Hypericum sp.: essential oil composition and biological activities

Phytochemical composition of Hypericum genus has been investigated for many years. In the recent past, studies on the essential oils (EO) of this genus have been progressing and many of them have reported interesting biological activities. Variations in the EO composition of Hypericum species influenced by seasonal variation, geographic distribution, phenological cycle and type of the organ in which EO are produced and/or accumulated have also been reported. Although many reviews attributed to the characterization as well as biological activities of H. perforatum crude extracts have been published, no review has been published on the EO composition and biological activities of Hypericum species until recently (Crockett in Nat Prod Commun 5(9):1493–1506, 2010; Bertoli et al. in Global Sci Books 5:29–47, 2011). In this article, we summarize and update information regarding the composition and biological activities of Hypericum species EO. Based on experimental work carried out in our laboratory we also mention possible biotechnology approaches envisaging EO improvement of some species of the genus.Fundação para a Ciência e a Tecnologia (FCT) - project PTDC/AGR AAM/70418/2006, SFRH/BD/ 13283/2003

Balance and motor coordination are not fully developed in 7 years old blind children Coordenação motora e equilíbrio não são totalmente desenvolvidos em crianças cegas com 7 anos de idade

Visually impaired children show difficulties in recognizing their own bodies, objects around then and the spatial parameters that are essential for independent movement. This study analyzes the neuro-psychomotor development of a group of congenitally visually impaired children as compared to children with normal sight. We have evaluated two groups of seven-year-olds by means of neurological evolution examination (NEE). The group studied comprised 20 blind children and the control group comprised 20 children with normal sight, and they were paired up according to age and gender. In some tests, the blind children were guided by touch. The visually impaired children performed worse in tests evaluating balance and appendage coordination compared to normal sighted children (p< 0.001), and this suggests that visual deficiency impairs children's neuro-psychomotor development.<br>As crianças portadoras de deficiência visual possuem dificuldades em conhecer seu próprio corpo, objetos a sua volta e parâmetros espaciais imprescindíveis para locomoção independente. Este trabalho analisa o desenvolvimento neuropsicomotor de um grupo de crianças com deficiência visual congênita em comparação a crianças com visão normal. Avaliamos dois grupos de crianças de sete anos de idade, através do exame neurológico evolutivo (ENE). O grupo estudado era constituído de 20 crianças cegas e o grupo controle constituído de 20 crianças com visão normal, pareadas por idade e sexo. Em algumas provas, as crianças cegas foram instruídas pelo tato. As crianças portadoras de deficiência visual tiveram pior desempenho nas provas que avaliaram o equilíbrio e coordenação apendicular, quando comparadas às crianças com visão normal (p< 0,001), sugerindo que o déficit visual compromete o desenvolvimento neuropsicomotor da criança