59 research outputs found
Stable Gastric PentadecapeptideBPC 157, Somatosensory Neurons and Their Protection and Therapeutic Extensions — A Survey
BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats
Providing NO-system importance, we suggest that one single application of the NOS-blocker L-NAME may induce retinal ischemia in rats, and that the stable pentadecapeptide BPC 157 may be the therapy, since it may interact with the NO-system and may counteract various adverse effects of L-NAME application. A rat retinal ischemia study was conducted throughout 4 weeks, including fundoscopy, behavior presentation, tonometry, and histology assessment. Retrobulbar L-NAME application (5 mg/kg; 0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage. The specific L-NAME–induced vascular failure points to normal intraocular pressure (except to very transitory increase upon drug retrobulbar administration). When BPC 157 (10 μg; 10 ng/kg, as retrobulbar application, 1 μg; 1 ng/0.1 ml saline/each eye) is given at either 20 min after L-NAME or, lately, at 48 h after L-NAME, the regular retrobulbar L-NAME injection findings disappear. Instead, fundoscopy demonstrated only discrete generalized vessel caliber irregularity with mild atrophy of the optic disc, and then, quite rapidly, normal eye background and choroidal blood vessels, which remain in all of the subsequent periods. Also, histology assessment at 1, 2, and 4 weeks shows that BPC 157 counteracted the damaged inner plexiform layer and inner nuclear layer, and revealed normal retinal thickness. The poor behavioral presentation was also rescued. Thus, while further studies will be done, BPC 157 counteracted L-NAME–induced rat retinal ischemia
Sa1956 Stable Gastric Pentadecapeptide BPC 157 Protects Against Pertinent Ischemic Challenge (Left Gastric Artery Ligation) in Rats
Mo1249 The Healing of Colocutaneous Fistulas and Diclofenac Overdose. The Role of Pentadecapeptide BPC 157
Editorial: Protection and healing in the digestive system and other tissues : novel factors, mechanisms, and pharmaceutical targets
Mo1827 The Pentadecapeptide BPC 157 Heals Chronic Lesions and Prevents Recurrences At the Colocutaneous Fistulas Model in Rats
Tu1959 Effect of Pentadecapeptide BPC 157 on Liver Lesions Induced by Biliary Obstruction in Rats
587 – Pentadecapeptide Bpc 157 Therapy in Bile Duct Ligated (BDL) Rats. in the Liver Tissue, Bpc 157 Counteracts the Increased Nos3 Expression, Il-6, TNF-Α, Il-1Β Levels, and Ki-67 Presentation
W1338 The Pentadecapeptide BPC 157 Effective in Healing the Colon-Colon Anastomosis Complicated With Cysteamine Induced Colitis
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