391 research outputs found

    Automating {UML} Models Merge for Web Services Testing

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    International audienceThis paper presents a method for merging UML models which takes place in a quality evaluation framework for Web Services (WS). This framework, called iTac-QoS, is an ex- tended UDDI server (a yellow pages system dedicated to WS), using model based testing to assess quality. WS ven- dors have to create UML model of their product and our framework extracts tests from it. Depending on the results of the test execution, a mark is given to WS. This mark per- mits to customers to have an idea about the quality of WS they find on our UDDI server. Up today, our framework was limited to WS which did not use other WS. This was justified by the fact that it is im- possible for vendors to create a good model of a foreign product. Our method for model merging solves this prob- lem: each vendor produces models of its own product, and we automatically merge the different models. The resulting model from this merging represents the composition of the different WS. For each type of diagram present in the models (class, instance or state-chart diagram), a method is proposed in order to produce a unique model. In addition to this, a solu- tion is proposed to merge all OCL code in the class modeling the WS under test. Unfortunately, this process introduces inconsistencies in the resulting model, that falsify the results of the subsequent test generation phase. We thus propose to detect such inconsistencies in order to distinguish incon- sistent and unreachable test targets

    Time-resolved studies of ytterbium distribution at interfacial surfaces of ferritin-like dps protein demonstrate metal uptake and storage pathways

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    Cage-shaped protein (CSP) complexes are frequently used in bionanotechnology, and they have a variety of different architectures and sizes. The smallest cage-shaped protein, Dps (DNA binding protein from starved cells), can naturally form iron oxide biominerals in a multistep process of ion attraction, translocation, oxidation, and nucleation. The structural basis of this biomineralization mechanism is still unclear. The aim of this paper is to further develop understanding of this topic. Time-resolved metal translocation of Yb3+ ions has been investigated on Dps surfaces using X-ray crystallography. The results reveal that the soak time of protein crystals with Yb3+ ions strongly affects metal positions during metal translocation, in particular, around and inside the ion translocation pore. We have trapped a dynamic state with ongoing translocation events and compared this to a static state, which is reached when the cavity of Dps is entirely filled by metal ions and translocation is therefore blocked. By comparison with La3+ and Co2+ datasets, the time-dependence together with the coordination sphere chemistry primarily determine metal−protein interactions. Our data can allow structure-based protein engineering to generate CSPs for the production of tailored nanoparticles

    Melody valve to replace the mitral valve in small children: Lessons learned

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    Objective Infants requiring mitral valve replacement have few viable options. Recently, stented bovine jugular vein graft (Melody) has been surgically implanted in such cases. Herein, we report our experience, elaborating on evolution of implantation technique, pitfalls, as well as long-term outcome (including late dilatability). Methods Seven Melody valves were implanted (2013-2019). The median patient age and weight were 6.7 (1.8-30.5) months and 5.8 (4.6-9.5) kg, respectively. The indications for implantation were mitral stenosis and/or regurgitation postatrioventricular septal defect (AVSD) repair (5), congenital mitral valve dysplasia (1), and Shone's complex (1). Operative technique involved shortening the valve and creating a neo-sewing ring at 2/3 (atrial)-1/3 (ventricular) junction. Implantation was followed by intraoperative balloon dilatation. Results Five out of seven patients survived the perioperative period (one death due to technical failure and the other due to acute respiratory distress syndrome postcardiopulmonary bypass). Two out of five medium-term survivors got transplanted (1) or died due to acute myeloid leukemia (1). No valves were replaced. The mean echo gradient at discharge was a median 4 (2-6) mmHg. None of the patients showed left ventricular outflow tract or pulmonary venous obstruction. Two Melody valves were dilated late (5 months and 3 years postoperatively), resulting in decreasing mean gradients from 6 to 1 and from 17 to 4 mmHg. At last follow-up, surviving Melody had a mean gradient of 4 (1-9) mmHg. Conclusions Mitral valve replacement with a Melody valve is feasible in infants, is reproducible, shows good immediate results, and offers the possibility of later dilatation. This technique offers a better solution compared to the existing alternatives for infants requiring a prosthetic mitral valve

    A Video Transmission Framework Using Components and Multi-Agent Systems

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    International audienceThis paper presents an application of video transmission over Internet, which goal is to be used in a cooperative plat- form. This application uses proxies during the transmission to adapt the video (changing the size, the framerate and/or the encoding format). Adaptation is a necessity in this kind of application, due to the diversity of receivers (computers, mobile phones, PDA . . . ). During the design process, we chose to use component ori- ented programming and multi-agent systems. We present here how these two paradigms help us to have a flexible and evolutive application, and, for each transmission?s step, what is the most appropriated solution. At the end, we also present tests that have been made to evaluate the power needed by the proxies in order to discuss about benefits that can be brought by our architecture

    Automated UML models merging for web services testing

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    International audienceThis paper presents a method for merging UML models which takes place in a quality evaluation framework for Web Services (WS). This framework, called iTac-QoS, is an extended UDDI server (a yellow pages system dedicated to WS), using model based testing to assess quality. WS vendors have to create UML model of their product and our framework extracts tests from it. Depending on the results of the test execution, a mark is given to WS. This mark gives to the cus- tomers an idea about the quality of WS they find on our UDDI server. Up today, our framework was limited to WS which did not use other WS. This was justified by the fact that it is impossible for vendors to cre- ate a good model of a foreign product. Our method for model merging solves this problem: each vendor produces models of its own product, and we automatically merge the different models. The resulting model from this merging represents the composition of the different WS. For each type of diagram present in the models (class, instance or state- chart diagram), a method is proposed in order to produce a unique model. In addition to this, a solution is proposed to merge all OCL code in the class modeling the WS under test. Unfortunately, this pro- cess introduces inconsistencies in the resulting model, that falsify the results of the subsequent test generation phase. We thus propose to detect such inconsistencies in order to distinguish inconsistent and un- reachable test targets

    Repair of postinfarction dyskinetic LV aneurysm with either linear or patch technique

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    Objectives: Controversy still exists regarding the optimal surgical technique for postinfarction dyskinetic left ventricular aneurysm (LVA) repair. We compared the efficacy of two established techniques, linear vs. patch remodeling, for repair of dyskinetic LVA. Patients and methods: From 1989 to 1998, 95 (16 women, 79 men) consecutive patients were operated on for postinfarction dyskinetic LVA. Thirty-four patients underwent patch remodeling (R) and 61 linear (L) repair. The mean age was 61.1±8.5 years. Indications for surgery alone or in combination included angina in 72 patients, dyspnea in 64 and ventricular tachycardia in 41. Thirty-seven patients had a history of congestive heart failure (R 13 (38%), L 24 (39%), NS). The mean ejection fraction (EF) with aneurysm was 0.29±0.09 in R vs. 0.35±0.10 in L (Pâ‰Ș0.04), whereas the mean EF without aneurysm was 0.43±0.11 in R vs. 0.46±0.08 in L (P=0.3). Seventy-one aneurysms were anterior (R 30 (88%), L 41 (68%), Pâ‰Ș0.05). Concomitant coronary artery bypass grafting was performed in 84 patients (R 29 (85%), L 55 (90%), NS). Follow-up ranged from 1 to 12 years (mean 5.6±3.4 years, median 6.1 years). Results: Early mortality was 8% (n=8) (R 4, L 4, NS). Survival at 1, 5 and 10 years was 88, 73, and 44%, respectively. It did not differ significantly between R (1 and 5 year survival 85, 66%) and L (90, 76%, P=0.58). Preoperative risk factors for mortality were history of congestive heart failure (1 and 5 year survival 81 and 57% vs. 90 and 78%, respectively, hazard ratio (HR)=1.95, Pâ‰Ș0.05), non-anterior localization of the aneurysm (86 and 49% vs. 86 and 77%, HR=2.06, Pâ‰Ș0.05), history of thromboembolic events (57 and 19% vs. 89 and 74%, HR=3.27, Pâ‰Ș0.05), and left ventricular EF (HR=0.97 per %, P=0.05). At late follow-up the mean functional class was 1.8±0.6 in long-term survivors (preoperative 2.9±0.9, Pâ‰Ș0.001) with no difference between the groups. Conclusions: The technique of repair of postinfarction dyskinetic LVA should be adapted in each patient to the cavity size and extent of the scarring process into the septum and subvalvular mitral apparatus. Applying these considerations to the choice of the technique of repair, both techniques achieved satisfactory results with respect to perioperative mortality, late functional status and surviva

    Results of surgery for irreversible moderate to severe mitral valve regurgitation secondary to myocardial infarction

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    Objective: Moderate to severe irreversible mitral regurgitation secondary to myocardial infarction is an independent risk factor for reduced long-term survival. Late effects of correction of mitral incompetence concomitant with coronary artery bypass grafting (CABG) are less well known and the choice of mitral valve procedure is still debated. Methods: From 1988 to 1998, 93 consecutive patients (mean age 63±9 years) were treated for moderate to severe irreversible mitral regurgitation secondary to myocardial infarction; 84 were in NYHA functional class III-IV and 19 were in cardiogenic shock. Thirty-seven patients underwent emergency surgery. Perioperative intraaortic balloon pump (IABP) was necessary in 33 patients. Follow-up ranged from 6 months to 12 years (mean 51 months±41). Results: Mitral valve was repaired in 30 patients and replaced in 63. Replacement was preferably performed in patients with major displacement of papillary muscle and in patients with acute papillary muscle rupture. CABG (3.4 distal anastomoses) was performed in all patients and was complete in 92%. Early mortality was 15% (14/93). Multivariable analysis identified need for IABP (P=0.005) and COPD (P=0.02) as risk factors for early death. Emergency surgery had only a trend (P=0.15) for increased mortality; age, low ejection fraction, repair vs. replacement had no influence. Actuarial survival rates at 1, 5 and 10 years were 81, 65 and 56%, respectively. Late survival was similar in patients with replacement or repair (P=0.46). At last follow-up, all but one patient were in NYHA functional class I or II. Conclusions: Combined mitral valve procedure and myocardial revascularization, as complete as possible, for moderate to severe mitral regurgitation secondary to myocardial infarction achieve satisfactory early and late outcome despite the increased operative mortality. Acute papillary muscle rupture, severe restriction of the mitral valve by major displacement of the papillary muscle are better managed by valve replacemen

    Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance

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    Aims Correct timing of pulmonary valve replacement (PVR) is crucial for preventing complications of pulmonary regurgitation and right ventricular (RV) dilatation after repair of tetralogy of Fallot. We sought to assess the remodelling of the RV after early PVR in children, using cardiovascular magnetic resonance (CMR). Methods and results Twenty children with severe pulmonary regurgitation and RV dilatation and mean age 13.9±3 years underwent CMR evaluation 5.6±1.8 months before and 5.9±0.6 months after PVR. PVR was performed when the RV end-diastolic volume exceeded 150 mL/m2, as measured by CMR. The time interval between primary repair and PVR was 12±3 years. Post-operative CMR demonstrated a significant reduction of the RV end-diastolic volume from 189.8±33.4 to 108.7±25.8 mL/m2 (P<0.0001), of the RV end-systolic volume from 102.4±27.3 to 58.2±16.3 mL/m2 (P<0.0001), and of the RV mass from 48.7±12.3 to 35.8±7.7 g/m2 (P<0.0001). The RV ejection fraction did not change significantly. Conclusion Prompt RV remodelling, with reduction of RV volume and mass, is observed after performing PVR if the RV end-diastolic volume exceeds 150 mL/m2. Early PVR may prevent the detrimental complications of severe pulmonary regurgitatio
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