Study of the Efficacy of CC-2 and Fuller's Earth Combination as a Decontaminant against Sulphur Mustard (Mustard Gas) Dermal Intoxication in Mice

Decontamination efficacy of Fuller's earth and CC-2 independently; and in different combinations was evaluated against toxicity of sulphur mustard applied percutaneously on mice. Maximum protection was obtained with Fuller's earth and CC-2 in a combination of 80:20(w/w)

Studies on Effect of Chemical Preservatives on Physico-Chemical Changes of Beverages in Lime and Ginger Juice with their Combinations

The physico-chemical character of lime and ginger RTS and blended RTS were evaluated after addition of potassium meta-bi-sulphite (KMS) and sodium benzoate stored at ambient temperature up to 150 days. Lime and ginger RTS preserved with KMS (0.1%) retained more ascorbic acid and acidity as compared to other treatments. During storage, total soluble solids, reduction and total sugars showed an increasing trend with increasing period of storage under ambient condition in KMS (0.1%) as compared to other treatments. Among the various treatment RTS prepared from ginger juice with KMS 0.1% could be stored for extended period of time for sensory characteristics

Genetic variability studies for yield and its contributing traits in okra [Abelmoschus esculentus (L.) Moench]

The experiment comprising 30 okra (Abelmoschus esculentus) genotypes were grown and analysed for yield and its attributing traits at the Department of Vegetable science, Kumarganj, Faizabad during Zaid (2011) period. All the characters studied showed a wide range of variation. The variability for yield among the accessionsevaluated was also remarkable. The magnitude phenotypic coefficient of variation was higher than genotypic coefficient of variation for all traits. Both phenotypic coefficient of variation (PCV) and genotypic coefficient of variation (GCV) were high for plant height (11.10 and 10.60, respectively). Fruit weight exhibited low value of GCV (2.31) and PCV (4.74) and likely to show less response under selection. High heritability (91.3) with high genetic advance (26.74) was recorded for plant height, whereas, ridges per fruit had high heritability (97.0) with moderate genetic advance (18.45). This study aimed to evaluate okra genotypes for variability with a view to providing information on the development of high yielding genotypes to meet the growing food demand of the populace

FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE

The aim of the present study was to prepare bi-layer tablet of Metronidazole and Dicyclomine Hydrochloride for the effective treatment of Irritable Bowel Disease. Metronidazole and Dicyclomine Hydrochloride were formulated as immediate and sustained release layer respectively. The rational for formulation of bi-layer tablet of these two combinations was Metronidazole (immediate release) is strong antibiotic usually applied for antidiarrheal to treat inflammation of the large intestine and Dicyclomine Hydrochloride (Sustained release) is anticholinergic drug primarily used for irritable bowel disease. Bilayer tablet was suitable for maximizing the efficacy of drugs in irritable bowel disease

FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM OF TADALAFIL

This research work was aimed to enhance the oral bioavailability and provide faster onset of action of Tadalafil (used for the treatment of the erectile dysfunction (ED) and pulmonary arterial hypertension) by formulating its mouth dissolving film (MDF). Tadalafil belongs to BCS class II and the oral bioavailability of it’s about 28%. The MDF of Tadalafil was prepared by solvent casting method using HPMC-E5 (film forming agent), Methyl cellulose (thickening agent), Propylene glycol (plasticizer), Tween-80 (solubilizing agent), Microcrystalline cellulose (disintegrating agent), Citric acid (saliva stimulating agent), Sucrose (sweetening agent), Vanillin (flavoring agent), EDTA disodium (preservative). The formulation was optimized by two factors, three level (23) full factorial design using concentration of Plasticizer (X1) and concentration of film forming agent (X2) as independent variables and formulation was evaluated for uniformity of mass, thickness, folding endurance, drug content uniformity, in-vitro disintegration, in-vitro drug dissolution study and stability study. Based on results it was concluded that MDF (F5) showed enhanced bioavailability and faster onset of action as compared to available tablet dosage form

Cubosomes: A Novel Carrier for Transdermal Drug Delivery

Cubosomes are square and rounded particles with internal cubic lattice. Cubosomes are thermodynamically stable and consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomes are nanoparticles which are self assembled liquid crystalline particles of certain surfactants with proper ratio of water with microstructure that provides unique properties of practical interest. Bicontinuous cubic liquid crystalline phase is optically clear and very viscous material has the unique structure at nanometer scale. The word bicontinuous refers to the division of the two continuous but non-intersecting aqueous regions by lipid bilayer that is twisted into space filling structure. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. Self-assembled cubosomes as active drug delivery systems are receiving more and more attention and interest after the first discovery and nomination. They exhibit different internal cubic structure and composition with different drug-loading modalities. It has high internal surface area and cubic crystalline structures, relatively simple preparation method, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic and amphiphilic substances, targeting and controlled release of bioactive agents. Cubosomes are having wide range of applications in various fields and they can be characterized by various evaluation parameters. So, Cubosomes are gaining more attention in pharmaceutical field. Keywords: Cubosomes, Liquid crystal, drug-loading, hydrophilic, hydrophobic, amphiphilic

Study of tractive efficiency as an effect of ballast and tire inflation pressure in sandy loam soil

The experiments were conducted in sandy loam soil in stubble field.  Tillage operations were performed using   55 hp tractor with two bottom mouldboard plough and disc plough for four combinations of rear and front ballast (i.e. no ballast, 90 daN front, 90 daN front and 200 daN rear, 200 daN rear) and four combinations of inflation pressure in front and rear tires (i.e. 90 kPa rear and 140 kPa front, 90 kPa rear and 200 kPa front, 130 kPa rear and 140 kPa front and 130 kPa rear and 200 kPa front tire) to study their effects on tractive efficiency of tractor for primary tillage operations.  The test was conducted at recommended speed of operation 2.7 - 4 km h-1.  It was found from the results that combination of 200 daN rear ballast and inflation pressure of 130 kPa at rear, 200 kPa at front was found suitable for improving the performance of agricultural tractor with maximum tractive efficiency of 72.43% and 71.27% for mouldboard plough and disc plough respectively.   Keywords: tractor, ballast, inflation pressure, plough, tractive efficiency, sandy loam, primary tillag

Congestion Aware WSN-IoT-Application Layer Protocols for Healthcare Services

In the healthcare industry, WSN-IoT networks can be used to gather patient data for statistical purposes. IoT-based application-level protocols do not take into account these facts while forwarding the data to the gateway or server, which may degrade the network performance if the data was collected from a patient with ordinary/critical health issues and the route was busy or congested. In this paper, we'll look at the performance of two application layer protocols (i.e. CoAP and MQTT) within the constraints of a scalable network by integrating a congestion-aware scheme with them

Innovative Procurement Practices Increase Productivity

The farmer is an important part of the dairy industry, regardless of country. India is the largest milk-producing nation in the world, with 18% involvement of the dairy industry in the economy. Most of the world’s population depends on dairy industries for their livelihood, with about one-quarter involved in the production or purchase of milk and related products. It is essential for the Indian dairy industry to be able to fulfill growing customer demand with a satisfactory supply of milk. The procurement of milk and related products is very important in meeting this demand. Procurement is the act of gaining or obtaining goods and services. The process includes the preparation and processing of demand, along with final receipt and approval of payment. Procurement mainly depends on technology and innovations. The chapter mainly focuses on innovative practices for the procurement of milk in the Indian dairy industry. The four practices and recommendations given are very helpful in increasing the productivity of the dairy industry in India