Effects of testosterone treatment on bone mineral density in hypogonadal men receiving intrathecal opioids

Background Opioid induced depression of sex hormones is a common finding in chronic pain patients receiving long-term opioids by oral, parenteral and even intrathecal routes of administration. The hypothalamic suppression by opioids leads to a hypogonadal state with low testosterone levels in males and subsequent low bone mineral density (BMD). Methods We have studied the effects of intrathecally administered opioids on BMD in a group of male chronic pain patients. In addition, we have studied the effects of supplementary testosterone on bone metabolism to see if the adverse effects of intrathecal opioids can be reversed. Results Eleven of the 27 patients were on supplementary testosterone having previously been diagnosed as hypogonadal with low serum testosterone. Duration of testosterone supplementation was greater than 2 years in all 11 patients. Both serum total and free testosterone levels were higher in patients on supplementary testosterone than in patients who did not receive this treatment. Of the 16 patients not on testosterone supplement, 14 (87%) had low serum testosterone levels (<10 nmol/L) and 11 (69%) had low or osteoporotic T scores. Within this group, low free testosterone was associated with low BMD scores, and this persisted after correcting for age. Eight of the patients on testosterone supplement had normal BMDT scores and three (27%) had low or osteoporotic T scores. T and age-corrected BMDZ scores were significantly greater in the 11 patients on testosterone supplements than BMD scores in the other 16 patients. Conclusion Testosterone supplementation was found to largely correct the effects of intrathecal opioids on testosterone levels and BMD

Layer dynamics of a freely standing smectic-A film

We study the hydrodynamics of a freely-standing smectic-A film in the isothermal, incompressible limit theoretically by analyzing the linearized hydrodynamic equations of motion with proper boundary conditions. The dynamic properties for the system can be obtained from the response functions for the free surfaces. Permeation is included and its importance near the free surfaces is discussed. The hydrodynamic mode structure for the dynamics of the system is compared with that of bulk systems. We show that to describe the dynamic correlation functions for the system, in general, it is necessary to consider the smectic layer displacement $u$ and the velocity normal to the layers, $v_z$, together. Finally, our analysis also provides a basis for the theoretical study of the off-equilibrium dynamics of freely-standing smectic-A films.Comment: 22 pages, 4 figure

Plasma Wave Properties of the Schwarzschild Magnetosphere in a Veselago Medium

We re-formulate the 3+1 GRMHD equations for the Schwarzschild black hole in a Veselago medium. Linear perturbation in rotating (non-magnetized and magnetized) plasma is introduced and their Fourier analysis is considered. We discuss wave properties with the help of wave vector, refractive index and change in refractive index in the form of graphs. It is concluded that some waves move away from the event horizon in this unusual medium. We conclude that for the rotating non-magnetized plasma, our results confirm the presence of Veselago medium while the rotating magnetized plasma does not provide any evidence for this medium.Comment: 20 pages, 15 figures, accepted for publication in Astrophys. Space Sc

Exchange-correlation vector potentials and vorticity-dependent exchange-correlation energy densities in two-dimensional systems

We present a new approach how to calculate the scalar exchange-correlation potentials and the vector exchange-correlation potentials from current-carrying ground states of two-dimensional quantum dots. From these exchange-correlation potentials we derive exchange-correlation energy densities and examine their vorticity (or current) dependence. Compared with parameterizations of current-induced effects in literature we find an increased significance of corrections due to paramagnetic current densities.Comment: 5 figures, submitted to PR

Wave Propagation in Gravitational Systems: Late Time Behavior

It is well-known that the dominant late time behavior of waves propagating on a Schwarzschild spacetime is a power-law tail; tails for other spacetimes have also been studied. This paper presents a systematic treatment of the tail phenomenon for a broad class of models via a Green's function formalism and establishes the following. (i) The tail is governed by a cut of the frequency Green's function $\tilde G(\omega)$ along the $-$~Im~$\omega$ axis, generalizing the Schwarzschild result. (ii) The $\omega$ dependence of the cut is determined by the asymptotic but not the local structure of space. In particular it is independent of the presence of a horizon, and has the same form for the case of a star as well. (iii) Depending on the spatial asymptotics, the late time decay is not necessarily a power law in time. The Schwarzschild case with a power-law tail is exceptional among the class of the potentials having a logarithmic spatial dependence. (iv) Both the amplitude and the time dependence of the tail for a broad class of models are obtained analytically. (v) The analytical results are in perfect agreement with numerical calculations

Wigner Crystalization in the Lowest Landau Level for ν≥1/5\nu \ge 1/5

By means of exact diagonalization we study the low-energy states of seven electrons in the lowest Landau level which are confined by a cylindric external potential modelling the rest of a macroscopic system and thus controlling the filling factor $\nu$. Wigner crystal is found to be the ground state for filling factors between $\nu = 1/3$ and $\nu = 1/5$ provided electrons interact via the bare Coulomb potential. Even at $\nu =1/5$ the solid state has lower energy than the Laughlin's one, although the two energies are rather close. We also discuss the role of pseudopotential parameters in the lowest Landau level and demonstrate that the earlier reported gapless state, appearing when the short-range part of the interaction is suppressed, has nothing in common with the Wigner crystalization in pure Coulomb case.Comment: 9 pages, LaTex, 8 figure

Magnetic field dependence of the exciton energy in a quantum disk

The groundstate energy and binding energy of an exciton, confined in a^M quantum disk, are calculated as a function of an external magnetic field. The confinement potential is a hard wall of finite height. The diamagnetic shift is investigated for magnetic fields up to 40$T$. Our results are applied to $In_{y}Al_{1-y}As/Al_{x}Ga_{1-x}As$ self-assembled quantum dots and very good agreement with experiments is obtained. Furthermore, we investigated the influence of the dot size on the diamagnetic shift by changing the disk radius. The exciton excited states are found as a function of the magnetic field. The relative angular momentum is not a quantum number and changes with the magnetic field strength.Comment: 10 pages, 17 figure

Isothermal Plasma Wave Properties of the Schwarzschild de-Sitter Black Hole in a Veselago Medium

In this paper, we study wave properties of isothermal plasma for the Schwarzschild de-Sitter black hole in a Veselago medium. We use ADM 3+1 formalism to formulate general relativistic magnetohydrodynamical (GRMHD) equations for the Schwarzschild de-Sitter spacetime in Rindler coordinates. Further, Fourier analysis of the linearly perturbed GRMHD equations for the rotating (non-magnetized and magnetized) background is taken whose determinant leads to a dispersion relation. We investigate wave properties by using graphical representation of the wave vector, the refractive index, change in refractive index, phase and group velocities. Also, the modes of wave dispersion are explored. The results indicate the existence of the Veselago medium.Comment: 24 pages, 12 figures, accepted for publication in Astrophys. Space Sci. arXiv admin note: text overlap with arXiv:1101.0884 and arxiv:1007.285

CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography

Since the first proof of concept in the early 70s, a number of technologies has been proposed to perform proton CT (pCT), as a means of mapping tissue stopping power for accurate treatment planning in proton therapy. Previous prototypes of energy-range detectors for pCT have been mainly based on the use of scintillator-based calorimeters, to measure proton residual energy after passing through the patient. However, such an approach is limited by the need for only a single proton passing through the energy-range detector in a read-out cycle. A novel approach to this problem could be the use of pixelated detectors, where the independent read-out of each pixel allows to measure simultaneously the residual energy of a number of protons in the same read-out cycle, facilitating a faster and more efficient pCT scan. This paper investigates the suitability of CMOS Active Pixel Sensors (APSs) to track indi- vidual protons as they go through a number of CMOS layers, forming an energy-range telescope. Measurements performed at the iThemba Laboratories will be presented and analysed in terms of correlation, to confirm capability of proton tracking for CMOS APSs

Frictional drag between non-equilibrium charged gases

The frictional drag force between separated but coupled two-dimensional electron gases of different temperatures is studied using the non-equilibrium Green function method based on the separation of center-of-mass and relative dynamics of electrons. As the mechanisms of producing the frictional force we include the direct Coulomb interaction, the interaction mediated via virtual and real TA and LA phonons, optic phonons, plasmons, and TA and LA phonon-electron collective modes. We found that, when the distance between the two electron gases is large, and at intermediate temperature where plasmons and collective modes play the most important role in the frictional drag, the possibility of having a temperature difference between two subsystems modifies greatly the transresistivity.Comment: 8figure