Ethyl 1-cyclo­hexyl-5-(4-meth­oxy­phen­yl)-1H-pyrazole-4-carboxyl­ate

In the title compound, C19H24N2O3, the benzene ring forms a dihedral angle of 65.34 (7)° with the pyrazole ring. The cyclo­hexane ring adopts a chair conformation. In the crystal, mol­ecules are linked into a inversion dimers by pairs of C—H⋯O hydrogen bonds, generating R 2 2(22) ring motifs

Iodine-catalyzed aza-diels-alder reactions of aliphatic n-arylaldimines

Iodine-catalyzed aza-Diels-Alder (Povarov) reaction of 3,4-dihydro-2H-pyran with in situ generated N-arylimines containing enolizable protons is described. This has given an easy way to introduce C-2 aliphatic substitution in tetrahydroquinolines

Design, synthesis, characterization, and antibacterial activity of 5-chloro-2-(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy-phenyl-(phenyl)-methanones

In the present investigation, a series of novel 5-chloro-2-(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)-methoxy-phenyl-(phenyl)-methanones (3a–i) have been synthesized from 5-(chloromethyl)-3-substitutedphenyl-1,2,4-oxadiazole (2a–i). The newly synthesized compounds were characterized by IR, NMR (1H and 13C), mass spectral and elemental analysis. The title compounds were investigated for in-vitro qualitative (zone of inhibition) and quantitative (MIC) antibacterial activity by agar cup plate and microtitration methods, respectively. The minimum inhibitory concentration and structure activity relationships (SARs) were evaluated. Amongst the synthesized compounds in this series, 5-chloro-2-(3-(2,5-difluoro-4-methyl-phenyl)-1,2,4-oxadiazol-5-yl)-methoxy-phenyl-(phenyl)-methanone (3d) was found to exhibit significant activity with MICs of 21.5, 22.4, 29.8 and 30.6μg/mL against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, respectively

Synthesis of Some Novel 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles as potent anti-inflammatory agents

A series of 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles 4a–j were obtained via multiple step synthesis sequence beginning with the hydroxybenzophenones (1a–g). Hydroxybenzophenones on reaction with chloroacetonitrile affords (2-benzoyl) phenoxy acetonitrile (2a–g), which reacts with H2S/NH4OH and yields (2-benzoyl) phenoxy acetothiamide (3a–g), which on treatment with phenacylbromides affords 2-2-(aroyl-aroxy)-methyl-4-phenyl-1,3-thiazoles (4a–j). All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, (4g), compounds with chloro substituents showed more potent activity than the standard drug phenyl butazone at all doses tested