Vitamin B 12: the hidden ingredient of stroke

Background: Study aimed to evaluate the relationship between vitamin B12 and acute cerebral stroke in this study.Methods: Blood samples drawn within 24 hours after the stroke from hospitalized patients (n=100) and from 100 control cases matched for age, sex and other modifiable risk factors of stroke were analyzed. With a competitive, ECLIA, serum levels of vitamin B12 were measured. The quantitative data of the groups was compared using Analysis of Varience and Tukeys HSD post hoc test for comparison. Chi-square tests were used.Results: Median serum vitamin B12 levels were significantly lower in the patients than in the control subjects, 188.71 and 256.25 pg/ml respectively (p=0.0001). This difference was independent from other risk factors. The mean age in case group was 62.49 (SD: 12.45 years) and 56.62 (SD: 13.05 years) in control group with p=0.001. Therefore, prevalence of stroke is more between 6th and 7th decade of life. Mean serum vitamin B12 levels were lower in males (201.8pg/ml) than the females (268.pg/ml) in the case group.Conclusions: Low vitamin B12 is associated with an increased risk of stroke, and its relationship is independent from the other known modifiable stroke risk factors

A Study on Awareness and Use of Personal Protective Equipment (PPE) Among Factory Workers Of GIDC Dared, Jamnagar city, Gujarat

Background: The proper use of safety measures by workers is an important way of preventing and/or reducing a variety of health hazards that they are exposed to during work. There is a lack of knowledge about hazards and personal protective equipment (PPE) and the use of PPE among the workers in industries of Dared GIDC is limited. Objectives: We designed a study to assess workers' awareness of hazards and PPE, and the use of PPE among the workers of industries of Dared GIDC and to find a possible correlation between awareness and use of PPE among them.Methodology: A cross-sectional study was conducted from September 2018 to November 2018.Total 640 subjects were selected by simple random sampling after conducting a pilot study, who provided data via the completion of a structured questionnaire. Results: As there are more chances of accidents in industrial set up, injuries due to accidents can be prevented by proper use of PPE during work. But the results indicate that only 45.16% workers knew about health hazards related to their occupation. Only 43.75% workers knew that these hazards could be prevented by use of PPE. Out of all only 38.6% workers were actually using PPE. Conclusion: The workers using PPE were those who were aware of hazards and PPE. There is a gap between being aware of hazards and use of PPE at work

A community based cross sectional study of prevalence and risk factors of low birth weight

Introduction: Birth weight is an independent and an important factor that affects mortality, morbidity and growth and development during infancy and later life. India is accounting for 40% of the global Burdon of low birth weight babies. Multiple causative factors identified to be responsible for low birth weight. Aims & objectives: 1. To estimate the prevalence of low birth weight babies. 2. To study the association of maternal factors with birth weight. Method:The present community based cross sectional study conducted to among the urban population of Rajkot city and identify the determinants of low birth weight. Sampling population was selected by multistage sampling method. Investigator collected history of low birth weight and other determinants by verification of records and examination by house to house visit. Result:The prevalence of low birth was found 19.6. The factors like sex of the baby, birth order, birth spacing, maternal age, maternal education, regular antenatal check-up and mother’s weight gain during pregnancy were found significant determinants of LBW. Conclusion:The prevalence of low birth was high in urban area require multipronged strategy. The primary health care can diminish the determinant of the low birth weight by adequate birth interval, two-child norms, regular antenatal check-up, supplementary nutrition to mother, female literacy etc

Home Automation System using ZigBee and PandaBoard as a Gateway (HAS-ZP)

Abstract — Today’s homes have as many wires as the number of devices to control. Home automation using ZigBee and PandaBoard as a gateway does away with the need for separate wires and even remotes. The wireless home area network doesn’t require line-ofsight communication. The HAS-ZP is a wireless home automation system that can be implemented in existing home environments, without any changes in the infrastructure. Home Automation lets the user control the home appliances from his or her smart-phone or laptop. The assigned actions can happen depending on time or other sensor readings such as light, temperature or sound from any connected device in the Home Automation network. With the help of PandaBoard, currently working as gateway, we can control, command, operate and observe the end devices. Here we are considering end devices like fan, bulb, TV, Music System, doors, windows etc. with the single gateway, the system can control entire home irrespective of number of rooms or boundaries where each room will be connected with single receiver

Sensory Analysis – A contemporary Quality Control tool for Asava-Arishta

Quality control of Ayurvedic medicines though being the need of the hour, is an arduous task. As Ayurveda encompasses the use of drug as a whole which leads to generation of a complex matrix. In such a scenario, selective and sensitive sophisticated analytical tools alone cannot serve the purpose. Besides, the ancient science of medicine is sensory driven. A number of sensory based quality standards in form of quality-attributes for drugs as well as critical end point for pharmaceutical operations are mentioned in the classics of Ayurveda. It is thus advisable to employ sensory based analytical methods for Quality control of Ayurvedic medicines. Henceforth, in the present study an attempt was made to develop a sensory based Quality control tool for discrimination of the market samples of Arjunaristha with regards to In-house prepared (Reference control) sample on the basis of smell and taste. Among the sensory methods available, Duo-Trio method was adopted. 40 pre-trained assessors were asked to identify the blindly coded sample analogous to Reference control. The results were analysed using Receiver Operating Characteristics (ROC) curve, Area Under Curve (AUC) and d-prime (d’) with the help of sensR package in R-studio ver. 1.0.143. In both the sample sets, Reference control sample was correctly identified with a significance level of P < 0.001 and Area Under Curve of 0.999 and 0.994 for each set respectively. Thus, it can be concluded that Sensory analysis method efficiently discriminated the Arjunaristha samples and thus can serve as a cost-effective routine quality control tool.&nbsp

A retrospective cohort study on prognostic factors and anti-thrombotic therapy and its correlation with disease outcome in patients of COVID-19

Abstract Background Since the outbreak of coronavirus disease 2019 (COVID-19), many studies have been conducted on clinical features, laboratory parameters, treatment, and anticoagulation therapy. However, there is a scarcity of studies investigating the relationship between prognostic parameters, anti-thrombotic agents, and their impact on disease outcomes within the regional population. A complete analysis of all the factors related to the prognostic, risk, therapies are important to identify the possible interpretation of the disease progression. To find out the utilization of antithrombotic therapy in patients of coronavirus disease 2019 and to study the correlation of antithrombotic therapy and prognostic factors with survival and non-survival. Methods In this retrospective study we included data of coronavirus disease 2019 positive patients who aged more than 18 with or without comorbidities, non-pregnant. We collected data of 768 patients from the medical record department of a tertiary care hospital. For the collected cohort data, we applied descriptive analysis and contingency analysis to find any difference between the surviving and non-surviving group of patients. Results We found that compared to survivors, the age was higher in non-surviving patients. Non-surviving patients had higher D-dimer, C-reactive protein (CRP), lactate dehydrogenase (LDH), and Ferritin levels than survival. The coagulation profile was changed in the non-surviving group. Further conducting contingency analysis, we found the critical role of anti-thrombotic agents in the outcome of the disease. We found that one anti-thrombotic agent has a varied result over another. Co-morbidities were found to be a significant factor for the outcome of the disease; as we analysed, we found diabetes mellitus and hypertension in most non-survivors. Conclusion We found that many prognostic factors were more important in finding the disease progression and can help in the administration of a particular anti-thrombotic therapy

Synthesis, characterization and antimalarial evaluation of new β-benzoylstyrene derivatives of acridine

A series of β-benzoylstyrene derivatives of acridine (4a–r) have been synthesized and characterized using IR, 1H NMR and Mass Spectroscopy. All the compounds were screened for intraerythrocytic in vitro antimalarial activity against Chloroquine-sensitive (3D7) & Chloroquine-resistant (Dd2) strains of Plasmodium falciparum using the SYBR Green I fluorescence assay. Cytotoxicity study was performed against the HeLa cell line using the MTT assay. Compounds 4c, 4d, and 4l are most potent with IC50 in the range of 0.30–0.52 μM against the 3D7 strain and 0.15–0.32 μM against the Dd2 strain. The results revealed that antimalarial potency and good resistance indices were not at the cost of safety since the most potent compounds have turned out to have promising therapeutic indices in the range of 80–520

NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer’s Disease

The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer’s disease (AD). The involvement of the NF-κB pathway in immune system responses, inflammation, oxidative stress, and neuronal survival highlights its significance in AD progression. We discuss the advantages of NF-κB pathway inhibition, including the potential to mitigate neuroinflammation, modulate amyloid beta (Aβ) production, and promote neuronal survival. However, we also acknowledge the limitations and challenges associated with this approach. Balancing the fine line between dampening inflammation and preserving physiological immune responses is critical to avoid unintended consequences. This review combines current knowledge on the NF-κB pathway’s intricate involvement in AD pathogenesis, emphasizing its potential as a therapeutic target. By evaluating both advantages and limitations, we provide a holistic view of the feasibility and challenges of NF-κB pathway modulation in AD treatment. As the quest for effective AD therapies continues, an in-depth understanding of the NF-κB pathway’s multifaceted roles will guide the development of targeted interventions with the potential to improve AD management