Comments on Marine Litter in Oceans, Seas and Beaches: Characteristics and Impacts.

Marine litter is observed along shorelines, pelagic, benthic marine and lake systems all around the globe. On beaches, litter creates aesthetic and related economic problems because a clean beach is one of the most important characteristics of a seaside resort required by visitors. Litter can reach the marine environment from marine or land activities but it is estimated that 80% originates from land-based sources. The marine-based sources of litter include all types of sea-going vessel and offshore installations, the most abundant plastic debris in the oceans being derelict (lost or improperly discarded) fishing gear. Most of marine litter is composed by plastics due to their greater durability and persistence, combined with plastic rising production and low rates of recovery. Special importance is linked to microplastics because their ubiquity, persistence, mechanical effects on biota and the ecosystem because of ingestion by organisms and their toxic potential. As plastics degrade they can release toxic chemicals initially incorporated during their manufacturing or persistent organic pollutants and heavy metals sorbed to their surfaces in the environment. Such toxins can disrupt endocrine functions and cause harmful reproductive and developmental effects in aquatic animals

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross-sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, -0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40-ligand (P = 0.0238), soluble Nox2-derived peptide (sNox2-dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD4OL (Spearman's rank correlation coefficient [r(s)], -0.33; P < 0.001), sNox2-dp (r(s), -0.57; P < 0.0001), and urinary excretion of isoprostanes (r(s), -0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2-dp, and urinary 8-iso prostaglandin F2 alpha-III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2-dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation

[Study of diagnostic features, health care quality and surgical treatment among women living in the LHAs of Novara and Verbano Cusio Ossola hospitalized for breast cancer]

This study included 304 women, 128 Screen Detected (SD) e 176 non Screen Detected (NSD), aged 50-69, living in the ex-local health authorities (LHAs) 13 and 14, hospitalized for breast cancer or related chemotherapy or radiation treatments in 2003-2004. Some variables were detected from medical records in order to evaluate the local screening program. The results confirm that a prevention activity allows a rapid identification of cancer and less invasive surgery procedures