Denovo generated human red blood cells in humanized mice support Plasmodium falciparum infection

10.1371/journal.pone.0129825PLoS ONE106e012982

Differential spleen remodeling associated with different levels of parasite virulence controls disease outcome in malaria parasite infections

10.1128/mSphere.00018-15mSphere11e00018-1

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites

10.1371/journal.ppat.1000104PLoS Pathogens47e100010

Targeted phenotypic screening in Plasmodium falciparum and Toxoplasma gondii reveals novel modes of action of Medicines for Malaria Venture Malaria Box molecules

10.1128/mSphere.00534-17mSphere31e00534-1

Synthesis, characterization and in vitro evaluation of novel enantiomerically-pure sulphonamide antimalarials

Malaria parasites are currently gaining drug-resistance rapidly, across countries and continents. Hence, the discovery and development of novel chemical scaffolds, with superior antimalarial activity remain an important priority, for the developing world. Our report describes the development, characterization and evaluation of novel bepotastine-based sulphonamide antimalarials inhibiting asexual stage development of Plasmodium falciparum parasites in vitro. The screening results showed potent inhibitory activity of a number of novel sulphonamides against P. falciparum at low micromolar concentrations, in particular in late-stage parasite development. Based on computational studies we hypothesize N-myristoyltransferase as the target of the compounds developed here. Our results demonstrate the value of novel bepotastine-based sulphonamide compounds for targeting the asexual developmental stages of P. falciparum. © 2015 The Royal Society of Chemistry

Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection.

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