Inondations dans le Gard : bilan

Le 9 septembre 2002, le canal de la Fontaine à Nîmes débordait, inondant les quatre étages de la bibliothèque-Carré-d’Art : questions à Benoît Lecoq, directeur

Status of ALS Treatment, Insights into Therapeutic Challenges and Dilemmas

Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor neurons that eventually leads to death. Despite impressive advances in understanding the genetic, molecular, and pathological mechanisms of the disease, the only drug approved to date by both the FDA and EMA is riluzole, with a modest effect on survival. In this opinion view paper, we will discuss how to address some challenges for drug development in ALS at the conceptual, technological, and methodological levels. In addition, socioeconomic and ethical issues related to the legitimate need of patients to benefit quickly from new treatments will also be addressed. In conclusion, this brief review takes a more optimistic view, given the recent approval of two new drugs in some countries and the development of targeted gene therapies

Bernard Mnich : carnet de route en Slovénie

Un choix rare et personnel. Bernard Mnich, bibliothécaire à Neuilly-sur-Seine a effectué, en 2001, un stage de trois semaines à la médiathèque de l’Institut français Charles-Nodier à Ljubljana dans le cadre de sa formation post-titularisation. Découverte d’une culture slave, installée sur l’autre rive de la Méditerranée, et d’un équipement dédié à la France

Interview de Pierre-Gilles Flacsu

Librairie Chroniques & Chantelivre, Issy-les-Moulineau

Behavioral and affective disorders after brain injury: French guidelines for prevention and community supports

AbstractObjectiveThe purpose of this study was to elaborate practice guidelines for the prevention of behavioral and affective disorders in adult outpatients after traumatic brain injury (TBI); but also to identify the support systems available for family, caregivers of patients with TBI within the community.MethodsThe elaboration of these guidelines followed the procedure validated by the French health authority for good practice recommendations, close to the Prisma statement. This involved a systematic and critical review of the literature looking for studies that investigated the impact of programs in community settings directed to behavioral and affective disorders post-TBI. Recommendations were than elaborated by a group of professionals and family representatives.ResultsOnly six articles were found comprising 4 studies with a control group. Two studies showed a beneficial effect of personalized behavior management program delivered within natural community settings for persons with brain injury and their caregivers. Two other studies showed the relevance of scheduled telephone interventions to improve depressive symptoms and one study emphasized the usefulness of physical training. One study investigated the relevance of an outreach program; this study showed an improvement of the patients’ independence but did not yield any conclusions regarding anxiety and depression.Discussion and recommendationsIn addition to the application of care pathways already established by the SOFMER, prevention of behavioral and affective disorders for brain-injured outpatients should involve pain management, as well as development of therapeutic partnerships. It is recommended to inform patients, their family and caregivers regarding the local organization and facilities involved in the management of traumatic brain injury. The relevance of therapeutic education for implementing coping strategies, educating caregivers on behavioral disorder management, follow-up telephone interventions, and holistic therapy seems established. The level of evidence is low and preliminary studies should be confirmed with larger controlled trials

Découvertes de résidus de préparations alimentaires dans quatre sites gaulois du Centre

La découverte de quatre caramels alimentaires en région Centre sur des sites de La Tène a incité à caractériser plus précisément les résidus de préparations alimentaires détectés parmi les vestiges archéologiques. Divers procédés de préparatifs culinaires ont été répertoriés pour lesquels sont détaillés les différentes formes sous lesquels un aliment végétal sec peut être utilisé ainsi que le type de préparation obtenue. Grâce à une observation minutieuse des résidus archéologiques et en se référant aux critères précédemment établis, des hypothèses sont émises sur les types de préparations qui ont été élaborés à l’âge du Fer.The detection of four caramels in the context of La Tene sites in the Center of France has led to further investigations in view to specify food residues identified among the archaeological finds. Various methods of culinary preparation have been listed. Different use of dry plant aliment and the type of preparation obtained are detailed. Through careful observation of archaeological residues and by reference to previously established criteria, assumptions are made about the types of preparations that have been developed during the Iron Age