Universal relations for quasinormal modes of neutron stars in R2R^2 gravity

We construct quasinormal modes for neutron stars in $R^2$ gravity in the Einstein frame, considering scalar masses in the sub-neV range. In particular, we investigate the fundamental quadrupole fluid f-modes and the dipole fluid F-modes. Employing six equations of state covering matter content with nucleons, hyperons, and quarks, we then propose universal relations for the quadrupole f-modes and dipole F-modes. The dipole F-modes are ultra-long lived and, for the lower scalar masses, their frequencies are inversely proportional to the corresponding Compton wavelength.Comment: 25 pages, 23 figures; Some figures update

Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

In biology-oriented synthesis, the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is, in particular, met by the scaffolds of natural products selected in evolution. The synthesis of natural product-inspired compound collections calls for efficient reaction sequences that preferably combine multiple individual transformations in one operation. Here we report the development of a one-pot, twelve-step cascade reaction sequence that includes nine different reactions and two opposing kinds of organocatalysis. The cascade sequence proceeds within 10-30 min and transforms readily available substrates into complex indoloquinolizines that resemble the core tetracyclic scaffold of numerous polycyclic indole alkaloids. Biological investigation of a corresponding focused compound collection revealed modulators of centrosome integrity, termed centrocountins, which caused fragmented and supernumerary centrosomes, chromosome congression defects, multipolar mitotic spindles, acentrosomal spindle poles and multipolar cell division by targeting the centrosome-associated proteins nucleophosmin and Crm1