Imagine coastal sustainability

Since 2000 Coastal Area Management Programmes (CAMPs) supported by UNEP Mediterranean Action Plan (MAP) and the Priority Actions Programme Regional Activity Centre (PAP/RAC) have been engaging local communities in assessment of their coastal sustainability. The Methods used since 2000 have been based upon an evolving methodology which is now called Imagine. In 2010 The CAMP Levante de Almeria began. “Imagine the future of our coast” is the slogan selected for this project which is intended to turn this area of southern Spain into a sustainability laboratory. The CAMP Levante de Almeria project is a test and a practical demonstration of how to implement Integrated Coastal Zone Management (ICZM) concepts in Spain in compliance with the ICZM Protocol (the seventh protocol in the framework of the Barcelona Convention). CAMP acts technically, environmentally and socially as a means to design and implement new practices, relating these to vertical and horizontal coordination between local and regional administration and public participation in decision-making processes related to the coastal zone. The fundamental objective of the project is to achieve wide scale agreement on the sustainable development of the coast. Drawing upon the history of the various CAMP projects, this paper explores progress made so far in the application of the Imagine methodology in CAMP Levante de Almeria and, by contrasting it with summary observations emerging from earlier Imagine applications in Malta, Lebanon, Algeria, Slovenia and Cyprus draws conclusions on the value of engaging coastal communities in sustainability self-assessment

Masterprojekt Zweitwohnsitz im alpinen Raum. Gesamtbericht WS 2020/21

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D 8.2 Policy Guidelines for User Protection, Long Term Operational Resilience and Cross-Modal Transferability between Air and Surface-based Transport Sectors

This deliverable presents a review of occurrence of delay in air travel, of the role of weather, and of policy guidelines to reduce delays, notably when caused by adverse weather. Furthermore, the EU is compared to the US, China and Australia

Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype

Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in COVID-19. RNA-seq analysis showed a more than 4-fold increased expression of IL-6 , ICAM-1 , CXCL-8 , and SCGB1A1 inflammatory factors; MUC5AC and  MUC5B mucins; and SPDEF , FOXA3 , and FOXJ1 transcription factors in COVID-19 patient nasal samples compared with uninfected controls. A lncRNA on antisense strand to ICAM-1 or LASI was induced 2-fold in COVID-19 patients, and its expression was directly correlated with viral loads. A SARS-CoV-2-infected 3D-airway model largely recapitulated these clinical findings. RNA microscopy and molecular modeling indicated a possible interaction between viral RNA and LASI lncRNA. Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI -dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated. Thus, LASI lncRNA represents an essential facilitator of SARS-CoV-2 infection and associated airway mucoinflammatory response. • COVID19 airway mucoinflammatory response strongly correlates with LASI lncRNA level • Silencing LASI lncRNA suppresses SARS-CoV-2 viral load and associated inflammation • LASI lncRNA shows a potential direct interaction with SARS-CoV-2 spike viral RNA • Hosts of airway epithelial miRNAs are modulated by LASI to regulate inflammation Molecular biology; Molecular mechanism of gene regulation; Immunology; Virolog

Indirect (implicit) and direct (explicit) self-esteem measures are virtually unrelated: A meta-analysis of the initial preference task.

BACKGROUND:The initial preference task (IPT) is an implicit measure that has featured prominently in the literature and enjoys high popularity because it offers to provide an unobtrusive and objective assessment of self-esteem that is easy to administer. However, its use for self-esteem assessment may be limited because of weak associations with direct personality measures. Moreover, moderator effects of sample- and study-related variables need investigation to determine the value of IPT-based assessments of self-esteem. METHODS:Conventional and grey-literature database searches, as well as screening of reference lists of obtained articles, yielded a total of 105 independent healthy adult samples (N = 17,777) originating from 60 studies. Summary effect estimates and subgroup analyses for potential effect moderators (e.g., administration order, algorithm, rating type) were calculated by means of meta-analytic random- and mixed-effects models. Moreover, we accounted for potential influences of publication year, publication status (published vs. not), and participant sex in a weighted stepwise hierarchical multiple meta-regression. We tested for dissemination bias through six methods. RESULTS:There was no noteworthy correlation between IPT-based implicit and explicit self-esteem (r = .102), indicating conceptual independence of these two constructs. Effects were stronger when the B-algorithm was used for calculation of IPT-scores and the IPT was administered only once, whilst all other moderators did not show significant influences. Regression analyses revealed a somewhat stronger (albeit non-significant) effect for men. Moreover, there was no evidence for dissemination bias or a decline effect, although effects from published studies were numerically somewhat stronger than unpublished effects. DISCUSSION:We show that there is no noteworthy association between IPT-based implicit and explicit self-esteem, which is broadly consistent with dual-process models of implicit and explicit evaluations on the one hand, but also casts doubt on the suitability of the IPT for the assessment of implicit self-esteem on the other hand