No-Sense: Sense with Dormant Sensors

Wireless sensor networks (WSNs) have enabled continuous monitoring of an area of interest (body, room, region, etc.) while eliminating expensive wired infrastructure. Typically in such applications, wireless sensor nodes report the sensed values to a sink node, where the information is required for the end-user. WSNs also provide the flexibility to the end-user for choosing several parameters for the monitoring application. For example, placement of sensors, frequency of sensing and transmission of those sensed data. Over the years, the advancement in embedded technology has led to increased processing power and memory capacity of these battery powered devices. However, batteries can only supply limited energy, thus limiting the lifetime of the network. In order to prolong the lifetime of the deployment, various efforts have been made to improve the battery technologies and also reduce the energy consumption of the sensor node at various layers in the networking stack. Of all the operations in the network stack, wireless data transmission and reception have found to consume most of the energy. Hence many proposals found in the literature target reducing them through intelligent schemes like power control, reducing retransmissions, etc. In this article we propose a new framework called Virtual Sensing Framework (VSF), which aims to sufficiently satisfy application requirements while conserving energy at the sensor nodes.Comment: Accepted for publication in IEEE Twentieth National Conference on Communications (NCC-2014

EFFECT OF LEAD ON MALE REPRODUCTION IN EXPERIMENTAL ANIMAL MODEL

Introduction: In early 1960's, there is a first evidence of the toxic effects ionizing radiation on elevated oxygen levels in aerobes and proposed that oxygen toxicity is due to free radical formation. An alteration between oxidants and antioxidants in favour of the oxidants, potentially leading to damage is termed 'oxidative stress'. Lead and cadmium do not have any detectable beneficial biological roles rather it produces detrimental effects on biochemical, physiological and behavioral dysfunctions. Even a little lead poisoning can cause serious health problems, and at very high levels, it can be fatal. Mainly it affects the heamopoeitc system, Liver, Kidney, Cardiovascular system and reproductive system. Methodology: Experimental rats, injected intraperitoneally with lead acetate for 15 days at the dosage of 50, 100 mg/kg/day body weight and compared to control rats injected with deionized distilled water instead. At the end of study testis were removed and right testis was used for testicular antioxidant Malandealdehyde (MDA) levels estimation by Thiobarbituric acid reactive substance assay and left testis was used for histopathological analysis. Unpaired t test and ANOVA was used for statistical analysis. Results : The MDA (nmole /gm tissue) levels in control, lead 50mg, lead 100mg groups were 12.16±0.4, 17.06±0.16 and 18.11±0.13. Histopathology examination Lumen showing decreased sperm count and maturation. Some of the lumens showing absence sperm maturation. Conclusion: Study on lead-exposed rat testis have shown that reduction of spermatogenesis formation and sperm maturation. Increased MDA levels indicate that it may be due to oxidative stress. The toxicity of lead was noted at level ≥50mg/kg. Key words: Lead; Lipid peroxidation; Male reproduction; Testicular histology

EFFECT OF LEAD ON MALE REPRODUCTION IN EXPERIMENTAL ANIMAL MODEL

Introduction: In early 1960\u27s, there is a first evidence of the toxic effects ionizing radiation on elevated oxygen levels in aerobes and proposed that oxygen toxicity is due to free radical formation. An alteration between oxidants and antioxidants in favour of the oxidants, potentially leading to damage is termed \u27oxidative stress\u27. Lead and cadmium do not have any detectable beneficial biological roles rather it produces detrimental effects on biochemical, physiological and behavioral dysfunctions. Even a little lead poisoning can cause serious health problems, and at very high levels, it can be fatal. Mainly it affects the heamopoeitc system, Liver, Kidney, Cardiovascular system and reproductive system. Methodology: Experimental rats, injected intraperitoneally with lead acetate for 15 days at the dosage of 50, 100 mg/kg/day body weight and compared to control rats injected with deionized distilled water instead. At the end of study testis were removed and right testis was used for testicular antioxidant Malandealdehyde (MDA) levels estimation by Thiobarbituric acid reactive substance assay and left testis was used for histopathological analysis. Unpaired t test and ANOVA was used for statistical analysis. Results : The MDA (nmole /gm tissue) levels in control, lead 50mg, lead 100mg groups were 12.16±0.4, 17.06±0.16 and 18.11±0.13. Histopathology examination Lumen showing decreased sperm count and maturation. Some of the lumens showing absence sperm maturation. Conclusion: Study on lead-exposed rat testis have shown that reduction of spermatogenesis formation and sperm maturation. Increased MDA levels indicate that it may be due to oxidative stress. The toxicity of lead was noted at level ≥50mg/kg. Key words: Lead; Lipid peroxidation; Male reproduction; Testicular histology

Anticonvulsant effect of nifedipine, dizepam and in combination on pentylenetetrazol induced experimental models of epilepsy on albino rats

Background: In many patients, the presently available antiepileptic drugs such as phenobarbital, phenytoin, benzodiazepines, sodium valproate, etc., are unable to control seizures efficiently and the problem of adverse effects has also not been circumvented completely and approximately 30% of the patients continue to have seizures with current antiepileptic drugs therapy. Hence, search should continue to develop newer, more effective, and safer neuro-protective agents for treatment of epilepsy. Aim of the study was to investigate the activity of nifedipine, the dihydropyridine calcium channel blocker, diazepam, the benzodiazepine anti- convulsant of established efficacy and their combinations against rat models of pentylenetetrazol (PTZ) induced convulsions. Method: Wister albino rats of either sex, weighing between 150-220gm were used. Rats were divided into 10 groups, in each group n=6 total N=60.Methods: PTZ was administration 30 min after test drug administration. Intraperitoneal injection of PTZ at the dose of 80mg/Kg body weight were administered to the rats to produce chemically-induced seizure. The effect of nifedipine and diazepam were assessed on such seizure model. The onset and duration of clonic convulsion were recorded.Results: The onset time of PTZ-induced clonic convulsion was significantly prolonged with the Nifedipine in the doses of 4mg and 8mg per Kg. in comparison to nifedipine in dose of 2mg per Kg. The interesting observation was that while Diazepam in 1mg/Kg. dose significantly (P<0.05) prolonged the onset time, there was significant decrease (P <0.001) in the onset time of PTZ-induced clonic convulsion with diazepam in doses of 2 and 4mg per Kg. in comparison to Diazepam 1mg per Kg. But the combination of diazepam 2.5 mg and Nifedipine 2.6mg and 5.3mg exhibited significant prolongation of the onset time. Diazepam 1 and 2mg per Kg was found to be equally effective in reduction of convulsion time, while 4mg dose showed more reduction of convulsion time. The combination of diazepam and nifedipine showed no better reduction in the convulsion time and also valproic acid in doses of 135mg. Kg.Conclusions: Nifedipine (3-5mg/Kg) and diazepam (2.5mg/Kg.) combination delayed the onset of convulsion. Diazepam 2mg / Kg. alone was effective in reduction of duration of convulsion. The combination dose having 2.6mg of nifedipine showed comparable protection with valproic acid 135mg per Kg. while the combination having 5.3mg of nifedipine showed significantly better protection. 

Sialadenoma Papilliferum: Clinical Misdiagnosis with a Histological Decree

Sialadenoma papilliferum is a rare salivary gland tumor clinically resembling papilloma originating probably from the excretory duct. It is characterized by a biphasic growth pattern of exophytic squamous component and endophytic glandular component. We report a rare case of sialadenoma papilliferum in the floor of the mouth with epithelial dysplasia with pertinent review of literature. The present case highlights the importance of keeping sialadenoma papilliferum as a differential diagnosis of exophytic papilliferous oral lesions and the need to explore the etiology and malignant potential of the tumor

Enhancing school of cognition through Haptics

Learning through experience plays a very crucial role in spatial thinking, especially for children with poor progress in understanding concepts and with low memory skill. This study investigated whether the above mentioned problem can be overcome by a training program designed to enhance their cognition. Children with lower understanding of 2D and 3D objects and poor in mathematics were assessed on working memory and their academic performance before and after their adaptive training program. An adaptive training program was designed which enhances the learning experience of children by interacting with 3D objects using force feedback theory. The interaction itself creates a real experience of interacting with physical world and understand its parameters like weight, mass, force, friction, shape, material and viscosity. This finding indicates that the force feedback interaction with the 3D model creates a positive impact on working memory and associates with the cognitive development of children in the age of 8 to 10 years

EFFECT OF NICORANDIL ON PENTYLENETETRAZOLE (PTZ) INDUCED CONVULSIONS IN MICE

Aims &amp; Objectives: To evaluate or screen the anticonvulsant effect of Nicorandil a potassium channel opener in Pentylenetetrazole(PTZ) induced convusions in albino mice. Materials &amp; Methods: Mice of either sex weighing 20-25gms were selected for the present study. The animals were divided into 6 groups with each group consisting of 6 albino mice. Group 1 mice received placebo (0.2ml of distilled water) intraperitoneally (i.p), group 2 received sodium valproate 200 mg/kg/i.p. as positive control, while groups 3,4, 5 and 6 were administered Nicorandil 5, 10, 20 and 40 mg/kg i.p respectively. Pentylenetetrazole (PTZ) was administered in the dose of 100mg/kg i.p, 30mins after Nicorandil/ control drug pre-treatment. Onset and duration of clonic convulsion were recorded. Results: Nicorandil pretreatment in the dose of 5mg/kg increased onset time and significantly decreased the duration of convulsions,while the doses of 10, 20, 40mg/kg prevented the convulsions. Conclusion: Nicorandil possesses significant anticonvulsant activity comparable to sodium valproate on PTZ induced seizure in albino mice. KEYWORDS: Pentylenetetrazole; Sodium valproate; Nicorandil; Anticonvulsant activity

EFFECT OF NICORANDIL ON PENTYLENETETRAZOLE (PTZ) INDUCED CONVULSIONS IN MICE

Aims &amp; Objectives: To evaluate or screen the anticonvulsant effect of Nicorandil a potassium channel opener in Pentylenetetrazole(PTZ) induced convusions in albino mice. Materials &amp; Methods: Mice of either sex weighing 20-25gms were selected for the present study. The animals were divided into 6 groups with each group consisting of 6 albino mice. Group 1 mice received placebo (0.2ml of distilled water) intraperitoneally (i.p), group 2 received sodium valproate 200 mg/kg/i.p. as positive control, while groups 3,4, 5 and 6 were administered Nicorandil 5, 10, 20 and 40 mg/kg i.p respectively. Pentylenetetrazole (PTZ) was administered in the dose of 100mg/kg i.p, 30mins after Nicorandil/ control drug pre-treatment. Onset and duration of clonic convulsion were recorded. Results: Nicorandil pretreatment in the dose of 5mg/kg increased onset time and significantly decreased the duration of convulsions,while the doses of 10, 20, 40mg/kg prevented the convulsions. Conclusion: Nicorandil possesses significant anticonvulsant activity comparable to sodium valproate on PTZ induced seizure in albino mice. KEYWORDS: Pentylenetetrazole; Sodium valproate; Nicorandil; Anticonvulsant activity