Climate science (IPCC 2018) and economics (Emmerling et al. 2019; Burke, Hsiang, and Miguel 2015) indicates that achieving far earlier and deeper mitigation than pledged to date is likely now critical to effective climate action – particularly to ensure limits to adaptation are not breached. However, clear and coherent comparisons of national and regional climate action have been lacking. Therefore, here we summarise a benchmarking method (McMullin et al. 2019) to establish a prudent, fair share of the remaining global CO2 budget for any Party to the Paris Agreement. Using Ireland as a case study, we analyse current policy ambition relative to this benchmarked national CO2 quota, demonstrate early emergence of CO2 debt, and show tacit mitigation policy reliance on future large scale carbon dioxide removal (CDR). Toward society-wide scenarios for effective climate action, we further examine the crucial roles of non-CO2 mitigation and safeguarding land carbon stocks

Tiling strategies for optical follow-up of gravitational wave triggers by wide field of view telescopes

Binary neutron stars are among the most promising candidates for joint gravitational-wave and electromagnetic astronomy. The goal of this work is to investigate the strategy of using gravitational wave sky-localizations for binary neutron star systems, to search for electromagnetic counterparts using wide field of view optical telescopes. We examine various strategies of scanning the gravitational wave sky-localizations on the mock 2015-16 gravitational-wave events. We propose an optimal tiling-strategy that would ensure the most economical coverage of the gravitational wave sky-localization, while keeping in mind the realistic constrains of transient optical astronomy. Our analysis reveals that the proposed tiling strategy improves the sky-localization coverage over naive contour-covering method. The improvement is more significant for observations conducted using larger field of view telescopes, or for observations conducted over smaller confidence interval of gravitational wave sky-localization probability distribution. Next, we investigate the performance of the tiling strategy for telescope arrays and compare their performance against monolithic giant field of view telescopes. We observed that distributing the field of view of the telescopes into arrays of multiple telescopes significantly improves the coverage efficiency by as much as 50% over a single large FOV telescope in 2016 localizations while scanning around 100 sq. degrees. Finally, we studied the ability of optical counterpart detection by various types of telescopes. In Our analysis for a range of wide field-of-view telescopes we found improvement in detection upon sacrificing coverage of localization in order to achieve greater observation depth for very large field-of-view - small aperture telescopes, especially if the intrinsic brightness of the optical counterparts are weak.Comment: Accepted for publication in A&A. 10 pages, 10 figure

Modeling the maximum charge state of arginine-containing peptide ions formed by electrospray ionization

A model for the gas-phase proton transfer reactivity of multiply protonated molecules is used to quantitatively account for the maximum charge states of a series of arginine-contain- ing peptide ions measured by Downard and Biemann (Int. J. Mass Spectrom. Ion Processes 1995, 148, 191–202). We find that our calculations account exactly for the maximum charge state for 7 of the 10 peprides and are off by one charge for the remaining 3. These calculations clearly predict the trend in maximum charge states for these peptides and provide further evidence that the maximum charge state of ions formed by electrospray ionization is determined by their gas-phase proton transfer reactivity. (J Am Soc Mass Spectrom 1996, 7, 972–976

Metabolite profiling of yam (Dioscorea spp.) accessions for use in crop improvement programmes

Article purchased; Published online: 14 Oct. 2017Introduction Ninety-seven percent of yam (Dioscorea spp.) production takes place in low income food deficit countries (LIFDCs) and the crop provides 200 calories a day to approximately 300 million people. Therefore, yams are vital for food security. Yams have high-yield potential and high market value potential yet current breeding of yam is hindered by a lack of genomic information and genetic resources. New tools are needed to modernise breeding strategies and unlock the potential of yam to improve livelihood in LIFDCs. Objectives Metabolomic screening has been undertaken on a diverse panel of Dioscorea accessions to assess the utility of the approach for advancing breeding strategies in this understudied crop. Methods Polar and lipophilic extracts from tubers of accessions from the global yam breeding program have been comprehensively profiled via gas chromatography-mass spectrometry. Results A visual pathway representation of the measured yam tuber metabolome has been delivered as a resource for biochemical evaluation of yam germplasm. Over 200 compounds were routinely measured in tubers, providing a major advance for the chemo-typing of this crop. Core biochemical redundancy concealed trends that were only elucidated following detailed mining of global metabolomics data. Combined analysis on leaf and tuber material identified a subset of metabolites which allow accurate species classification and highlighted the potential of predicting tuber composition from leaf profiles. Metabolic variation was accessionspecific and often localised to compound classes, which will aid trait-targeting for metabolite markers. Conclusions Metabolomics provides a standalone platform with potential to deliver near-future crop gains for yam. The approach compliments the genetic advancements currently underway and integration with other ‘–omics’ studies will deliver a significant advancement to yam breeding strategies

Physical soil quality indicators for monitoring British soils

The condition or quality of soils determines its ability to deliver a range of functions that support ecosystem services, human health and wellbeing. The increasing policy imperative to implement successful soil monitoring programmes has resulted in the demand for reliable soil quality indicators (SQIs) for physical, biological and chemical soil properties. The selection of these indicators needs to ensure that they are sensitive and responsive to pressure and change e.g. they change across space and time in relation to natural perturbations and land management practices. Using a logical sieve approach based on key policy-related soil functions, this research assessed whether physical soil properties can be used to indicate the quality of British soils in terms of its capacity to deliver ecosystem goods and services. The resultant prioritised list of physical SQIs were tested for robustness, spatial and temporal variability and expected rate of change using statistical analysis and modelling. Six SQIs were prioritised; packing density, soil water retention characteristics, aggregate stability, rate of erosion, depth of soil and soil sealing. These all have direct relevance to current and likely future soil and environmental policy and are appropriate for implementation in soil monitoring programs

Evidence for a Molecular Cloud Origin for Gamma-Ray Bursts: Implications for the Nature of Star Formation in the Universe

It appears that the majority of rapidly-, well-localized gamma-ray bursts with undetected, or dark, optical afterglows, or `dark bursts' for short, occur in clouds of size R > 10L_{49}^{1/2} pc and mass M > 3x10^5L_{49} M_{sun}, where L is the isotropic-equivalent peak luminosity of the optical flash. We show that clouds of this size and mass cannot be modeled as a gas that is bound by pressure equilibrium with a warm or hot phase of the interstellar medium (i.e., a diffuse cloud): Such a cloud would be unstable to gravitational collapse, resulting in the collapse and fragmentation of the cloud until a burst of star formation re-establishes pressure equilibrium within the fragments, and the fragments are bound by self-gravity (i.e., a molecular cloud). Consequently, dark bursts probably occur in molecular clouds, in which case dark bursts are probably a byproduct of this burst of star formation if the molecular cloud formed recently, and/or the result of lingering or latter generation star formation if the molecular cloud formed some time ago. We then show that if bursts occur in Galactic-like molecular clouds, the column densities of which might be universal, the number of dark bursts can be comparable to the number of bursts with detected optical afterglows: This is what is observed, which suggests that the bursts with detected optical afterglows might also occur in molecular clouds. We confirm this by modeling and constraining the distribution of column densities, measured from absorption of the X-ray afterglow, of the bursts with detected optical afterglows: We find that this distribution is consistent with the expectation for bursts that occur in molecular clouds, and is not consistent with the expectation for bursts that occur in diffuse clouds. More...Comment: Accepted to The Astrophysical Journal, 22 pages, 6 figures, LaTe

Tiling strategies for optical follow-up of gravitational-wave triggers by telescopes with a wide field of view

Aims. Binary neutron stars are among the most promising candidates for joint gravitational-wave and electromagnetic astronomy. The goal of this work is to investigate various observing strategies that telescopes with wide field of view might incorporate while searching for electromagnetic counterparts of gravitational-wave triggers. Methods. We examined various strategies of scanning the gravitational-wave sky localizations on the mock 2015−16 gravitational-wave events. First, we studied the performance of the sky coverage using a naive tiling system that completely covers a given confidence interval contour using a fixed grid. Then we propose the ranked-tiling strategy where we sample the localization in discrete two-dimensional intervals that are equivalent to the telescope’s field of view and rank them based on their sample localizations. We then introduce an optimization of the grid by iterative sliding of the tiles. Next, we conducted tests for all the methods on a large sample of sky localizations that are expected in the first two years of operation of the Laser interferometer Gravitational-wave Observatory (LIGO) and Virgo detectors. We investigated the performance of the ranked-tiling strategy for telescope arrays and compared their performance against monolithic telescopes with a giant field of view. Finally, we studied the ability of optical counterpart detection by various types of telescopes. Results. Our analysis reveals that the ranked-tiling strategy improves the localization coverage over the contour-covering method. The improvement is more significant for telescopes with larger fields of view. We also find that while optimizing the position of the tiles significantly improves the coverage compared to contour-covering tiles. For ranked-tiles the same procedure leads to negligible improvement in the coverage of the sky localizations. We observed that distributing the field of view of the telescopes into arrays of multiple telescopes significantly improves the coverage efficiency, by as much as 50% over a single telescope with a large field of view in 2016 localizations while scanning ~100 deg2. Finally, through analyzing a range telescopes with wide field of view, we discovered that counterpart detection can be improved by sacrificing coverage of localization in order to achieve a greater observation depth for telescopes with very large field of view and small aperture, especially if the intrinsic brightness of the optical counterparts is weak

Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes

Aims/hypothesis: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes. Methods: A cohort of 1066 Scottish men and women aged 60–74 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study were followed up for a median of 6.7 years. New-onset reduced renal function was defined as two eGFRs <60 ml−1 min−1 (1.73 m)−2 at least 3 months apart with a > 25% decline from baseline eGFR. Ankle brachial pressure index (ABI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) were measured at baseline. Pulse wave velocity (PWV) and carotid intima media thickness were measured 1 year into follow-up. Data were analysed using Cox proportional hazards models. Results: A total of 119 participants developed reduced renal function during follow-up. ABI, PWV, NT-proBNP and hsTnT were all associated with onset of decline in renal function following adjustment for age and sex. These associations were attenuated after adjustment for additional diabetes renal disease risk factors (systolic BP, baseline eGFR, albumin:creatinine ratio and smoking pack-years), with the exception of hsTnT which remained independently associated (HR 1.51 [95% CI 1.22, 1.87]). Inclusion of hsTnT in a predictive model improved the continuous net reclassification index by 0.165 (0.008, 0.286). Conclusions/interpretation: Our findings demonstrate an association between hsTnT, a marker of subclinical cardiac ischaemia, and subsequent renal function decline. Further research is required to establish the predictive value of hsTnT and response to intervention

Adam Smith and the theory of punishment

A distinctive theory of punishment plays a central role in Smith's moral and legal theory. According to this theory, we regard the punishment of a crime as deserved only to the extent that an impartial spectator would go along with the actual or supposed resentment of the victim. The first part of this paper argues that Smith's theory deserves serious consideration and relates it to other theories such as utilitarianism and more orthodox forms of retributivism. The second part considers the objection that, because Smith's theory implies that punishment is justified only when there is some person or persons who is the victim of the crime, it cannot explain the many cases where punishment is imposed purely for the public good. It is argued that Smith's theory could be extended to cover such cases. The third part defends Smith's theory against the objection that, because it relies on our natural feelings, it cannot provide an adequate moral justification of punishment

Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans.

Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the perpendicular orientation. To understand the mechanism of spindle rotation, we characterized events that correlated temporally with rotation, including shortening of the spindle in the pole-to pole axis, which resulted in a nearly spherical spindle at rotation. By analyzing large spindles of polyploid C. elegans and a related nematode species, we found that spindle rotation initiated at a defined spherical shape rather than at a defined spindle length. In addition, dynein accumulated on the cortex just before rotation, and microtubules grew from the spindle with plus ends outward during rotation. Dynactin depletion prevented accumulation of dynein on the cortex and prevented spindle rotation independently of effects on spindle shape. These results support a cortical pulling model in which spindle shape might facilitate rotation because a sphere can rotate without deforming the adjacent elastic cytoplasm. We also present evidence that activation of spindle rotation is promoted by dephosphorylation of the basic domain of p150 dynactin