Systemic Therapy in Endometrial Cancer: Recent Advances.

Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well. As more molecular pathways are being elucidated there is increasing role for targeted agents and future looks quite promising. We did an extensive search both online and offline for all the relevant articles including chemotherapy and targeted therapy for endometrial cancer

Geometric Morphology of Granular Materials

We present a new method to transform the spectral pixel information of a micrograph into an affine geometric description, which allows us to analyze the morphology of granular materials. We use spectral and pulse-coupled neural network based segmentation techniques to generate blobs, and a newly developed algorithm to extract dilated contours. A constrained Delaunay tesselation of the contour points results in a triangular mesh. This mesh is the basic ingredient of the Chodal Axis Transform, which provides a morphological decomposition of shapes. Such decomposition allows for grain separation and the efficient computation of the statistical features of granular materials.Comment: 6 pages, 9 figures. For more information visit http://www.nis.lanl.gov/~bschlei/labvis/index.htm

PARS: Programs for Analysis and Resizing of Structures, user manual

PARS processors and their use, flutter analysis, sensitivity analysis for stresses, and resizing are presented. Design variable definition and interface with finite element model, static constraints and their derivatives, flutter derivatives, and optimization are discussed

Itinerant and local-moment magnetism in EuCr2As2 single crystals

We report on the crystal structure, physical properties, and electronic structure calculations for the ternary pnictide compound EuCr2As2. X-ray diffraction studies confirmed that EuCr2As2 crystalizes in the ThCr2Si2-type tetragonal structure (space group I4/mmm). The Eu ions are in a stable divalent state in this compound. Eu moments in EuCr2As2 order magnetically below Tm = 21 K. A sharp increase in the magnetic susceptibility below Tm and the positive value of the paramagnetic Curie temperature obtained from the Curie-Weiss fit suggest dominant ferromagnetic interactions. The heat capacity exhibits a sharp {\lambda}-shape anomaly at Tm, confirming the bulk nature of the magnetic transition. The extracted magnetic entropy at the magnetic transition temperature is consistent with the theoretical value Rln(2S+1) for S = 7/2 of the Eu2+ ion. The temperature dependence of the electrical resistivity \r{ho}(T) shows metallic behavior along with an anomaly at 21 K. In addition, we observe a reasonably large negative magneto-resistance (~ -24%) at lower temperature. Electronic structure calculations for EuCr2As2 reveal a moderately high density of states of Cr-3d orbitals at the Fermi energy, indicating that the nonmagnetic state of Cr is unstable against magnetic order. Our density functional calculations for EuCr2As2 predict a G-type AFM order in the Cr sublattice. The electronic structure calculations suggest a weak interlayer coupling of the Eu moments.Comment: 9 pages, 7 figure

Valence Fluctuation in CeMo2Si2C

We report on the valence fluctuation of Ce in CeMo$_{2}$Si$_{2}$C as studied by means of magnetic susceptibility $\chi(T)$, specific heat $C(T)$, electrical resistivity $\rho(T)$ and x-ray absorption spectroscopy. Powder x-ray diffraction revealed that CeMo$_{2}$Si$_{2}$C crystallizes in CeCr$_{2}$Si$_{2}$C-type layered tetragonal crystal structure (space group \textit{P4/mmm}). The unit cell volume of CeMo$_{2}$Si$_{2}$C deviates from the expected lanthanide contraction, indicating non-trivalent state of Ce ions in this compound. The observed weak temperature dependence of the magnetic susceptibility and its low value indicate that Ce ions are in valence fluctuating state. The formal $L_{III}$ Ce valence in CeMo$_{2}$Si$_{2}$C $$ = 3.11 as determined from x-ray absorption spectroscopy measurement is well bellow the value $\simeq$ 3.4 in tetravalent Ce compound CeO$_{2}$. The temperature dependence of specific heat does not show any anomaly down to 1.8 K which rules out any magnetic ordering in the system. The Sommerfeld coefficient obtained from the specific heat data is $\gamma$ = 23.4 mJ/mol\,K$^{2}$. The electrical resistivity follows the $T{^2}$ behavior in the low temperature range below 35 K confirming a Fermi liquid behavior. Accordingly both the Kadowaki Wood ratio $A/\gamma^{2}$ and the Sommerfeld Wilson ratio $\chi(0)/\gamma$ are in the range expected for Fermi-liquid systems. In order to get some information on the electronic states, we calculated the band structure within the density functional theory, eventhough this approach is not able to treat 4f electrons accurately. The non-$f$ electron states crossing the Fermi level have mostly Mo 4d character. They provide the states with which the 4f sates are strongly hybridized, leading to the intermediate valent state.Comment: 18 pages, 10 figures Submitted to Journal of Alloys and Compound

Weakly commensurable arithmetic groups, lengths of closed geodesics and isospectral locally symmetric spaces

We introduce the notion of weak commensurabilty of arithmetic subgroups and relate it to the length equivalence and isospectrality of locally symmetric spaces. We prove many strong consequences of weak commensurabilty and derive from these many interesting results about isolength and isospectral locally symmetric spaces.Comment: 62 page

Influence of transverse-shear and large-deformation effects on the low-speed impact response of laminated composite plates

An analytical procedure is presented for determining the transient response of simply supported, rectangular laminated composite plates subjected to impact loads from airgun-propelled or dropped-weight impactors. A first-order shear-deformation theory is included in the analysis to represent properly any local short-wave-length transient bending response. The impact force is modeled as a locally distributed load with a cosine-cosine distribution. A double Fourier series expansion and the Timoshenko small-increment method are used to determine the contact force, out-of-plane deflections, and in-plane strains and stresses at any plate location due to an impact force at any plate location. The results of experimental and analytical studies are compared for quasi-isotropic laminates. The results indicate that using the appropriate local force distribution for the locally loaded area and including transverse-shear-deformation effects in the laminated plate response analysis are important. The applicability of the present analytical procedure based on small deformation theory is investigated by comparing analytical and experimental results for combinations of quasi-isotropic laminate thicknesses and impact energy levels. The results of this study indicate that large-deformation effects influence the response of both 24- and 32-ply laminated plates, and that a geometrically nonlinear analysis is required for predicting the response accurately

Raman spectra of GexAsySe1−x−y glasses

Various Ge–As–Se glasses spanning a mean coordination number (MCN) from 2.2 to 2.94 have been investigated using differential scanning calorimetry and Raman spectroscopy. The glass transition temperature Tg was found to increase with increasing MCN, except for those glasses located within the nanoscale phase-separated region of the phase diagram. The evolution of Raman features at wavenumbers from 150 to 350 cm⁻¹ exhibits two transitionlike features. Merging of the 225 and 250 cm⁻¹ modes at MCN=2.5 is a symbol of the extinction of Se–Se bonds. Additionally, the appearance of two modes at 280–290 and 170 cm⁻¹ at MCN>2.7 come from the defect modes of ethanelike Ge₂Se₆/₂. The increase in the scattering from these defects is an important factor leading to enhanced optical loss in the glasses with high MCN.This research was partly supported by the Australian Research Council through its Centres of Excellence and Federation Fellow Programs